Fibroblast growth factor 23 leads to endolysosomal routing of the renal phosphate cotransporters NaPi-IIa and NaPi-IIc in vivo
Abstract
The hormone fibroblast growth factor 23 (FGF23) controls phosphate homeostasis by regulating renal phosphate excretion. FGF23 acts on several phosphate transporters in the kidney. Here, we define the time course of this action and demonstrate how phosphate transporters NaPi-IIa and NaPi-IIc are degraded.
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Increased dietary inorganic phosphate (Pi) intake stimulates renal Pi excretion, in part, by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23) or dopamine.
“Increased dietary inorganic phosphate (Pi) intake stimulates renal Pi excretion, in part, by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23) or dopamine.”
From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [33]
The activity of NaPi-IIa and NaPi-IIc is highly regulated by PTH, FGF23, dopamine, calcitriol, glucocorticoids, growth hormone, potassium, or acid-base status.
“The activity of NaPi-IIa and NaPi-IIc is highly regulated by a variety of hormones and factors that include parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), dopamine, calcitriol, glucocorticoids, growth hormone, potassium, or acid–base status [3, 11, 33, 37].”
From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [33]
Lower calcitriol levels likely reflect suppression of the calcitriol-synthesizing enzyme CYP27B1 and stimulation of the catabolic CYP24A1 enzyme by iFGF23, as observed in animal studies.
“lower calcitriol levels likely reflecting the suppression of calcitriol synthesizing enzyme CYP27B1 and stimulation of the catabolic CYP24A1 enzyme by iFGF23 as observed in animal studies [31, 33, 51].”
From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [33]
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References 57 · Cited by 38
- Authors
- Küng, C. J., Haykir, B., Schnitzbauer, U., Egli-Spichtig, D., Hernando, N., & Wagner, C. A.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Wagner, Carsten A.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2021-12-01
- Volume
- 321
- Issue
- 6
- Pages
- F785-F798
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W3209097188
- Cited by
- 38
- References
- 57
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 9 · 2023: 9 · 2022: 4
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (176125)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Nephrology › Renal function and acid-base balance
- Keywords
- fibroblast growth factor 23, NaPi-IIa, NaPi-IIc, phosphate homeostasis, endolysosomal trafficking, transporter internalization, renal phosphate excretion, kidney
- MeSH terms
- Fibroblast Growth Factor-23, Animals, Fibroblast Growth Factors, Kidney, Kidney Tubules, Proximal, Lysosomes, Parathyroid Hormone, Phosphates, Endosomes, Sodium-Phosphate Cotransporter Proteins, Type IIa, Mice
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