Species-specific responses to creatine supplementation.
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There are species-specific differences in creatine metabolism and storage, so results from mice or rat data cannot be directly extrapolated to human creatine oral dosing studies.
“it is well-known that there are species specific differences in creatine metabolism and storage [200]. Therefore, you cannot directly extrapolate results from mice or rat data to human creatine oral dosing studies.”
From Bioavailability, Efficacy, Safety, and Regulatory Status of Creatine and Related Compounds: A Critical Review (2022) · cites this paper as [200]
Cites
Creatine Supplementation Increases Renal Disease Progression in Han:SPRD-cy Rats
Edmunds, J. W., Jayapalan, S., DiMarco, N. M., Saboorian, H., & Aukema, H. M. (2001) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2001.20590 · Cited by 58 · cited 1× · see citing works
“Although recent studies examining the safety of creatine in humans have not substantiated these concerns (2, 4–7), several reports have indicated that long-term creatine supplementation in mice may alter liver pathology (3) and/or promote renal disease progression in hypertensive rats (Han:SPRD) (1).”
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Dolan, E., Gualano, B., & Rawson, E. S. (2019) · European Journal of Sport Science · doi:10.1080/17461391.2018.1500644 · Cited by 171 · see citing works
Kreider, R. B., Jäger, R., & Purpura, M. (2022) · Nutrients · doi:10.3390/nu14051035 · Cited by 103 · see citing works
Self-citationGualano, B., Ugrinowitsch, C., Novaes, R. B., Artioli, G. G., Shimizu, M. H., Seguro, A. C., Harris, R. C., & Lancha, A. H. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0669-3 · Cited by 88 · see citing works
Safety of Creatine Supplementation
Persky, A. M., & Rawson, E. S. (2007) · Subcellular Biochemistry · doi:10.1007/978-1-4020-6486-9_14 · Cited by 60 · see citing works
- Authors
- Kreider, R. B.
- Affiliations
- Baylor University (US)
- Corresponding author
- Kreider, Richard B.
- ORCID
- Kreider, Richard B.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2003-10
- Volume
- 285
- Issue
- 4
- Pages
- R725-R726
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2157861334
- Cited by
- 27
- References
- 1
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 2 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Medicine › Physiology › Biochemical effects in animals
- Keywords
- creatine supplementation, species differences, creatine metabolism, creatine kinase, exercise performance
- MeSH terms
- Animals, Creatinine, Humans, Species Specificity, Dietary Supplements, Models, Animal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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