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Some consequences of capillary permeability to macromolecules: Starling's hypothesis reconsidered
Abstract
Starling's hypothesis ascribes fluid movements across capillary walls to the interaction of hydrostatic and colloid osmotic forces. For 90 years it has been recognized as the basis of plasma-to-interstitial fluid balance. Its original statement was based on the notion of capillary impermeability to plasma proteins. However, as knowledge of transcapillary exchange of plasma proteins developed, its formulation was progressively modified to allow for protein transport and for interaction of protein transport with volume flow. The most important aspects of the conceptual evolution of Starling's hypothesis are reviewed in the text of this lecture.
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From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [9]
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“The Patlak equation (Patlak et al., 1963; Curry, 1987; Renkin, 1986) links solute flux across the capillary wall to the Starling hypothesis.”
Background
Metadata
- Authors
- Renkin, E. M.
- Corresponding author
- Renkin, E. M.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 1986-05-01
- Volume
- 250
- Issue
- 5
- Pages
- H706-H710
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2282473666
- Cited by
- 148
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 8 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-18010, HL-10936, HL-17998)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
- Keywords
- capillary permeability, macromolecules, plasma proteins, transcapillary exchange, colloid osmotic pressure, hydrostatic pressure, interstitial fluid, protein trafficking, volumetric flow rate
- MeSH terms
- Capillary Permeability, Models, Cardiovascular, Macromolecular Substances
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