The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Proteoglycans decorin and biglycan differentially modulate TGF-β-mediated fibrotic responses in the lung
Abstract
Transforming growth factor (TGF)-β is a key cytokine in the pathogenesis of pulmonary fibrosis, and pharmacological interference with TGF-β can ameliorate the fibrotic tissue response. The small proteoglycans decorin and biglycan are able to bind and inhibit TGF-β activity in vitro. Although decorin has anti-TGF-β properties in vivo, little is known about the physiological role of biglycan in vivo. Adenoviral gene transfer was used to overexpress active TGF-β, decorin, and biglycan in cell culture and in murine lungs. Both proteoglycans were able to interfere with TGF-β bioactivity in vitro in a dose-dependant manner. In vivo, overexpression of TGF-β resulted in marked lung fibrosis, which was significantly reduced by concomitant overexpression of decorin. Biglycan, however, had no significant effect on lung fibrosis induced by TGF-β. The data suggest that differences in tissue distribution are responsible for the different effects on TGF-β bioactivity in vivo, indicating that decorin, but not biglycan, has potential therapeutic value in fibrotic disorders of the lung.
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Metadata
- Authors
- Kolb, M., Margetts, P. J., Sime, P. J., & Gauldie, J.
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2001-06-01
- Volume
- 280
- Issue
- 6
- Pages
- L1327-L1334
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W2284692617
- Cited by
- 270
- References
- 1
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Proteoglycans decorin and biglycan differentially modulate TGF-β-mediated fibrotic responses in the lung. https://app.cochat.ai/papers/10.1152/ajplung.2001.280.6.l1327
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- Kolb, M., Margetts, P. J., Sime, P. J., & Gauldie, J. (2001). Proteoglycans decorin and biglycan differentially modulate TGF-β-mediated fibrotic responses in the lung. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.2001.280.6.l1327
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