Ischemic preconditioning alters real-time measure of O2 radicals in intact hearts with ischemia and reperfusion

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

Murry, C. E., Jennings, R. B., & Reimer, K. A. (1986) · Circulation · doi:10.1161/01.cir.74.5.1124 · Cited by 7,813

Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress

LeBel, C. P., Ischiropoulos, H., & Bondy, S. C. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00026a012 · Cited by 2,694

Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes

Vanden Hoek, T. L., Becker, L. B., Shao, Z., Li, C., & Schumacker, P. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18092 · Cited by 721

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

Bolli, R., Patel, B. S., Jeroudi, M. O., Lai, E. K., & McCay, P. B. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113621 · Cited by 685

Opening of Mitochondrial K ATP Channels Triggers the Preconditioned State by Generating Free Radicals

Pain, T., Yang, X.-M., Critz, S. D., Yue, Y., Nakano, A., Liu, G. S., Heusch, G., Cohen, M. V., & Downey, J. M. (2000) · Circulation Research · doi:10.1161/01.res.87.6.460 · Cited by 662

Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical

Benov, L., Sztejnberg, L., & Fridovich, I. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00163-4 · Cited by 495

Oxygen Radicals Released During Ischemic Preconditioning Contribute to Cardioprotection in the Rabbit Myocardium

Baines, C. P., Goto, M., & Downey, J. M. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0265 · Cited by 484 · cited 6×

Mitochondrial PKCε and MAPK Form Signaling Modules in the Murine Heart

Baines, C. P., Zhang, J., Wang, G.-W., Zheng, Y.-T., Xiu, J. X., Cardwell, E. M., Bolli, R., & Ping, P. (2002) · Circulation Research · doi:10.1161/01.res.0000012702.90501.8d · Cited by 429

Generation of superoxide in cardiomyocytes during ischemia before reperfusion

Becker, L. B., Hoek, T. L. V., Shao, Z., Li, C., & Schumacker, P. T. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.6.h2240 · Cited by 413

Significant Levels of Oxidants are Generated by Isolated Cardiomyocytes During Ischemia Prior to Reperfusion

Hoek, T. L. V., Li, C., Shao, Z., Schumacker, P. T., & Becker, L. B. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1997.0497 · Cited by 398

Reactive Oxygen Species and Cardiac Preconditioning: Many Questions Remain

Stowe, D. F., & Riess, M. L. (2004) · Cardiovascular Drugs and Therapy · doi:10.1023/b:card.0000029082.45753.49 · Cited by 9

Hypothermia Prevents Cardiac Dysfunction during Acute Ischemia Reperfusion by Maintaining Mitochondrial Bioenergetics and by Promoting Hexokinase II Binding to Mitochondria

Sun, J., Mishra, J., Yang, M., Stowe, D. F., Heisner, J. S., An, J., Kwok, W., & Camara, A. K. S. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4476448 · Cited by 9

Immediate Early Response Gene X‐1 (IEX‐1) Mediates Ischemic Preconditioning‐Induced Cardioprotection in Rats

Xu, M., Cai, Y., Qu, A., Shyy, J. Y.-J., Li, W., & Wang, X. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6109061 · Cited by 9

Redox Aspects of Myocardial Ischemia/Reperfusion Injury and Cardioprotection

Pagliaro, P., Femminò, S., & Penna, C. R. R. (2019) · Springer eBooks · doi:10.1007/978-981-13-8273-4_13 · Cited by 9

Protective effects of amlodipine on mitochondrial injury in ischemic reperfused rat heart.

Khan, N. A., Chattopadhyay, P., Abid, M., Pawdey, A., Kishore, K., & Wahi, A. K. (2012) · PubMed · Cited by 9

Peroxynitrite decreases arrhythmias induced by ischaemia reperfusion in anaesthetized dogs, without involving mitochondrial KATP channels

Kiss, A., Juhász, L., Huliák, I., & Végh, Á. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.344 · Cited by 9

Optical mapping of myocardial reactive oxygen species production throughout the reperfusion of global ischemia

Lu, L., Liu, Y., Sun, C., Lin, L., Su, M., & Wu, C. (2006) · Journal of Biomedical Optics · doi:10.1117/1.2186321 · Cited by 9

Adding ROS Quenchers to Cold K + Cardioplegia Reduces Superoxide Emission During 2-Hour Global Cold Cardiac Ischemia

