The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule
Abstract
The purpose of this study was to evaluate the physiological significance of a tissue renin-angiotensin system in the proximal tubule of the kidney. To accomplish this, we produced mice that express human renin (hREN) under the control of the kidney androgen-regulated promoter (KAP), which is androgen responsive. One of the lines expressed the hREN transgene primarily in the kidney. Renal expression of the transgene was undetectable in females but could be induced by testosterone treatment. Because the renin-angiotensin system is species specific, we bred KAP2-hREN mice with the mice expressing human angiotensinogen under the same promoter (KAP-hAGT) to produce offspring that expressed both transgenes. We measured mean arterial blood pressure (MAP) in the carotid artery of double-transgenic and control mice using radiotelemetry. Double-transgenic female mice had a normal baseline MAP (116 ± 4 mmHg, n = 8), which increased by 15 mmHg after 2 wk of testosterone treatment, and returned to baseline after elimination of the testosterone pellet. The change in arterial pressure paralleled the change in plasma testosterone. There was no MAP change in testosterone-treated control littermates. We conclude that dual production of renin and angiotensinogen in the renal proximal tubule can result in a systemic increase in arterial pressure. These data support a role for a tissue-specific renin-angiotensin system in the renal proximal tubule that contributes to the regulation of systemic blood pressure.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Since Angiotensin-I is an intermediary peptide found most abundant as inactive form in blood (Lavoie et al., 2004), it is not surprising that we were able to detect the increased level of angiotensin I in blood as well as kidney where the cleavage of angiotensinogen takes place.”
From Lysosomal Cathepsin A Plays a Significant Role in the Processing of Endogenous Bioactive Peptides (2016) · cites this paper as Lavoie et al., 2004
Citations
Cites
Nguyen, G., Delarue, F., Burcklé, C., Bouzhir-Sima, L., Giller, T., & Sraer, J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14276 · Cited by 1,276
Shimkets, R. A., Warnock, D. G., Bositis, C. M., Nelson-Williams, C., Hansson, J. H., Schambelan, M., Gill, J. R., Ulick, S., Milora, R. V., Findling, J. W., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90250-x · Cited by 1,259
Simon, D. B., Nelson-Williams, C., Johnson Bia, M., Ellison, D., Karet, F. E., Morey Molina, A., Vaara, I., Iwata, F., Cushner, H. M., Koolen, M., et al. (1996) · Nature Genetics · doi:10.1038/ng0196-24 · Cited by 1,219
Nguyen, G., Delarue, F., Burcklé, C., Bouzhir, L., Giller, T., & Sraer, J.-D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214276 · Cited by 1,137
Ingelfinger, J. R., Zuo, W. M., Fon, E. A., Ellison, K. E., & Dzau, V. J. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114454 · Cited by 325
Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis.
Danser, A. H., van Kats, J. P., Admiraal, P. J., Derkx, F. H., Lamers, J. M., Verdouw, P. D., Saxena, P. R., & Schalekamp, M. A. (1994) · Hypertension · doi:10.1161/01.hyp.24.1.37 · Cited by 311
Angiotensin II Directly Stimulates ENaC Activity in the Cortical Collecting Duct via AT1 Receptors
Peti-Peterdi, J., Warnock, D. G., & Bell, P. D. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000013292.78621.fd · Cited by 298
Elements of a Paracrine Tubular Renin-Angiotensin System Along the Entire Nephron
Rohrwasser, A., Morgan, T. K., Dillon, H. F., Zhao, L., Callaway, C. W., Hillas, E., Zhang, S., Cheng, T., Inagami, T., Ward, K. J., et al. (1999) · Hypertension · doi:10.1161/01.hyp.34.6.1265 · Cited by 287
Angiotensin II: a powerful controller of sodium transport in the early proximal tubule.
Cogan, M. G. (1990) · Hypertension · doi:10.1161/01.hyp.15.5.451 · Cited by 243
Merrill, D., Thompson, M. W., Carney, C., Granwehr, B. P., Schlager, G., Robillard, J., & Sigmund, C. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118497 · Cited by 188
Self-citation
Cited by
Seyrantepe, V., Hinek, A., Peng, J., Fedjaev, M., Ernest, S., Kadota, Y., Canuel, M., Itoh, K., Morales, C. R., Lavoie, J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.733212 · Cited by 112
Self-citationLysosomal Cathepsin A Plays a Significant Role in the Processing of Endogenous Bioactive Peptides
Timur, Z. K., Akyildiz Demir, S., & Seyrantepe, V. (2016) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2016.00068 · Cited by 38
Metadata
- Authors
- Lavoie, J. L., Lake-Bruse, K. D., & Sigmund, C. D.
- Affiliations
- Departments of Internal Medicine and Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2004-05
- Volume
- 286
- Issue
- 5
- Pages
- F965-F971
- ISSN
- 1931-857X
- 1522-1466
- Cited by
- 94
- References
- 49
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
