The DOI matches its Crossref record.
Blood-brain barrier permeability of 11C-labeled alcohols and 15O-labeled water
Abstract
The extraction of 11C-labeled methanol, ethanol, and isopropanol, as well as 15O-labeled water by the brain during a single capillary transit, was studied in vivo in six adult rhesus monkeys by external detection of the time course of these tracers subsequent to their internal carotid artery injection. The data demonstrate the feasibility of accurately measuring brain permeability of highly diffusible substances by this technique and show that neither water nor the alcohols studied freely equilibrate with brain when the cerebral blood flow exceeds 30 ml/100 g min-1. At a cerebral blood flow of 50 ml/100 g min-1 only about 93% of an injected bolus of labeled water freely exchanges with brain, compared with methanol (93%), ethanol (97%), and isopropanol (99%). The brain capillary permeability-surface area (PS) products computed from these data were 0.023 cm3/s g-1 (water), 0.024 cm3/s g-1 (methanol), 0.030 cm3/s g-1 (ethanol), and 0.062 cm3/s g-1 (isopropanol). This sequence of PS products is consistent with the individual lipid solubilities of the alcohols studied and underscores the unique brain permeability characteristics of lipid-insoluble water.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
Kwong, K. K., Belliveau, J. W., Chesler, D. A., Goldberg, I. E., Weisskoff, R. M., Poncelet, B. P., Kennedy, D. N., Hoppel, B. E., Cohen, M. S., & Turner, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5675 · Cited by 4,212
Mr perfusion studies with t1‐weighted echo planar imaging
Kwong, K. K., Chesler, D. A., Weisskoff, R. M., Donahue, K. M., Davis, T. L., Ostergaard, L., Campbell, T. A., & Rosen, B. R. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340613 · Cited by 477
Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat
Ohno, K., Pettigrew, K. D., & Rapoport, S. I. (1978) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1978.235.3.h299 · Cited by 444
Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study.
Villringer, A., Them, A., Lindauer, U., Einhäupl, K., & Dirnagl, U. (1994) · Circulation Research · doi:10.1161/01.res.75.1.55 · Cited by 295
Johansen, A., Hansen, H. D., Svarer, C., Lehel, S., Leth-Petersen, S., Kristensen, J. L., Gillings, N., & Knudsen, G. M. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17746179 · Cited by 25
Metadata
- Authors
- Raichle, M., Eichling, J., Straatmann, M., Welch, M., Larson, K., & Ter-Pogossian, M.
- Venue
- American Journal of Physiology-Legacy Content
- Publisher
- American Physiological Society
- Published
- 1976-02-01
- Volume
- 230
- Issue
- 2
- Pages
- 543-552
- ISSN
- 0002-9513 (ISSN-L)
- OpenAlex
- W2335787466
- Cited by
- 262
- References
- 0
- FWCI
- 15.25
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Blood-brain barrier permeability of 11C-labeled alcohols and 15O-labeled water. https://app.cochat.ai/papers/10.1152/ajplegacy.1976.230.2.543
- The paper
- Raichle, M., Eichling, J., Straatmann, M., Welch, M., Larson, K., & Ter-Pogossian, M. (1976). Blood-brain barrier permeability of 11C-labeled alcohols and 15O-labeled water. American Journal of Physiology-Legacy Content. https://doi.org/10.1152/ajplegacy.1976.230.2.543
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
