Temporal cascade of plasma level surges in ACTH, corticosterone, and cytokines in endotoxin-challenged rats
Abstract
The present study was designed to investigate the coupling mechanisms linking the immune and the neuroendocrine corticotropic systems in an integrated defense response triggered by an infectious aggression. The experimental paradigm used consisted of the exploration in individual conscious rats of the temporal pattern of increased plasma concentrations of the two stress hormones, adrenocorticotropic hormone (ACTH) and corticosterone (Cort), and of three cytokines known as ACTH stimulators, tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6, after intra-arterial infusions of lipopolysaccharide (LPS) given at three doses, 5 micrograms/kg (LPS-5), 25 micrograms/kg (LPS-25), and 1 mg/kg (LPS-1,000). Blood samples were taken 30 min and immediately before LPS injection (t0) and at 15, 30, 60, 120, 300, and 480 min post-LPS. The three doses of LPS induced ACTH and Cort surges, starting after 30 min for LPS-5 and LPS-25 or 15 min for LPS-1,000 and peaking with a similar amplitude at 60 min before receding slowly to baseline at 480 min for the two lower LPS doses. On the other hand, whatever the LPS dose, none of the three cytokines rose above undetectable basal levels before 60 min. They increased thereafter to culminate 10- to 30-fold above baseline at 60 min (TNF-alpha) or 120 min (IL-1 beta and IL-6) after LPS and declined back to basal levels at 300 min (TNF-alpha, all doses, and IL-6 for LPS-5 and LPS-25). After LPS-25, only IL-1 beta had not regressed to…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cited by
Sorted by citations
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297 · see citing works
Bethin, K. E., Vogt, S. K., & Muglia, L. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9317 · Cited by 382 · see citing works
TNF-α impairs heart and skeletal muscle protein synthesis by altering translation initiation
Lang, C. H., Frost, R. A., Nairn, A. C., MacLean, D. A., & Vary, T. C. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00366.2001 · Cited by 265 · see citing works
Lacroix, S., Feinstein, D., & Rivest, S. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00189.x · Cited by 223 · see citing works
Vallières, L., & Rivest, S. (1999) · Endocrinology · doi:10.1210/endo.140.9.6983 · Cited by 157 · see citing works
Barrientos, R. M., Frank, M. G., Crysdale, N. Y., Chapman, T. R., Ahrendsen, J. T., Day, H. E. W., Campeau, S., Watkins, L. R., Patterson, S. L., & Maier, S. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2266-11.2011 · Cited by 148 · see citing works
Neurodevelopmental damage after prenatal infection: role of oxidative stress in the fetal brain
Lanté, F., Meunier, J., Guiramand, J., Maurice, T., Cavalier, M., de Jesus Ferreira, M.-C., Aimar, R., Cohen-Solal, C., Vignes, M., & Barbanel, G. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.01.027 · Cited by 140 · see citing works
Lanté, F., Meunier, J., Guiramand, J., De Jesus Ferreira, M., Cambonie, G., Aimar, R., Cohen‐Solal, C., Maurice, T., Vignes, M., & Barbanel, G. (2008) · Hippocampus · doi:10.1002/hipo.20421 · Cited by 124 · see citing works
Self-citationTurnbull, A. V., & Rivier, C. (1996) · Endocrinology · doi:10.1210/endo.137.2.8593789 · Cited by 95 · see citing works
Dynamic Pituitary-Adrenal Interactions in Response to Cardiac Surgery*
Gibbison, B., Spiga, F., Walker, J. J., Russell, G. M., Stevenson, K., Kershaw, Y., Zhao, Z., Henley, D., Angelini, G. D., & Lightman, S. L. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000773 · Cited by 87 · see citing works
Engström, L., Rosén, K., Angel, A., Fyrberg, A., Mackerlova, L., Konsman, J. P., Engblom, D., & Blomqvist, A. (2008) · Endocrinology · doi:10.1210/en.2007-1456 · Cited by 69 · see citing works
Dynamic responses of the adrenal steroidogenic regulatory network
Spiga, F., Zavala, E., Walker, J. J., Zhao, Z., Terry, J. R., & Lightman, S. L. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703779114 · Cited by 52 · see citing works
- Authors
- Givalois, L., Dornand, J., Mekaouche, M., Solier, M. D., Bristow, A. F., Ixart, G., Siaud, P., Assenmacher, I., & Barbanel, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Givalois, L.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1994-07-01
- Volume
- 267
- Issue
- 1
- Pages
- R164-R170
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2286576123
- Cited by
- 249
- References
- 0
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 5 · 2012: 7
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- lipopolysaccharide, endotoxemia, corticosterone, cytokines, TNF-α, IL-1β, interleukin-6, neuroendocrine-immune interaction, stress hormones, dose-response relationship
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Corticosterone, Dose-Response Relationship, Drug, Endotoxins, Escherichia coli, Injections, Lipopolysaccharides, Male, Time Factors, Cytokines, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
