The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury
Abstract
Heme oxygenases (HOs) catalyze the rate-limiting step in heme degradation, resulting in the formation of iron, carbon monoxide, and biliverdin, the latter of which is subsequently converted to bilirubin by biliverdin reductase. Recent attention has focused on the biological effects of product(s) of this enzymatic reaction, which have important antioxidant, anti-inflammatory, and cytoprotective functions. Two major isoforms of the HO enzyme have been described: an inducible isoform, HO-1, and a constitutively expressed isoform, HO-2. A third isoform, HO-3, closely related to HO-2, has also been described. Several stimuli implicated in the pathogenesis of renal injury, such as heme, nitric oxide, growth factors, angiotensin II, cytokines, and nephrotoxins, induce HO-1. Induction of HO-1 occurs as an adaptive and beneficial response to these stimuli, as demonstrated by studies in renal and non-renal disease states. This review will focus on the molecular regulation of the HO-1 gene in renal injury and will highlight the interspecies differences, predominantly between the rodent and human HO-1 genes.
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Cited by
Mechanisms of Cell Protection by Heme Oxygenase-1
Gozzelino, R., Jeney, V., & Soares, M. P. (2010) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105600 · Cited by 1,241
Update on Mechanisms of Ischemic Acute Kidney Injury
Devarajan, P. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006010017 · Cited by 1,026
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Wu, L., & Wang, R. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.3 · Cited by 962
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Metadata
- Authors
- Sikorski, E. M., Hock, T., Hill-Kapturczak, N., & Agarwal, A.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2004-03
- Volume
- 286
- Issue
- 3
- Pages
- F425-F441
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2054496846
- Cited by
- 238
- References
- 9
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sikorski, E. M., Hock, T., Hill-Kapturczak, N., & Agarwal, A. (2004). The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury. American Journal of Physiology-Renal Physiology. https://doi.org/10.1152/ajprenal.00297.2003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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