The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Differential atrial and ventricular expression of myocardial BNP during evolution of heart failure
Abstract
Although brain natriuretic peptide (BNP) of myocardial origin is important in cardiovascular and renal function and as a marker of cardiac dysfunction, the expression of BNP in atrial and ventricular myocardium remains controversial both under normal conditions and in heart failure. We therefore determined left atrial and left ventricular (LV) gene expression and tissue concentration as well as circulating BNP during the evolution of rapid ventricular pacing-induced congestive heart failure (CHF) in the dog. Early LV dysfunction after 10 days of pacing was characterized by impaired LV function but maintained arterial pressure, and overt CHF after 38 days of pacing was characterized by further impaired LV function and decreased systemic arterial pressure. Under normal conditions, cardiac BNP mRNA and cardiac tissue BNP were of atrial origin. In early LV dysfunction, BNP mRNA and tissue BNP were markedly increased in the left atrium in association with an increase in circulating BNP but remained below or at the limit of detection in the LV. In overt CHF, BNP mRNA was further increased in the left atrium and first increased in the LV, together with an increase in LV tissue BNP and a further increase in circulating BNP. In the progression of CHF, early LV dysfunction is characterized by a selective increase in atrial BNP expression in association with increased circulating BNP. Overt CHF is characterized by an additional recruitment of ventricular BNP expression and a further increase in circulating BNP. These studies provide important new insight into the local and temporal regulation of cardiac BNP gene expression during the progression of heart failure and underscore the predominant endocrine role of atrial myocardium under normal conditions and in early LV dysfunction.
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Cites
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Cited by
Rapid Measurement of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure
Maisel, A. S., Krishnaswamy, P., Nowak, R. M., McCord, J., Hollander, J. E., Duc, P., Omland, T., Storrow, A. B., Abraham, W. T., Wu, A. H. B., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020233 · Cited by 3,362
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Kazanegra, R., Cheng, V., Garcia, A., Krishnaswamy, P., Gardetto, N., Clopton, P., & Maisel, A. (2001) · Journal of Cardiac Failure · doi:10.1054/jcaf.2001.23355 · Cited by 434
Madamanchi, C., Alhosaini, H., Sumida, A., & Runge, M. S. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.08.007 · Cited by 357
Follistatin-Like 1 in Chronic Systolic Heart Failure: A Marker of Left Ventricular Remodeling
El-Armouche, A., Ouchi, N., Tanaka, K., Doros, G., Wittköpper, K., Schulze, T., Eschenhagen, T., Walsh, K., & Sam, F. (2011) · Circulation Heart Failure · doi:10.1161/circheartfailure.110.960625 · Cited by 76
Metadata
- Authors
- Luchner, A., Stevens, T. L., Borgeson, D. D., Redfield, M., Wei, C.-M., Porter, J. G., & Burnett, J. C.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 1998-05-01
- Volume
- 274
- Issue
- 5
- Pages
- H1684-H1689
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2125804349
- Cited by
- 256
- References
- 21
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Luchner, A., Stevens, T. L., Borgeson, D. D., Redfield, M., Wei, C.-M., Porter, J. G., & Burnett, J. C. (1998). Differential atrial and ventricular expression of myocardial BNP during evolution of heart failure. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.1998.274.5.h1684
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