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Long-term cannulation model for blood sampling and intragastric infusion in the rat
Abstract
An improved methodology is described for long-term venous and gastric cannulation in the rat. The long-term efficacy of the cannulas for blood sampling and intragastric infusion of liquid diet was determined in 18 rats. No animals died after surgery, and weight gain was normal. During the first 6 wk, blood could be drawn repetitively in 94% of the rats, and continuous intragastric infusion of diet was maintained in all the animals. For an extended period of 11 wk, success rates for blood sampling and dietary infusion were 75 and 100%, respectively. Standard hematological, histopathological, and clinical laboratory tests showed no abnormal changes. Furthermore, plasma corticosterone levels were consistently low (0.5 +/- 0.11 to 1.52 +/- 0.55 micrograms/dl) from the third postoperative day throughout a period of 6 wk, indicating that animals were under minimal stress.
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Cited by
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Kono, H., Rusyn, I., Yin, M., Gäbele, E., Yamashina, S., Dikalova, A., Kadiiska, M. B., Connor, H. D., Mason, R. P., Segal, B. H., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9020 · Cited by 493
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Metadata
- Authors
- Tsukamoto, H., Reidelberger, R. D., French, S. W., & Largman, C.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1984-09-01
- Volume
- 247
- Issue
- 3
- Pages
- R595-R599
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2220673278
- Cited by
- 179
- References
- 0
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tsukamoto, H., Reidelberger, R. D., French, S. W., & Largman, C. (1984). Long-term cannulation model for blood sampling and intragastric infusion in the rat. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.1984.247.3.r595
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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