The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Leukocyte adherence to venular endothelium during ischemia-reperfusion
Abstract
Xanthine oxidase-derived oxidants and leukocytes have been implicated in the microvascular injury associated with reperfusion of ischemic intestine. The objective of this study was to determine whether xanthine oxidase-derived oxidants play a role in the leukocyte-microvascular interactions initiated by ischemia-reperfusion. Adherence and extravasation of leukocytes were monitored in cat mesenteric venules subjected to 1 h of ischemia (blood flow reduced to 20% of control) and reperfusion. Leukocyte rolling velocity, vessel diameter, and red cell velocity were also measured in control (untreated) animals and in animals pretreated with either allopurinol or superoxide dismutase. The responses of venular blood flow, wall shear rate, and leukocyte rolling velocity to ischemia and reperfusion did not differ between the three experimental groups. In control animals, 1 h of ischemia was associated with significant adherence and extravasation of leukocytes with reperfusion greatly enhancing these responses. Allopurinol treatment did not alter the responses to ischemia per se, yet it largely prevented the further increment in adherence and extravasation associated with reperfusion. Superoxide dismutase treatment attenuated the leukocyte responses elicited by both ischemia and reperfusion. Our observations that both allopurinol and superoxide dismutase attenuate reperfusion-induced leukocyte adherence and extravasation are consistent with the hypothesis that xanthine oxidase-derived oxidants initiate the leukocyte infiltration induced by reperfusion of ischemic intestine.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Superoxide radicals in feline intestinal ischemia
Granger, D. N., Rutili, G., & McCord, J. M. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90648-x · Cited by 1,198
Self-citationXanthine oxidase and neutrophil infiltration in intestinal ischemia
Grisham, M. B., Hernandez, L. A., & Granger, D. N. (1986) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1986.251.4.g567 · Cited by 720
Self-citationRole of neutrophils in ischemia-reperfusion-induced microvascular injury
Hernandez, L. A., Grisham, M. B., Twohig, B., Arfors, K. E., Harlan, J. M., & Granger, D. N. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.253.3.h699 · Cited by 698
Self-citationIschemia-reperfusion injury: role of oxygen-derived free radicals.
Granger, D. N., Höllwarth, M. E., & Parks, D. A. (1986) · PubMed · Cited by 676
Self-citationSimpson, P. J., Todd, R. F., Fantone, J. C., Mickelson, J. K., Griffin, J. D., & Lucchesi, B. R. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113364 · Cited by 636
Vedder, N. B., Winn, R. K., Rice, C. L., Chi, E. Y., Arfors, K. E., & Harlan, J. M. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113407 · Cited by 425
Leukocyte-endothelium adhesion: Microhemodynamics in mesentery of the cat
House, S. D., & Lipowsky, H. H. (1987) · Microvascular Research · doi:10.1016/0026-2862(87)90068-9 · Cited by 334
Ischemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals
Parks, D. A., & Granger, D. N. (1983) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1983.245.2.g285 · Cited by 320
Self-citationRole of xanthine oxidase and granulocytes in ischemia-reperfusion injury
Granger, D. N. (1989) · Journal of Critical Care · doi:10.1016/0883-9441(89)90011-7 · Cited by 88
Self-citationAllopurinol does not enhance antioxidant properties of extracellular fluid
Zimmerman, B. J., Parks, D. A., Grisham, M. B., & Granger, D. N. (1988) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1988.255.1.h202 · Cited by 68
Self-citation
Cited by
The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion
Granger, D. N., & Kubes, P. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.5.662 · Cited by 849
Self-citationHuot, J., Houle, F., Marceau, F., & Landry, J. (1997) · Circulation Research · doi:10.1161/01.res.80.3.383 · Cited by 567
Nitric oxide modulates microvascular permeability
Kubes, P., & Granger, D. N. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.262.2.h611 · Cited by 565
Self-citationpanés, J., & Granger, D. N. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70328-2 · Cited by 370
Self-citationUric acid in chronic heart failure: a marker of chronic inflammation
Leyva, F. (1998) · European Heart Journal · doi:10.1053/euhj.1998.1188 · Cited by 287
Metadata
- Authors
- Granger, D. N., Benoit, J. N., Suzuki, M., & Grisham, M. B.
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 1989-11-01
- Volume
- 257
- Issue
- 5
- Pages
- G683-G688
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2184012549
- Cited by
- 373
- References
- 11
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Leukocyte adherence to venular endothelium during ischemia-reperfusion. https://app.cochat.ai/papers/10.1152/ajpgi.1989.257.5.g683
- The paper
- Granger, D. N., Benoit, J. N., Suzuki, M., & Grisham, M. B. (1989). Leukocyte adherence to venular endothelium during ischemia-reperfusion. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.1989.257.5.g683
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
