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Characterization of mechanosensitive splanchnic nerve afferent fibers innervating the rat stomach
Abstract
Splanchnic nerve fibers innervating the stomach were studied in anesthetized rats; 997 fibers in the T(9) or T(10) dorsal roots were identified by electrical stimulation of the splanchnic nerve. Thirty-one fibers responded to gastric distension. Extrapolated response thresholds ranged between 0 and 53 mmHg; seven fibers had thresholds for response > or =30 mmHg. Thermo- and/or chemosensitivity was tested in 18 of the 31 fibers. Four of twelve fibers responded to intragastric perfusion of heated saline; none of eight fibers tested responded to perfusion of cold saline. Infusion of glucose, L-arginine, or potassium oleate produced no change in resting activity. Intragastric instillation of 12% glycerol or an inflammatory soup (bradykinin 10(-5) M, PGE(2) 10(-5) M, serotonin 10(-5) M, histamine 10(-5) M, and KCl 10(-3) M) and prior heat stimulation sensitized responses to distension. The results reveal the presence of low- and high-threshold mechanosensitive fibers in the splanchnic innervation of the stomach. These fibers have the ability to sensitize, and they likely contribute to pain and altered sensations that can arise from the stomach.
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“Different forces (distension, contraction, stroking) applied to the stomach wall activate both the vagal 167-169 and the spinal splanchnic 170,171 nerves,”
From Interoceptive rhythms in the brain (2023) · cites this paper as [171]
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Cited by
Sorted by citations
Gastric distention activates satiety circuitry in the human brain
Wang, G.-J., Tomasi, D., Backus, W., Wang, R., Telang, F., Geliebter, A., Korner, J., Bauman, A., Fowler, J. S., Thanos, P. K., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.11.008 · Cited by 297
Interoceptive rhythms in the brain
Engelen, T., Solcà, M., & Tallon-Baudry, C. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01425-1 · Cited by 207
“Beyond diet and body-related aspects, given the extent of the gastric network, the gastric rhythm has been proposed to orchestrate brain dynamics between the different modules of the external senses and action, bypassing higher-level regions 181 , but this hypothesis has not been experimentally…”
Perez‐Burgos, A., Wang, L., McVey Neufeld, K., Mao, Y., Ahmadzai, M., Janssen, L. J., Stanisz, A. M., Bienenstock, J., & Kunze, W. A. (2015) · The Journal of Physiology · doi:10.1113/jp270229 · Cited by 123
Metadata
- Authors
- Ozaki, N., & Gebhart, G. F.
- Affiliations
- University of Iowa (US)
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2001-12-01
- Volume
- 281
- Issue
- 6
- Pages
- G1449-G1459
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2095912364
- Cited by
- 100
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 3 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 3 · 2013: 6 · 2012: 5
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (DNS-35790, NS 19912, R01NS019912)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- splanchnic nerve, mechanosensitive neurons, gastric distension, visceral pain, thermal sensitivity, chemosensitivity, inflammatory soup, bradykinin, prostaglandin E2, serotonin, histamine, potassium oleate, sensory sensitization, visceral innervation
- MeSH terms
- Afferent Pathways, Animals, Biomechanical Phenomena, Chemoreceptor Cells, Electric Stimulation, Hot Temperature, Male, Mechanoreceptors, Nerve Fibers, Splanchnic Nerves, Stomach, Reproducibility of Results, Rats, Sprague-Dawley, Rats
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