Proteogenomics reveals sex-biased aging genes and coordinated splicing in cardiac aging
Open accessPublished version of a preprint
Abstract
Han et al. used proteogenomics to compare male and female mouse hearts at 4 and 20 mo. Sex-biased cardiac genes function in mitochondrial metabolism, translation, autophagy, and other processes. Hundreds of cardiac genes show sex-by-age interactions, that is, sex-biased aging genes. Cardiac aging is accompanied with a remodeling of exon usage in functionally coordinated genes, concomitant with differential expression of RNA-binding proteins and splice factors. These features represent an underinvestigated aspect of cardiac aging that may be relevant to the search for disease mechanisms.
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References 104 · Cited by 31
- Authors
- Han, Y., Wennersten, S. A., Wright, J. M., Ludwig, R. W., Lau, E., & Lam, M. P. Y.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Lam, Maggie P. Y.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2022-09-01
- Volume
- 323
- Issue
- 3
- Pages
- H538-H558
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC9448281
- OpenAlex
- W4289947631
- Cited by
- 31
- References
- 104
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 11 · 2023: 10 · 2022: 1
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Colorado
- University of Colorado School of Medicine, Anschutz Medical Campus
- HHS | NIH | NIH Office of the Director (R03OD032666)
- HHS | NIH | National Heart, Lung, and Blood Institute (R00HL127302, R01HL141278, R21HL150456, F32HL149191, R00HL144829)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Keywords
- cardiac aging, sex differences, exon usage, RNA-binding proteins, proteogenomics, mitochondrial metabolism, autophagy, translation (biology), cardiac remodeling
- MeSH terms
- Proteogenomics, Aging, Animals, Female, Male, RNA Splicing, RNA-Binding Proteins, Alternative Splicing, Mice
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