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Characterization of a new model for the study of pressure-natriuresis in the rat
Abstract
The acute relationships between the urinary excretion of sodium and water and renal perfusion pressure were characterized in the rat using a new in vivo model of pressure diuresis. Neural and hormonal influences on the kidney were held constant by denervating the kidney and by maintaining fixed high plasma levels of vasopressin, aldosterone, corticosterone, and norepinephrine levels by intravenous infusion. Renal perfusion pressure (RPP) was varied above and below control using specially designed aortic clamps. Increasing RPP within the autoregulatory range from 90 to 160 mmHg produced 5- to 20-fold increases in urine flow and sodium excretion with no detectable changes in glomerular filtration rate, renal blood flow, or peritubular capillary pressure. The slope of the line relating urine flow and RPP averaged 2 microliter X min-1 X kidney-1 X mmHg-1 rise in RPP. If RPP was first lowered to 90 mmHg, urine flow could be doubled by increasing RPP by as little as 5 mmHg. Uninephrectomy 7-12 days before an experiment did not alter the renal pressure diuresis relationship. The presence of intact renal nerves, however, was found to shift the relationship between urine flow and RPP to the right. The magnitude of the response produced by elevations in pressure using this new model of pressure diuresis was greater than when RPP was increased using carotid occlusion or epinephrine infusion as in previous studies. The results indicate that small changes in arterial pressure may have a greater influence on sodium and water excretion than has been previously recognized.
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“The first, of the renal parenchyma and bearing nociceptive receptors, respond to a renal injury signal by projecting to the hypothalamus to increase central sympathetic outflow95–99.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [98]
In the citing paper
“Renal sympathetic denervation shifts the renal pressure-natriuresis curve to the left, promoting urinary sodium excretion and lowering of blood pressure94–98.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [98]
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ResultFunction of renal angiotensin AT2 receptors is not enhanced in Lyon hypertensive rats
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“Roman RJ, Cowley AW Jr. Characterization of a new model for the study of pressure-natriuresis in the rat.”
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ACUTE PRESSURE–NATRIURESIS RELATIONSHIP FOLLOWING WITHDRAWAL OF CHRONIC NORADRENALINE INFUSION
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“Pressure–natriuresis and pressure–glomerular filtration rate (GFR) relationships were then determined for the left kidney under controlled neural and hormonal conditions.(12,13) In brief, rats were adrenalectomized, the left kidney denervated and an intravenous infusion (0.”
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A Mathematical Model of Neurally-Mediated Angiotensin II-Salt Hypertension
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Immunohistochemical Analyses on Albumin and IgG in Acute Hypertensive Mouse Kidneys
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リコンビナント・ヒト・エリスロポエチン(rHuEPO)の麻酔家兎腎血行動態・腎機能へ及ぼす影響
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Effects of Disease on Renal Blood Flow Regulation: Assessing Autoregulation DisruptionPreprint
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Collett, J. A. (2014) · UKnowledge (University of Kentucky)
Metadata
- Authors
- Roman, R. J., & Cowley, A. W.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 1985-02-01
- Volume
- 248
- Issue
- 2
- Pages
- F190-F198
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W1798432044
- Cited by
- 176
- References
- 0
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 1 · 2017: 3 · 2016: 2 · 2015: 13 · 2014: 10 · 2013: 5 · 2012: 2
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-29587-01, R37HL036279)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Nephrology › Renal and Vascular Pathologies
- Keywords
- pressure natriuresis, pressure diuresis, renal perfusion pressure, sodium excretion, water excretion, renal autoregulation, renal denervation, renal nerves, unilateral nephrectomy, urine flow, renal blood flow, glomerular filtration rate, vasopressin, aldosterone, corticosterone, norepinephrine
- MeSH terms
- Animals, Blood Pressure, Capillaries, Diuresis, Glomerular Filtration Rate, Homeostasis, Hormones, Kidney, Male, Natriuresis, Nephrectomy, Perfusion, Physiology, Rats, Inbred Strains, Rats
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