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Pulmonary and peripheral lymph protein clearance during bacteremia after surgery
Abstract
An increase in pulmonary transvascular protein clearance is seen in sheep following postoperative bacteremia. We evaluated whether this increased protein clearance is specific for the lung by comparing in sheep the effect of postoperative bacteremia on both pulmonary and prefemoral lymph protein clearance. Fibronectin, implicated as a factor influencing vascular permeability, was also measured. After intravenous infusion of a sublethal dose of 5 x 10(8) live Pseudomonas aeruginosa (n = 10), pulmonary lymph flow (QL) increased 146% (P less than 0.01), and the lung lymph-to-plasma (L/P) total protein concentration ratio increased 21% (P less than 0.05). This resulted in a 208% elevation (P less than 0.01) in lung protein clearance (LPC = QL x L/P). In contrast, peripheral lymph flow and peripheral protein clearance were not altered. After intravenous infusion of a lethal dose of 5 x 10(9) live Pseudomonas (n = 7), QL rose 243-348% (P less than 0.025), whereas the lung L/P remained at base line, resulting in a 240-358% increase in LPC (P less than 0.025). Again, peripheral lymph flow and protein clearance did not increase. Plasma fibronectin declined slightly after low-dose bacterial challenge but decreased (P less than 0.001) 40% by 4-5 h after high-dose bacterial challenge. After both low- and high-dose bacterial challenge, fibronectin in pulmonary lymph increased (P less than 0.05) relative to total protein. In contrast, no change in peripheral lymph fibronectin was seen. Thu…
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“VEGF expression and increased vascular permeability occur in infection,14, 35 trauma,15, 16, 36 during fetal and postnatal growth,29, 37, 38, 39 preparing for lactation,39, 40 cancer,41, 42 protein‐losing enteropathy,43 and nephrotic syndrome44, 45 (Table 1).”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [15]
In the citing paper
“Other sites (muscle and adipose tissue in collaboration with the liver and, possibly, the kidney12) release these solutes into the vascular compartment from where they enter the extravascular extracellular compartment (interstitium) at increased rates, also facilitated by the increased capillary permeability.4, 13, 14, 15, 16, 17”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [15]
In the citing paper
“Inflammation increases capillary permeability and escape of serum albumin, leading to expansion of interstitial space and increasing the distribution volume of albumin.”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [15]
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Cited by 3
Metadata
- Authors
- Charash, W. E., Saba, T. M., Lewis, E. P., & Lewis, M. A.
- Affiliations
- Albany Medical College (US)
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 1988-12-01
- Volume
- 255
- Issue
- 6
- Pages
- H1421-H1428
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2216685445
- Cited by
- 3
- References
- 0
- Citations by year
- 2021: 1 · 2018: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM-21447, T32GM007033, T32GM07033)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- postoperative bacteremia, lung lymph flow, fibronectin, Pseudomonas aeruginosa, vascular permeability, sheep model
- MeSH terms
- Animals, Blood Pressure, Blood Proteins, Cardiac Output, Fistula, Lung, Lymph, Male, Postoperative Complications, Proteins, Pseudomonas Infections, Reference Values, Sheep, Sepsis
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- CoChat. (2026). Citation check: Pulmonary and peripheral lymph protein clearance during bacteremia after surgery. https://app.cochat.ai/papers/10.1152/ajpheart.1988.255.6.h1421
- The paper
- Charash, W. E., Saba, T. M., Lewis, E. P., & Lewis, M. A. (1988). Pulmonary and peripheral lymph protein clearance during bacteremia after surgery. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.1988.255.6.h1421