Aldakkak, M., Stowe, D. F., Heisner, J. S., Riess, M. L., & Camara, A. K. S. (2011) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248410389815 · Cited by 9

Cardiac ischaemia/reperfusion in pigs and mice increases cardiomyocyte Krüppel-like factor 5 that aggravates tissue injury and remodelling

Mylonas, N., Siokatas, G., Zacharia, E. M., Pol, C. J., Rolland, T. J., Kyriazis, I. D., Hoffman, M., Hildebrand, A. N., Bannister, T. D., Gao, E., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf040 · Cited by 8

Cardioprotective Effect of ‘Methylamine Irisolidone’, a New Compound, in Hypoxia/Reoxygenation Injury in Cultured Rat Cardiac Myocytes

Mu, Y., Yan-ying, X., Zhou, L., Zhong, Y., Liu, L., Bai, H., Wang, Y., & Zhang, X. (2009) · Chemistry & Biodiversity · doi:10.1002/cbdv.200800314 · Cited by 8

Δ9-Tetrahydrocannabinol (Δ9-THC) Improves Ischemia/Reperfusion Heart Dysfunction and Might Serve as a Cardioprotective Agent in the Future Treatment

Banaszkiewicz, M., Tarwacka, P., Krzywonos‐Zawadzka, A., Olejnik, A., Laprairie, R. B., Noszczyk-Nowak, A., Sawicki, G., & Bil‐Lula, I. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2704114 · Cited by 7

Postconditioning and Remote Postconditioning of Ischemic Rat Cardiac Grafts

Tang, Y., Mennander, A., Oksala, N., Atalay, M., Syvälä, H., Lagerstedt, A., Kuuslahti, M., Nieminen, R., Anas, N., Moilanen, E., et al. (2010) · European Surgical Research · doi:10.1159/000315479 · Cited by 7

Therapy Against Ischemic Injury

Guarini, G., Huqi, A., Capozza, P., Morrone, D., Donati, F., & Marzilli, M. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319250008 · Cited by 6

Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model

Yang, M., Dong, J., Li, L., Che, H., Yong, J., Song, F., Wang, T., & Zhang, J.-W. (2015) · Gastroenterology Research and Practice · doi:10.1155/2016/2604032 · Cited by 6

Genetically determined mitochondrial preservation and cardioprotection against myocardial ischemia-reperfusion injury in a consomic rat model

Nabbi, R., Gadicherla, A. K., Kersten, J. R., Stowe, D. F., Lazar, J., & Riess, M. L. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00118.2013 · Cited by 6

Intracellular calcium, preconditioning and regulation of cellular respiration in heart

Liimatta, E. V. (2009) · Cited by 6

Estrogen‐dependent efficacy of limb ischemic preconditioning in female rats

Pócs, L., Janovszky, Á., Garab, D., Terhes, G., Ocsovszki, I., Kaszaki, J., Boros, M., Piffkò, J., & Szabó, A. (2017) · Journal of Orthopaedic Research® · doi:10.1002/jor.23621 · Cited by 5

Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial†

Smenes, B. T., Bækkerud, F. H., Slagsvold, K. H., Hassel, E., Wohlwend, M., Pinho, M. J., Høydal, M. A., Wisløff, U., Rognmo, Ø., & Wahba, A. (2018) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivx439 · Cited by 5

Short-term effects of electrically induced tachycardia on antioxidant defenses in the normal and hypertrophied rat left ventricle

Kłapcińska, B., Sadowska‐Krępa, E., Jagsz, S., Sobczak, A., Żendzian‐Piotrowska, M., Górski, J., & Langfort, J. (2009) · The Journal of Physiological Sciences · doi:10.1007/s12576-009-0026-x · Cited by 5

High-dose metformin treatment to inhibit complex I during early reperfusion protects the aged mouse heart via decreased mitochondrial permeability transition pore opening

Chen, Q., Thompson, J., Hu, Y., Wang, H., Slotabec, L. A., Nguyen, J. D., Rouhi, N., Li, J., & Lesnefsky, E. J. (2024) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2024.100529 · Cited by 6

“Mitochondrial remodeling” in coronary heart disease

Saotome, M., Katoh, H., Satoh, H., Hayashi, H., & Hajnóczky, G. (2014) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s43364 · Cited by 5

