CoChat
Sign Up
Cited by 201Renin-Angiotensin System StudiesPregnancy and preeclampsia studiesOvarian function and disorders

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Systemic and renal hemodynamic changes in the luteal phase of the menstrual cycle mimic early pregnancy

Chapman, Arlene B., Zamudio, Stacy, Woodmansee, Whitney, Merouani, Aicha, Osorio, Fritz, Johnson, Ann, Moore, Lorna G., Dahms, Thomas, Coffin, Carolyn, