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Amiloride inhibition of the Na+-H+ exchanger in renal microvillus membrane vesicles
Abstract
We examined the effect of amiloride on Na+-H+ exchange in rabbit renal cortical microvillus membrane vesicles. Amiloride inhibited both the uphill Na+ accumulation induced by imposition of a transmembrane Hin+ greater than Hout+ gradient and the uphill H+ efflux induced by imposition of a Naout+ greater than Nain+ gradient. The inhibitory effect of amiloride on Na+ influx was rapidly reversible and fully competitive (Ki 3.0 X 10(-5) M amiloride, KT 6.3 mM Na+). In addition, amiloride inhibited the efflux of Na+ from vesicles preloaded with Na+. However, the diuretic did not inhibit such other Na+-coupled transport processes as Na+-glucose ad Na+-alanine cotransport. These findings suggest that amiloride is a reversible, selective, competitive inhibitor for the Na+ site of the renal microvillus membrane Na+-H+ exchanger. Amiloride may, therefore, be useful as an experimental tool for investigating the role of Na+-H+ exchange in mediating proximal tubular acidification.
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Cited by
The Role of Na+ and K+ Transporters in Salt Stress Adaptation in Glycophytes
Assaha, D. V. M., Ueda, A., Saneoka, H., Al-Yahyai, R., & Yaish, M. W. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00509 · Cited by 914
Bassil, E., Coku, A., & Blumwald, E. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/ers250 · Cited by 310
The Physiologic Basis of Diuretic Synergism: Its Role in Treating Diuretic Resistance
Ellison, D. H. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-10-886 · Cited by 255
Schlatter, E., Greger, R., & Weidtke, C. (1983) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/bf00587857 · Cited by 254
Traditional and emerging roles for the SLC9 na+/H+ exchangers
Fuster, D. G., & Alexander, R. T. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1408-8 · Cited by 159
Metadata
- Authors
- Kinsella, J. L., & Aronson, P. S.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 1981-10-01
- Volume
- 241
- Issue
- 4
- Pages
- F374-F379
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2396102518
- Cited by
- 188
- References
- 0
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kinsella, J. L., & Aronson, P. S. (1981). Amiloride inhibition of the Na+-H+ exchanger in renal microvillus membrane vesicles. American Journal of Physiology-Renal Physiology. https://doi.org/10.1152/ajprenal.1981.241.4.f374
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