The DOI matches its Crossref record.
Model of spontaneous obesity in aging male Wistar rats
Abstract
We analyzed retrospectively data from 148 chow-fed male Wistar rats killed between the age of 6 wk and 2 yr while varying in body weight from 136 to 917 g. The purpose of this study was to clarify the relationship of body weight and body lipid content with the composition and cellularity of the epididymal and retroperitoneal fat depots. A positive linear association was found between body weight and body water or fat-free dry residue, whereas total body lipid exhibited a curvilinear relationship with body weight. The weight of the epididymal pads was linearly related to body weight but not to body lipid. In contrast, retroperitoneal pad weight was exponentially related to body weight and paralleled total body lipid. A strong linear correlation was found between total body lipid and weight (r = 0.959) or depot lipid content (r = 0.967) of the retroperitoneal fat pads. In this rat model of aging and spontaneous obesity, significant regional differences exist in adipose depot composition and cellularity. A practical outcome of this study is a simple and accurate prediction of body lipid content from the gravimetric determination of the retroperitoneal fat depots.
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Wistar rats spontaneously develop obesity as they age.
“Because Wistar rats spontaneously develop obesity as they age (Newby et al. 1990), chronic 3,5-T2 administration could be beneficial.”
From Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues (2014) · cites this paper as Newby et al. 1990
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Kirkland, J. L., & Dobson, D. E. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb02967.x · Cited by 105
Padron, A. S., Neto, R. A. L., Pantaleão, T. U., de Souza dos Santos, M. C., Araujo, R. L., de Andrade, B. M., da Silva Leandro, M., de Castro, J. P. S. W., Ferreira, A. C. F., & de Carvalho, D. P. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0502 · Cited by 69
Metadata
- Authors
- Newby, F. D., DiGirolamo, M., Cotsonis, G. A., & Kutner, M. H.
- Affiliations
- Emory University (US)
- ORCID
- Kutner, M. H.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1990-12-01
- Volume
- 259
- Issue
- 6
- Pages
- R1117-R1125
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W1922643401
- Cited by
- 64
- References
- 0
- Citations by year
- 2025: 2 · 2023: 1 · 2021: 2 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (1RO1 AG-00789)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK039326)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- aging, Wistar rats, epididymal adipose tissue, retroperitoneal fat, adipose tissue composition, adipocyte cellularity, body fat content, body weight, fat pad weight, total body water
- MeSH terms
- Adipose Tissue, Aging, Animals, Body Composition, Body Water, Body Weight, Cell Count, Disease Models, Animal, Energy Metabolism, Epididymis, Male, Obesity, Rats, Inbred Strains, Retroperitoneal Space, Lipid Metabolism, Rats
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