Hydroxyl radicals’ production and ECG parameters during ischemia and reperfusion in rat, guinea pig and rabbit isolated heart

Paulová, H., Stračina, T., Jarkovský, J., Novàkovâ, M., & Táborská, E. (2013) · General Physiology and Biophysics · doi:10.4149/gpb_2013016 · Cited by 4

Protective effect of carvacrol from Thymus quinquecostatus Celak against tert-butyl hydroperoxide-induced oxidative damage in Chang cells

Kim, Y.-S., Hwang, J.-W., Sung, S.-H., Park, S., Kim, Y.-T., Kim, E., Moon, S.-H., Jeon, B.-T., & Park, P. (2015) · Food Science and Biotechnology · doi:10.1007/s10068-015-0095-y · Cited by 4

Cardioprotection by poloxamer 188 is mediated through increased endothelial nitric oxide production

Chen, G., Douglas, H. F., Li, Z., Cleveland, W. J., Balzer, C., Yannopoulos, D., Chen, I. Y., Obal, D., & Riess, M. L. (2025) · Scientific Reports · doi:10.1038/s41598-025-97079-z · Cited by 3

Reactive Oxygen Species (ROS) and Cardiac Ischemia and Reperfusion Injury

Camara, A. K. S., & Stowe, D. F. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_75 · Cited by 3

Process of Oxidative Phosphorylation and Free Radical Generation

Stowe, D. F. (2025) · Springer eBooks · doi:10.1007/978-3-031-76668-8_6 · Cited by 2

Dihydrotanshinone I reduces H9c2 cell damage by regulating AKT and MAPK signaling pathways

Wang, Y., Shao, Y.-D., Shao, C.-L., Guan, X.-Q., Lu, P., Ning, K., Liu, B.-N., & Guo, H.-D. (2024) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-023-00839-2 · Cited by 2

Mitochondrial Bioenergetics in the Heart

Lesnefsky, E. J., Chen, Q., Tandler, B., & Hoppel, C. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809657-4.99831-4 · Cited by 2

Reactive Oxygen and Nitrogen Species Production in Cardiomyoblasts During Hypoxia and Hypoxia/Reoxygenation

Kolamunne, R. T., Grant, M. M., Vernallis, A. B., & Griffiths, H. R. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.10.035 · Cited by 1

CARDIOPROTECTION BY PRE- AND POST-CONDITIONING: IMPLICATIONS FOR THE ROLE OF MITOCHONDRIA

Camara, A., Aldakkak, M., Bienengraeber, M., & Stowe, D. F. (2011) · University of Zagreb University Computing Centre (SRCE) · Cited by 1

Focused issue on KATP channels K ATP channels and preconditioning: A re-examination of the role of mitochondrial K ATP channels and an overview of alternative mechanisms

Hanley, P. J., & Daut, J. (2005) · Cited by 1

Differential Expression of CXCL1, CXCL10, and CXCL12 in Response to Cerebral Ischemic Postconditioning in Rat Brain

Tahamtan, M., Shamsizadeh, A., Allahtavakoli, M., Nami, M., Mohammadi, N., & Hassanshahi, G. (2019) · Journal of Advanced Medical Sciences and Applied Technologies · doi:10.32598/jamsat.3.4.197 · Cited by 1

Protective Effect of Apelin, Amlodipine and Anakinra in Ischemia-Reperfusion Injury in Myocardium

Edrees, H. M., Fahmy, E. K., & Abdel-Salam, M. H. (2014) · International Journal of Internal Medicine · Cited by 1

Protective effects of methanolic extract ofOcimum sanctumleaves on mitochondrial dysfunction and damage induced by isoproterenol in hearts of male rats

Kavitha, S. K., Febi, J., & Indira, M. (2015) · Toxicological & Environmental Chemistry Reviews · doi:10.1080/02772248.2015.1110158 · Cited by 1

Co-Enzyme Q10 Protects Rat Heart against Oxidative Stress Induced by Ischemic Reperfusion Injury

Khan, N. A., Chattopadh, P., Pawdey, A., Kishore, K., & Wahi, A. K. (2009) · International Journal of Biological Chemistry · doi:10.3923/ijbc.2010.1.9 · Cited by 1

Hypoxia and the heart : the role of nitric oxide in cardiac myocytes and endothelial cells

Strijdom, H. (2007) · SUNScholar (Stellenbosch University) · Cited by 1

A critical analysis of mitochondrial functioning and associated proteins in obesity-related cardiomyopathy

