The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Vagal afferent responses to fatty acids of different chain length in the rat
Abstract
The role of cholecystokinin (CCK) in the effect of dietary lipid on proximal gastrointestinal function and satiety is controversial. Recent work suggests that fatty acid chain length may be a determining factor. We investigated the mechanism by which long- and short-chain fatty acids activate jejunal afferent nerves in rats. Whole mesenteric afferent nerve discharge was recorded in anaesthetized male Wistar rats during luminal perfusion of saline, sodium oleate, and sodium butyrate (both 10 mM). Both fatty acids evoked characteristic afferent nerve responses, distinct from the mechanical response to saline, that were abolished in rats following chronic subdiaphragmatic vagotomy. The effect of oleate was abolished by the CCK-A receptor antagonist Devazepide (0.5 mg/kg), whereas the effect of butyrate persisted despite pretreatment with either Devazepide or a combination of the calcium channel inhibitors nifedipine (1 mg/kg) and the omega-conotoxins GVIA and SVIB (each 25 microg/kg). In summary, long- and short-chain fatty acids activate intestinal vagal afferents by different mechanisms; oleate acts via a CCK-mediated mechanism and butyrate appears to have a direct effect on afferent terminals.
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“SCFAs also activate vagal afferents in the gastrointestinal tract (364), transducing electric signals to modulate neurotransmitter levels in the brain and brain function.”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [364]
In the citing paper
“Vagal afferents express receptors that sense SCFAs55, and activation of this pathway has been implicated in glucose homeostasis56.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [55]
Citations
Cites
Bioassay of plasma cholecystokinin in rats: Effects of food, trypsin inhibitor, and alcohol
Liddle, R. A., Goldfine, I. D., & Williams, J. A. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90524-9 · Cited by 410
Noble, F., Wank, S. A., Crawley, J. N., Bradwejn, J., Seroogy, K. B., Hamon, M., & Roques, B. P. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01427-3 · Cited by 385
A relation between the chain length of fatty acids and the slowing of gastric emptying
Hunt, J. N., & Knox, M. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008411 · Cited by 301
Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility
McLaughlin, J. T., Lucà, M. G., Jones, M. N., D’Amato, M., Dockray, G. J., & Thompson, D. G. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70227-1 · Cited by 262
Self-citationEffects of cholecystokinin (CCK-8) on two classes of gastroduodenal vagal afferent fibre
Blackshaw, L. A., & Grundy, D. (1990) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(90)90185-l · Cited by 221
Self-citationBerthoud, H., Kressel, M., Raybould, H., & Neuhuber, W. (1995) · Anatomy and Embryology · doi:10.1007/bf00187819 · Cited by 216
Bertrand, P. P., Kunze, W., Bornstein, J. C., Furness, J. B., & Smith, M. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.2.g422 · Cited by 208
Cholecystokinin and Pancreozymin, one single Hormone?
Jorpes, E., & Mutt, V. (1966) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1966.tb03185.x · Cited by 196
Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1
Hadjiagapiou, C., Schmidt, L. N., Dudeja, P. K., Layden, T. J., & Ramaswamy, K. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.4.g775 · Cited by 182
I. CCK receptors: an exemplary family
Wank, S. A. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.4.g607 · Cited by 180
Feinle, C., D’Amato, M., & Read, N. W. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8613041 · Cited by 164
Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients
Yox, D. P., & Ritter, R. C. (1988) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1988.255.4.r569 · Cited by 160
Hillsley, K., Kirkup, A. J., & Grundy, D. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.551bw.x · Cited by 150
Self-citationMcLaughlin, J. T., Lomax, R. B., Hall, L., Dockray, G. J., Thompson, D. G., & Warhurst, G. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.011by.x · Cited by 142
Self-citationMoriarty, P., Dimaline, R., Thompson, D. G., & Dockray, G. J. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00675-6 · Cited by 131
Self-citationHolzer, H. H., Turkelson, C. M., Solomon, T. E., & Raybould, H. E. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.267.4.g625 · Cited by 127
Berthoud, H. R., & Patterson, L. M. (1996) · Cells Tissues Organs · doi:10.1159/000147837 · Cited by 125
Role of Cholecystokinin in the Regulation of Gastrointestinal Motility
Grider, J. R. (1994) · Journal of Nutrition · doi:10.1093/jn/124.suppl_8.1334s · Cited by 121
Richards, W., Hillsley, K., Eastwood, C., & Grundy, D. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021781 · Cited by 117
Self-citationVagal receptors sensitive to lipids in the small intestine of the cat
Melone, J. (1986) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(86)90060-3 · Cited by 106
Satiety effects of cholecystokinin in humans
Lieverse, R. J., Jansen, J. B. �. �., Masclee, A., & Lamers, C. B. H. W. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90397-2 · Cited by 98
I. Sensing of lipid by the intestinal mucosa
Raybould, H. E. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.4.g751 · Cited by 97
