Importance of satellite cells in the strength recovery after eccentric contraction-induced muscle injury
Abstract
The purpose of this study was to determine if the elimination of satellite cell proliferation using gamma-irradiation would inhibit normal force recovery after eccentric contraction-induced muscle injury. Adult female ICR mice were implanted with a stimulating nerve cuff on the common peroneal nerve and assigned to one of four groups: 1) irradiation- and eccentric contraction-induced injury, 2) eccentric contraction-induced injury only, 3) irradiation only, and 4) no intervention. Anterior crural muscles were irradiated with a dose of 2,500 rad and injured with 150 in vivo maximal eccentric contractions. Maximal isometric torque was determined weekly through 35 days postinjury. Immediately after injury, maximal isometric torque was reduced by approximately 50% and had returned to normal by 28 days postinjury in the nonirradiated injured mice. However, torque production of irradiated injured animals did not recover fully and was 25% less than that of injured nonirradiated mice 35 days postinjury. These data suggest that satellite cell proliferation is required for approximately half of the force recovery after eccentric contraction-induced injury.
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Force-producing capabilities of muscle usually return to baseline between 2 and 4 weeks post-eccentric contraction-induced injury.
“The force-producing capabilities of the muscle usually return to baseline (pre-injury) levels between 2 and 4 weeks post-eccentric contraction-induced injury (34, 42, 44, 46, 47).”
From Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice (2021) · cites this paper as [44]
Functional capacity is significantly impaired immediately and for several days after 150 eccentric contractions.
“Here in this study, as with many others (34, 35, 42–44), we reaffirm that functional capacity is significantly impaired immediately, and for several days after, 150 eccentric contractions.”
From Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice (2021) · cites this paper as [44]
Similar findings have been described previously wherein muscle function had recovered, but markers of muscle damage and regeneration, particularly centralized nuclei, are still visible weeks after eccentric contraction-induced muscle damage.
“This is not surprising as similar findings have been described previously wherein muscle function had recovered, but markers of muscle damage and regeneration, particularly centralized nuclei, are still visible weeks after eccentric contraction-induced muscle damage (35, 44).”
From Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice (2021) · cites this paper as [44]
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References 30 · Cited by 77
- Authors
- Rathbone, C. R., Wenke, J. C., Warren, G. L., & Armstrong, R. B.
- Affiliations
- Texas A&M University (US)
- Georgia State University (US)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2003-12
- Volume
- 285
- Issue
- 6
- Pages
- R1490-R1495
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2019186388
- Cited by
- 77
- References
- 30
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 8 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- satellite cells, muscle regeneration, muscle strength recovery, gamma irradiation, satellite cell proliferation, isometric torque, peroneal nerve stimulation, skeletal muscle injury
- MeSH terms
- Animals, Body Weight, Cell Division, Female, Isometric Contraction, Mice, Inbred ICR, Organ Size, Muscle, Skeletal, Muscle Fibers, Skeletal, Torque, Recovery of Function, Satellite Cells, Skeletal Muscle, Mice
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