Renal nerve stimulation leads to the activation of the Na+/H+exchanger isoform 3 via angiotensin II type I receptor

Pontes, Roberto B.; Crajoinas, Renato O.; Nishi, Erika E.; Oliveira-Sales, Elizabeth B.; Girardi, Adriana C.; Campos, Ruy R.; Bergamaschi, Cássia T.

doi:10.1152/ajprenal.00515.2014

Renal nerve stimulation leads to the activation of the Na+/H+exchanger isoform 3 via angiotensin II type I receptor

Renal nerve stimulation at a low frequency (below 2 Hz) causes water and sodium reabsorption via α 1 -adrenoreceptor tubular activation, a process independent of changes in systemic blood pressure, renal blood flow, or glomerular filtration rate. However, the underlying mechanism of the reabsorpt…