Randich, A., Tyler, W. J., Cox, J. E., Meller, S. T., Kelm, G. R., & Bharaj, S. S. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.1.r34 · Cited by 89
Inhibition of gastric emptying in response to intestinal lipid is dependent on chylomicron formation
Raybould, H. E., Meyer, J. H., Tabrizi, Y., Liddle, R. A., & Tso, P. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.6.r1834 · Cited by 89
Expression of cholecystokinin a receptors in neurons innervating the rat stomach and intestine
Sternini, C., Wong, H. C., Pham, T., GIORGIO, R. D., Miller, L. J., Kuntz, S. M., Reeve, J. R., Walsh, J. H., & Raybould, H. E. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70399-9 · Cited by 85
Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat
Kirkup, A. J., Booth, C. E., Chessell, I. P., Humphrey, P. P. A., & Grundy, D. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00551.x · Cited by 84
Self-citationSuppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation
Walls, E. K., Phillips, R. J., Wang, F., Holst, M., & Powley, T. L. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.269.6.r1410 · Cited by 84
Vagotomy attenuates suppression of sham feeding induced by intestinal nutrients
Yox, D. P., Stokesberry, H., & Ritter, R. C. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.3.r503 · Cited by 79
Wessler, I. K., Dooley, D. J., Werhand, J., & Schlemmer, F. (1990) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00180653 · Cited by 75
Guimbaud, R., Moreau, J., Bouisson, M., Durand, S., Escourrou, J. R., Vaysse, N., & Frexinos, J. (1997) · Pancreas · doi:10.1097/00006676-199701000-00012 · Cited by 73
Role of cholecystokinin as a regulator of solid and liquid gastric emptying in humans
Borovicka, J., Kreiss, C. M., Asal, K., Remy, B., Mettraux, C., Wells, A. S., Read, N. W., Jansen, J. B. �. �., D'Amato, M., Delaloye, A. B., et al. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.271.3.g448 · Cited by 56
Li, Y., & Owyang, C. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118568 · Cited by 54
Grider, J. R., & Makhlouf, G. M. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90855-9 · Cited by 54
Lloyd, K. C. K., Holzer, H. H., Zittel, T. T., & Raybould, H. E. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.264.4.g659 · Cited by 48
Lomax, R. B., Gallego, S., Novalbos, J., Garcı́a, A. G., & Warhurst, G. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70286-6 · Cited by 41
Somatostatin is released in response to cholecystokinin by activation of type A CCK receptors
Lloyd, K. C. K., Maxwell, V., Chuang, C. N., Wong, H. C., Soll, A. H., & Walsh, J. H. (1994) · Peptides · doi:10.1016/0196-9781(94)90006-x · Cited by 36
Zeng, N., Athmann, C., Kang, T., Walsh, J. H., & Sachs, G. M. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.6.g1268 · Cited by 30
Effect of cholecystokinin-A receptor blockade on lipid-induced gastric relaxation in humans
Mesquita, M. A., Thompson, D. G., Troncon, L. E. D. A., D’Amato, M., Rovati, L. C., & Barlow, J. D. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.1.g118 · Cited by 30
Self-citationBoden, P., Hall, M. D., & Hughes, J. M. (1995) · Cellular and Molecular Neurobiology · doi:10.1007/bf02071316 · Cited by 30
Intestinal effects of the products of lipid digestion on gastric electrical activity in the cat
Melone, J., & Mei, N. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90206-z · Cited by 26
Effects of calcium channel blockade on intestinal fluid secretion: sites of action
Peregrin, A. T., Ahlman, H. K., Jodal, M., & Lundgren, O. (1997) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1997.00173.x · Cited by 21
Cunningham, S. M. C., Mihara, S., & Higashi, H. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.425bn.x · Cited by 16
Acetate absorption in the normal and secreting rat jejunum.
Watson, A. J. M., Elliott, E. J., Rolston, D. D. K., Borodo, M. M., Farthing, M. J. G., & Fairclough, P. D. (1990) · Gut · doi:10.1136/gut.31.2.170 · Cited by 13
Maggi, C. A., Grimaldi, G., & Meli, A. (1983) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.33.335 · Cited by 11
Characterization of CCK A Receptor Mediated Pepsinogen Secretion in Porcine Chief Cells
Meyer, G., Beinborn, M., & Sewing, K. (2008) · Pharmacology · doi:10.1159/000139414 · Cited by 5
Ciliax (1999) · doi:10.1002/(sici)1096-9861(19990621)409:1
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Metadata
- Authors
- Lal, S., Kirkup, A. J., Brunsden, A. M., Thompson, D. G., & Grundy, D.
- Affiliations
- Salford Royal Hospital (GB)
- University of Sheffield (GB)
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2001-10-01
- Volume
- 281
- Issue
- 4
- Pages
- G907-G915
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2256831100
- Cited by
- 303
- References
- 46
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 22 · 2023: 29 · 2022: 24 · 2021: 23 · 2020: 20 · 2019: 13 · 2018: 18 · 2017: 4 · 2016: 8 · 2014: 13 · 2013: 7 · 2012: 8
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- fatty acid chain length, vagal afferent nerves, cholecystokinin, sodium oleate, sodium butyrate, CCK-A receptor, devazepide, omega-conotoxin, nifedipine, subdiaphragmatic vagotomy, dietary fat
- MeSH terms
- Animals, Cholecystokinin, Electrophysiology, Hormone Antagonists, Jejunum, Male, Mesentery, Neurons, Afferent, Vagotomy, Vagus Nerve, Rats, Wistar, Oleic Acid, Devazepide, Butyric Acid, Rats
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