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Stem cell mobilization by hyperbaric oxygen
Abstract
We hypothesized that exposure to hyperbaric oxygen (HBO 2) would mobilize stem/progenitor cells from the bone marrow by a nitric oxide (·NO) -dependent mechanism. The population of CD34+cells in the peripheral circulation of humans doubled in response to a single exposure to 2.0 atmospheres absolute (ATA) O 2 for 2 h. Over a course of 20 treatments, circulating CD34+cells increased eightfold, although the overall circulating white cell count was not significantly increased. The number of colony-forming cells (CFCs) increased from 16 ± 2 to 26 ± 3 CFCs/100,000 monocytes plated. Elevations in CFCs were entirely due to the CD34+subpopulation, but increased cell growth only occurred in samples obtained immediately posttreatment. A high proportion of progeny cells express receptors for vascular endothelial growth factor-2 and for stromal-derived growth factor. In mice, HBO 2 increased circulating stem cell factor by 50%, increased the number of circulating cells expressing stem cell antigen-1 and CD34 by 3.4-fold, and doubled the number of CFCs. Bone marrow ·NO concentration increased by 1,008 ± 255 nM in association with HBO 2. Stem cell mobilization did not occur in knockout mice lacking genes for endothelial ·NO synthase. Moreover, pretreatment of wild-type mice with a ·NO synthase inhibitor prevented the HBO 2-induced elevation in stem cell factor and circulating stem cells. We conclude that HBO 2 mobilizes stem/progenitor cells by stimulating ·NO synthesis.
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Cited by
Glover, M., Smerdon, G. R., Andreyev, H. J., Benton, B. E., Bothma, P., Firth, O., Gothard, L., Harrison, J., Ignatescu, M., Laden, G., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00461-1 · Cited by 78
Metadata
- Authors
- Thom, S. R., Bhopale, V. M., Velazquez, O. C., Goldstein, L. J., Thom, L. H., & Buerk, D. G.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2006-04
- Volume
- 290
- Issue
- 4
- Pages
- H1378-H1386
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2130542771
- Cited by
- 288
- References
- 0
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- closed
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