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Role of interleukin 6 in fever in rats
Abstract
The purpose of these studies was to assess whether interleukin 6 (IL-6) is an endogenous pyrogen, responsible for all or part of the fever caused by lipopolysaccharide (LPS) in rats. We have found that the core temperature (as measured by biotelemetry) rose significantly after intracerebroventricular (icv) injection of recombinant human IL-6. The same doses of IL-6, when administered intravenously or intraperitoneally, had no effect on body temperature. The fever caused by icv administration of IL-6 was completely blocked by indomethacin. After injection of fever-inducing doses of LPS, the plasma and cerebrospinal fluid (CSF) IL-6 activities rose, the former much more than the latter. The correlation between fever and plasma IL-6 activity was r = 0.84 (P less than 0.0025); the correlation between fever and CSF IL-6 activity was r = 0.77 (P less than 0.015). The results of this study are consistent with the hypothesis that IL-6 is a mediator of LPS-induced fever in the rat.
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Citations
Cited by
Hodes, G. E., Pfau, M. L., Leboeuf, M., Golden, S. A., Christoffel, D. J., Bregman, D., Rebusi, N., Heshmati, M., Aleyasin, H., Warren, B. L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415191111 · Cited by 692
Penetration of interleukin-6 across the murine blood-brain barrier
Banks, W. A., Kastin, A. J., & Gutierrez, E. G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90933-4 · Cited by 485
Conti, B. (2004) · Frontiers in Bioscience · doi:10.2741/1341 · Cited by 408
Cellular Localization of Interleukin 6 mRNA and Interleukin 6 Receptor mRNA in Rat Brain
Schöbitz, B., de Kloet, E. R., Sutanto, W., & Holsboer, F. (1993) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1993.tb00210.x · Cited by 329
Zhu, Z., Tang, W., Ray, A., Wu, Y., Einarsson, O., Landry, M. L., Gwaltney, J., & Elias, J. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118431 · Cited by 282
Metadata
- Authors
- LeMay, L. G., Vander, A. J., & Kluger, M. J.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1990-03-01
- Volume
- 258
- Issue
- 3
- Pages
- R798-R803
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2278896431
- Cited by
- 225
- References
- 0
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- LeMay, L. G., Vander, A. J., & Kluger, M. J. (1990). Role of interleukin 6 in fever in rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.1990.258.3.r798
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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