George, S. (2013) · SUNScholar (Stellenbosch University) · Cited by 1

Preconditioning in the Heart

Hausenloy, D. J., & Yellon, D. M. (2012) · Springer eBooks · doi:10.1007/978-1-4419-9695-4_4

Delayed Anesthetic Preconditioning and Metallothioneins I+II: Novel Mediators of Anesthetic-Induced Protection

Edmands, S. D. (2019) · ScholarWorks@UMassAmherst (University of Massachusetts Amherst) · doi:10.7275/5yh5-sz16

The role of mitochondria in cardioprotection

Heinen, A. (2008) · UvA-DARE (University of Amsterdam)

Gene Expression and Signaling Pathways in Myocardial Ischemia

Marı́n-Garcı́a, J. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9461-5_14

Elucidating the mechanism of cardiac ischemia and reperfusion by proteomics approach

Xin, L. (2011) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/48669

Dietary omega-3 fatty acids, nutritional preconditioning of the heart against ischemic injury

Abdukeyum, G. G. (2010) · Research Online (University of Wollongong)

The antiarrhythmic effect of exogenous peroxynitrite and preconditioning: the involvement of nitric oxide, superoxide and peroxynitrite

Kiss, A. (2011) · doi:10.14232/phd.868

Efeito da suplementação antioxidante sobre o estresse oxidativo induzido pelo exercício - revisão sistemática

Szuck, P., de Almeida Santos, D., Bom, R. P., Navarro, F., & Salgueirosa, F. D. M. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Reducing infarct size by ischemic preconditioning versus insulin treatment in the heart : same outcome - similar mechanisms?

Fuglesteg, B. N. (2008) · NORA - Norwegian Open Research Archives

71 Ischemic damage to the electron transport chain increases the production of reactive oxygen species from isolated rat heart mitochondria

Chen, Q., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.08.075

Isoflurane does not mimic ischaemic preconditioning in decreasing hydroxyl radical production in the rabbit

Gozal, Y., Raphael, J., Rivo, J., Berenshtein, E., Chevion, M., & Drenger, B. (2005) · British Journal of Anaesthesia · doi:10.1093/bja/aei203

posttranslational modifications in mice Antioxidant network expression abrogates oxidative

Ziolo, T., Dwyer, K. M., D'Apice, A. J. F., Zweier, J. L., He, G., Cowan, P. J., Mital, R., Zhang, W., Cai, M., Huttinger, Z. M., et al. (2011)

Characterization of inotropic signaling induced by endogenous peptides apelin and endothelin

Szokodi, I., Koller, Á., & Kovács, L. (2014)

High-altitude hypoxia. A challenging strain targeting cellular redox homeostasis

Magalhães, J., & Ascensão, A. A. M. R. (2008) · Revista Portuguesa de Ciências do Desporto · doi:10.5628/rpcd.08.03.459 · Cited by 1

Triggers and mediators of acute exercise-induced cardioprotection

Taylor, R. P. (2004) · Texas ScholarWorks (Texas Digital Library)

Role of Tumour Necrosis Factor Alpha (TNFa) in ischaemic and pharmacological postconditioning

Lacerda, L. (2010) · Open University of Cape Town (University of Cape Town)

Exploring the cardioprotective effect of synthetic wine in Long Evans rats

Dlamini, L. (2015) · Open University of Cape Town (University of Cape Town)

NADPH Oxidase-dependent ROS Production and Impaired Ca2+ Regulation are Associated with Exercise-induced Cardiac Fatigue in the Rat

Vigna, C. (2015) · UWSpace (University of Waterloo)

Propofol Post-conditioning Protects against COS-7 Cells in Hypoxia/reoxygenation Injury by Induction of Intracellular Autophagy

Kwak, J.-W., Kim, E.-N., Park, B.-S., Kim, Y. H., Kim, Y., Yoon, J.-U., Kim, C.-H., & Yoon, J.-Y. (2014) · Journal of the Korean Dental Society of Anesthesiology · doi:10.17245/jkdsa.2014.14.1.49

Cardiac Na/K-ATPase in ischemia-reperfusion injury and cardioprotection

Duan, Q. (2014) · OhioLink ETD Center (Ohio Library and Information Network)

The role of the mitochondrial permeability transition pore in human myocardial protection

Shanmuganathan, S. (2015) · UCL Discovery (University College London)

The Effect of Acute Docosahexaenoic Acid Intake on Left Ventricular Function and Susceptibility to Ischemia-Reperfusion Injury in the Isolated Rat Heart

Streit, I. T. (2015) · UWSpace (University of Waterloo)

Chloride Channel 2 and Protein Kinase C Epsilon Protein Module in Ischemic Preconditioning of Rabbit Cardiomyocytes

Kuzmin, E. (2010) · TSpace (University of Toronto)

OBSOLETE: Mitochondria Bioenergetics in the Heart

Hoppel, C. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99831-3

Regulation of Bioenergetics in Cardiac Myocytes

Stowe, D. F. (2025) · Springer eBooks · doi:10.1007/978-3-031-76668-8_8

Ionic and Molecular Regulation of Mitochondrial Bioenergetics

Stowe, D. F. (2025) · Springer eBooks · doi:10.1007/978-3-031-76668-8_7

TRP channels in cardiac mechano-redox coupling and diseases

Mi, X., Wu, D., Ito, T., Kato, Y., Nishimura, A., & Nishida, M. (2025) · Journal of Cardiology · doi:10.1016/j.jjcc.2025.02.016

Development of a non-depolarising normakalaemic cardioprotective preservation solution for use in orthotopic heart transplantation

Rudd, D. (2023) · ResearchOnline - JCU (James Cook University) · doi:10.25903/ea7x-vb41

Etude de la signalisation intracellulaire de la cardioprotection vis-à-vis des lésions d'ischémie-reperfusion : implication de GSK-3β, de la voie WNT et de la voie mTOR

Vigneron, F. (2010) · theses.fr (ABES) · doi:10.70675/dc85dc1azbcc2z4311zb705z678accc1150b

Étude de l'effet de nouveaux ligands de la cyclophiline D sur le pore de transition de perméabilité mitochondrial et de leur effet protecteur

Panel, M. (2018) · theses.fr (ABES) · doi:10.70675/d2bc84b3z0f05z4b8eza15fz5ee06082fa4f

Effet protecteur du préconditionnement pharmacologique vis-à-vis de l’ischémie-reperfusion myocardique : Approche mécanistique et clinique

Rozier, R. (2021) · theses.fr (ABES) · doi:10.70675/9c34f2acz300bz4ab2za290zca9f359af6d0

Bioenergetics in the Heart

Lesnefsky, E. J., Chen, Q., Tandler, B., & Hoppel, C. L. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-15734-9.00076-5

The effects of preconditioning coronary artery disease patients with hyperbaric oxygen prior to coronary artery bypass graft surgery & cardiopulmonary bypass

Yogaratnam, J. Z. (2011) · Repository@Hull (Worktribe) (University of Hull)

Characterisation and Mechanism of Bone Marrow Cell-Induced Myocardial Protection

Lai, V. K. (2010) · Leicester Research Archive (University of Leicester)

Role of Reactive Oxygen Species in Ischemic Preconditioning of Subcellular Organelles in the Heart

Saini, H. K., Macháčková, J., & Dhalla, N. (2004) · Antioxidants and Redox Signaling · doi:10.1089/152308604322899468 · Cited by 51

Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption

Zhu, X., Liu, B., Zhou, S., Chen, Y., Deng, Y., Zweier, J. L., & He, G. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00256.2007 · Cited by 43

[Reactive oxygen species are triggers and mediators of an increase in cardiac tolerance to impact of ischemia-reperfusion].

Маслов, Л. Н., Nv, N., Podoksenov, Y. K., Прокудина, Е. С., Gorbunov, A. S., Zhang, I., & Peĭ, Z.-M. (2015) · PubMed · Cited by 13

Reactive oxygen species trigger ischemic and pharmacological postconditioning: In vivo and in vitro characterization

Tsutsumi, Y. M., Yokoyama, T., Horikawa, Y. T., Roth, D. M., & Patel, H. H. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.08.031 · Cited by 141

Ischemic preconditioning enhances scavenging activity of reactive oxygen species and diminishes transmural difference of infarct size

Morihira, M., Hasebe, N., Baljinnyam, E., Sumitomo, K., Matsusaka, T., Izawa, K., Fujino, T., Fukuzawa, J., & Kikuchi, K. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00817.2004 · Cited by 33