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Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats
Abstract
We investigated the effects of estrogen on global myocardial ischemia-reperfusion injury in rats that were ovariectomized (Ovx), sham-operated, or ovariectomized and then given 17β-estradiol (E 2 β) supplementation (Ovx+E 2 β). Hearts were excised, cannulated, perfused with and then immersed in chilled (4°C) cardioplegia solution for 30 min, and then retrogradely perfused with warm (37°C), oxygenated Krebs-Henseleit bicarbonate buffer for 120 min. The coronary flow rate, first derivative of left ventricular pressure, and nitrite production were all significantly lower in Ovx than in sham-operated or Ovx+E 2 β hearts. However, coronary flow rates or nitrate production were not consistently different throughout the entire reperfusion period. Ca 2+accumulated more in Ovx rat hearts than in sham-operated or Ovx+E 2 β hearts, and mitochondrial respiratory function was lower in Ovx hearts than in hearts from the other two groups. Marked interstitial edema and contraction bands were seen in hematoxylin-eosin-stained sections of Ovx rat hearts but not in hearts from either of the other groups. Hematoxylin-basic fuchsin-picric acid-stained sections revealed fewer viable myocytes in hearts from the Ovx group than from the sham or Ovx+E 2 β group. Transmission electron microscopy demonstrated more severely damaged mitochondria and ultrastructural damage to myocytes in Ovx rat hearts. Our results indicate that estrogen plays a cardioprotective role in global myocardial ischemia-reperfusion injury in female rats.
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Citations
Cited by
Mechanistic Pathways of Sex Differences in Cardiovascular Disease
Regitz-Zagrosek, V., & Kararigas, G. (2017) · Physiological Reviews · doi:10.1152/physrev.00021.2015 · Cited by 732
Estrogen and the cardiovascular system
Knowlton, A. A., & Lee, A. R. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.03.007 · Cited by 489
Bøtker, H. E., Hausenloy, D., Andreadou, I., Antonucci, S., Boengler, K., Davidson, S. M., Deshwal, S., Devaux, Y., Di Lisa, F., Di Sante, M., et al. (2018) · Basic Research in Cardiology · doi:10.1007/s00395-018-0696-8 · Cited by 423
Sex-Related Differences in Myocardial Remodeling
Piro, M., Della Bona, R., Abbate, A., Biasucci, L. M., & Crea, F. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.09.065 · Cited by 329
Estrogenic control of mitochondrial function and biogenesis
Klinge, C. M. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21936 · Cited by 318
Metadata
- Authors
- Zhai, P., Eurell, T. E., Cotthaus, R., Jeffery, E. H., Bahr, J. M., & Gross, D. R.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2000-12-01
- Volume
- 279
- Issue
- 6
- Pages
- H2766-H2775
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W1803128538
- Cited by
- 180
- References
- 0
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhai, P., Eurell, T. E., Cotthaus, R., Jeffery, E. H., Bahr, J. M., & Gross, D. R. (2000). Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.2000.279.6.h2766
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