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Cited by 491

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Dietary obesity in nine inbred mouse strains

West, D. B., Boozer, C. N., Moody, D. L., Atkinson, R. L.·1992·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Abstract

The effect of 7 wk consumption of a diet containing 32.6% of kilocalories as fat [condensed milk (CM) diet] on body composition and energy intake was evaluated in nine strains of inbred mice (AKR/J, C57L/J, A/J, C3H/HeJ, DBA/2J, C57BL/6J, SJL/J, I/STN, and SWR/J). Control animals were fed a high-carbohydrate diet containing 11.6% of energy as fat (Purina Rodent Chow diet). Relative to Chow diet controls, the CM diet significantly increased carcass lipid content in six strains (AKR/J, C57L/J, A/J, C3H/HeJ, DBA/2J, and C57BL/6J), but had no or a marginal effect on adiposity in three strains of mice (SJL/J, I/STN, and SWR/J). The obesity produced by the CM diet in six strains was not due to hyperphagia. Only one of six (AKR/J) of the strains that increased adiposity on the CM diet consumed more energy than controls during the 7 wk of the experiment. The identification of inbred mouse strains that are sensitive to dietary obesity, vs. others that are resistant, provides a useful tool to pursue the metabolic and genetic basis of this trait in the mouse.

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Crossref · 10.1152/ajpregu.1992.262.6.r1025

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Metadata

Authors
West, D. B., Boozer, C. N., Moody, D. L., & Atkinson, R. L.
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Published
1992-06-01
Volume
262
Issue
6
Pages
R1025-R1032
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
OpenAlex
W2187321354
Cited by
491
References
2
FWCI
3.06
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Dietary obesity in nine inbred mouse strains. https://app.cochat.ai/papers/10.1152/ajpregu.1992.262.6.r1025
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West, D. B., Boozer, C. N., Moody, D. L., & Atkinson, R. L. (1992). Dietary obesity in nine inbred mouse strains. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.1992.262.6.r1025

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