The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure
Abstract
To determine whether disruption of vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) signaling in the newborn has long-term effects on lung structure and function, we injected 1-day-old newborn rat pups with a single dose of Su-5416, a VEGFR inhibitor, or vehicle (controls). Lungs from infant (3-wk-old) and adult (3- to 4-mo-old) rats treated with Su-5416 as newborns showed reductions in arterial density (82 and 31%, respectively) and alveolar counts (45 and 29%) compared with controls. Neonatal treatment with Su-5416 increased right ventricle weight to body wt ratios (4.2-fold and 2.0-fold) and pulmonary arterial wall thickness measurements (2.7-fold and 1.6-fold) in infant and adult rats, respectively, indicating marked pulmonary hypertension. We conclude that treatment of newborn rats with the VEGFR inhibitor Su-5416 impaired pulmonary vascular growth and postnatal alveolarization and caused pulmonary hypertension and that these effects were long term, persisting well into adulthood.
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Cites
The New BPD: An Arrest of Lung Development
Jobe, A. J. (1999) · Pediatric Research · doi:10.1203/00006450-199912000-00007 · Cited by 1,013
Emery, J. L., & Mithal, A. (1960) · Archives of Disease in Childhood · doi:10.1136/adc.35.184.544 · Cited by 432
Cited by
Endothelial Dysfunction in Pulmonary Hypertension
Budhiraja, R., Tuder, R. M., & Hassoun, P. M. (2004) · Circulation · doi:10.1161/01.cir.0000102381.57477.50 · Cited by 768
Self-citationVascular endothelial growth factor in the lung
Voelkel, N. F., Vandivier, R. W., & Tuder, R. M. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00185.2005 · Cited by 403
Self-citationRegulation of the Pulmonary Circulation in the Fetus and Newborn
Gao, Y., & Raj, J. U. (2010) · Physiological Reviews · doi:10.1152/physrev.00032.2009 · Cited by 345
Molecular mechanisms of preeclampsia
Mutter, W. P., & Karumanchi, S. A. (2008) · Microvascular Research · doi:10.1016/j.mvr.2007.04.009 · Cited by 314
Chen, Q., Xu, L., Chen, J., Yang, Z., Liang, C., Yang, Y., & Liu, Z. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.09.021 · Cited by 104
Metadata
- Authors
- Le Cras, T. D., Markham, N. E., Tuder, R. M., Voelkel, N. F., & Abman, S. H.
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2002-09-01
- Volume
- 283
- Issue
- 3
- Pages
- L555-L562
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W2012818083
- Cited by
- 380
- References
- 2
- FWCI
- 13.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Le Cras, T. D., Markham, N. E., Tuder, R. M., Voelkel, N. F., & Abman, S. H. (2002). Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.00408.2001
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