The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Mechanism of active chloride secretion by shark rectal gland: role of Na-K-ATPase in chloride transport
Abstract
The isolated rectal gland of Squalus acanthias was stimulated to secrete chloride against an electrical and a chemical gradient when perfused in vitro by theophylline and/or dibutyryl cyclic AMP. Chloride secretion was depressed by ouabain which inhibits Na-K-ATPase. Thiocyanate and furosemide also inhibited chloride secretion but ethoxzolamide, a carbonic anhydrase inhibitor, did not. Chloride transport was highly dependent on sodium concentration in the perfusate. The intracellular concentration of chloride averaged 70-80 meq/liter in intact glands, exceeding the level expected at electrochemical equilibrium and suggesting active transport of chloride into the cell. These features suggest a tentative hypothesis for chloride secretion by the rectal gland in which the uphill transport of chloride into the cytoplasm is coupled through a membrane carrier to the downhill movement of sodium along its electrochemical gradient. The latter is maintained by the Na-K-ATPase pump while chloride is extruded into the duct by electrical forces.
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Citations
Cites
Carbonic anhydrase: chemistry, physiology, and inhibition
Maren, T. H. (1967) · Physiological Reviews · doi:10.1152/physrev.1967.47.4.595 · Cited by 1,889
Coupled transport of sodium and organic solutes.
Schultz, S. G., & Curran, P. F. (1970) · Physiological Reviews · doi:10.1152/physrev.1970.50.4.637 · Cited by 1,172
Rocha, A. S., & Kokko, J. P. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107223 · Cited by 429
Ion transport by rabbit colon: I. Active and passive components
Frizzell, R. A., Koch, M. J., & Schultz, S. G. (1976) · The Journal of Membrane Biology · doi:10.1007/bf01869142 · Cited by 331
Ernst, S. A. (1972) · Journal of Histochemistry & Cytochemistry · doi:10.1177/20.1.23 · Cited by 273
Sodium chloride transport by rabbit gallbladder. Direct evidence for a coupled NaCl influx process.
Frizzell, R. A., Dugas, M. C., & Schultz, S. (1975) · The Journal of General Physiology · doi:10.1085/jgp.65.6.769 · Cited by 196
Chloride in the squid giant axon
Keynes, R. D. (1963) · The Journal of Physiology · doi:10.1113/jphysiol.1963.sp007289 · Cited by 172
Active transport of chloride in frog cornea
Zadunaisky, J. (1966) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1966.211.2.506 · Cited by 156
Intestinal conductance and permselectivity changes with theophylline and choleragen
Powell, D. W. (1974) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1974.227.6.1436 · Cited by 77
Cited by
Burnett, K. G., Bain, L. J., Baldwin, W. S., Callard, G. V., Cohen, S., Di Giulio, R. T., Evans, D. H., Gómez-Chiarri, M., Hahn, M. E., Hoover, C. A., et al. (2007) · Comparative Biochemistry and Physiology Part D: Genomics and Proteomics · doi:10.1016/j.cbd.2007.09.001 · Cited by 288
Quinton, P. M. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00581513 · Cited by 65
Bovell, D. L., Clunes, M. T., Roussa, E., Burry, J., & Elder, H. Y. (2000) · The Histochemical Journal · doi:10.1023/a:1004087120735 · Cited by 12
Metadata
- Authors
- Silva, P., Stoff, J., Field, M., Fine, L., Forrest, J. N., & Epstein, F. H.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 1977-10-01
- Volume
- 233
- Issue
- 4
- Pages
- F298-F306
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2338399243
- Cited by
- 331
- References
- 9
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mechanism of active chloride secretion by shark rectal gland: role of Na-K-ATPase in chloride transport. https://app.cochat.ai/papers/10.1152/ajprenal.1977.233.4.f298
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- Silva, P., Stoff, J., Field, M., Fine, L., Forrest, J. N., & Epstein, F. H. (1977). Mechanism of active chloride secretion by shark rectal gland: role of Na-K-ATPase in chloride transport. American Journal of Physiology-Renal Physiology. https://doi.org/10.1152/ajprenal.1977.233.4.f298
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
