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Cited by 76Ion Transport and Channel RegulationParathyroid Disorders and TreatmentsReceptor Mechanisms and Signaling

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Activation of dopamine D 1 -like receptors induces acute internalization of the renal Na + /phosphate cotransporter NaPi-IIa in mouse kidney and OK cells

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Bacic, Desa, Capuano, Paola, Baum, Michel, Zhang, Jianning, Stange, Gerti, Biber, Jürg, Kaissling, Brigitte, Moe, Orson W., Wagner, Carsten A., Murer, Heini·2005·American Journal of Physiology-Renal Physiology
DOI 10.1152/ajprenal.00380.2004PMC PMC4133138
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Abstract

The Na + /phosphate cotransporter NaPi-IIa (SLC34A1) is the major transporter mediating the reabsorption of P i in the proximal tubule. Expression and activity of NaPi-IIa is regulated by several factors, including parathyroid hormone, dopamine, metabolic acidosis, and dietary P i intake. Dopamine induces natriuresis and phosphaturia in vivo, and its actions on several Na + -transporting systems such as NHE3 and Na + -K + -ATPase have been investigated in detail. Using freshly isolated mouse kidney slices, perfused proximal tubules, and cultured renal epithelial cells, we examined the acute effects of dopamine on NaPi-IIa expression and localization. Incubation of isolated kidney slices with the selective D 1 -like receptor agonists fenoldopam (10 μM) and SKF-38393 (10 μM) for 1 h induced NaPi-IIa internalization and reduced expression of NaPi-IIa in the brush border membrane (BBM). The D 2 -like selective agonist quinpirole (1 μM) had no effect. The D 1 and D 2 agonists did not affect the renal Na + /sulfate cotransporter NaSi in the BBM of the proximal tubule. Studies with isolated perfused proximal tubules demonstrated that activation of luminal, but not basolateral, D 1 -like receptors caused NaPi-IIa internalization. In kidney slices, inhibition of PKC (1 μM chelerythrine) or ERK1/2 (20 μM PD-098089) pathways did not prevent the fenoldopam-induced internalization. Inhibition with the PKA blocker H-89 (10 μM) abolished the effect of fenoldopam. Immunoblot demonstrated a reduction of NaPi-IIa protein in BBMs from kidney slices treated with fenoldopam. Incubation of opossum kidney cells transfected with NaPi-IIa-green fluorescent protein chimera shifted fluorescence from the apical membrane to an intracellular pool. In summary, dopamine induces internalization of NaPi-IIa by activation of luminal D 1 -like receptors, an effect that is mediated by PKA.

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Crossref · 10.1152/ajprenal.00380.2004

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  • Increased dietary inorganic phosphate (Pi) intake stimulates renal Pi excretion, in part, by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23) or dopamine.

    “Increased dietary inorganic phosphate (Pi) intake stimulates renal Pi excretion, in part, by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23) or dopamine.”

    From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [3]

  • The activity of NaPi-IIa and NaPi-IIc is highly regulated by PTH, FGF23, dopamine, calcitriol, glucocorticoids, growth hormone, potassium, or acid-base status.

    “The activity of NaPi-IIa and NaPi-IIc is highly regulated by a variety of hormones and factors that include parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), dopamine, calcitriol, glucocorticoids, growth hormone, potassium, or acid–base status [3, 11, 33, 37].”

    From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [3]

  • Dopamine and aldosterone have been linked to phosphate homeostasis.

    “Last we measured also other hormones that have been linked to phosphate homeostasis such as dopamine and aldosterone [3, 10, 12, 13, 24, 47, 57, 61, 62].”

    From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [3]

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Metadata

Authors
Bacic, D., Capuano, P., Baum, M., Zhang, J., Stange, G., Biber, J., Kaissling, B., Moe, O. W., Wagner, C. A., & Murer, H.
Affiliations
  • University of Zurich (CH)
  • Neurology, Inc (US)
  • The University of Texas Southwestern Medical Center (US)
ORCID
Venue
American Journal of Physiology-Renal Physiology
Publisher
American Physiological Society
Published
2005-04
Volume
288
Issue
4
Pages
F740-F747
ISSN
  • 1522-1466 (ISSN-L)
  • 1931-857X
DOI
10.1152/ajprenal.00380.2004
PMC
PMC4133138
OpenAlex
W2050088532
Cited by
76
References
1
Citations by year
2026: 3 · 2024: 1 · 2023: 3 · 2022: 1 · 2020: 4 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 7 · 2012: 11
FWCI
1.31
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Renal Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Funders
  • U.S. Public Health Service (P01-20543, R01 48482)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK41612, R01DK041612)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
D1-like receptors, NaPi-IIa, SLC34A1, receptor internalization, proximal tubule, brush border membrane, phosphaturia, fenoldopam, protein kinase A, phospholipase C, ERK1/2, renal phosphate reabsorption, opossum kidney cells
MeSH terms
Animals, Cells, Cultured, Endocytosis, Kidney Tubules, Proximal, Male, Mice, Inbred C57BL, Microvilli, Opossums, Organ Culture Techniques, Down-Regulation, Cell Polarity, Receptors, Dopamine D1, Receptors, Dopamine D2, Cyclic AMP-Dependent Protein Kinases, Dopamine Agonists, Fenoldopam, Quinpirole, Symporters, Sodium-Phosphate Cotransporter Proteins, Sodium-Phosphate Cotransporter Proteins, Type IIa, Mice

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