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Exercise-induced sympathetic FFA mobilization in VMH-lesioned rats is normalized by fasting
Open accessAbstract
This study investigates whether reduced sympathetic responses during physical exercise in ventromedial hypothalamus (VMH)-lesioned obese rats are the direct result of damage to hypothalamic circuits or a secondary effect of the altered metabolism in obesity. Obese, VMH-lesioned rats and lean controls were deprived of food for 48 h and submitted to 15 min of swimming. Food-deprived lean and obese rats displayed increased free fatty acid mobilization and utilization, whereas blood glucose concentrations were decreased. Basal plasma insulin levels were reduced by fasting in both groups, when compared with the ad libitum situation, but remained higher in the obese animals. Fasting augmented the norepinephrine response of the obese rats, resulting in equal profiles in lean and obese animals. These results indicate that VMH-lesioned animals are able to increase the sympathetic activation of adipose tissue during exercise to overcome an energy deficiency. Therefore, the function of the VMH in the regulation of the sympathetic nervous system controlling metabolism can be taken over by redundant mechanisms. The reduced sympathetic activity in ad libitum fed VMH-lesioned animals is therefore likely to be the result of the altered metabolism.
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“VMH is a key nucleus of the energy homeostasis regulatory system in the hypothalamus, which is deeply involved in the SNS output and lipolysis regulation [46].”
From High-intensity interval training or lactate administration combined with aerobic training enhances visceral fat loss while promoting VMH neuroplasticity in female rats (2024) · cites this paper as [46]
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Cited by 15
Metadata
- Authors
- Balkan, B., Van Dijk, G., Strubbe, J. H., Bruggink, J. E., & Steffens, A. B.
- Affiliations
- University of Groningen (NL)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1992-06-01
- Volume
- 262
- Issue
- 6
- Pages
- R981-R985
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W1821519937
- Cited by
- 15
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2021: 1 · 2020: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- green
- research.rug.nl
- Licence
- other-oa
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- ventromedial hypothalamus, hypothalamic lesions, obesity, free fatty acid mobilization, physical activity, fasting, sympathetic nervous system, norepinephrine, adipose tissue, insulin, blood glucose, energy deficiency
- MeSH terms
- Animals, Blood Glucose, Epinephrine, Physical Exertion, Fasting, Fatty Acids, Nonesterified, Insulin, Male, Norepinephrine, Osmolar Concentration, Rats, Inbred Strains, Reference Values, Sympathetic Nervous System, Ventromedial Hypothalamic Nucleus, Rats
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- CoChat. (2026). Citation check: Exercise-induced sympathetic FFA mobilization in VMH-lesioned rats is normalized by fasting. https://app.cochat.ai/papers/10.1152/ajpregu.1992.262.6.r981
- The paper
- Balkan, B., Van Dijk, G., Strubbe, J. H., Bruggink, J. E., & Steffens, A. B. (1992). Exercise-induced sympathetic FFA mobilization in VMH-lesioned rats is normalized by fasting. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.1992.262.6.r981
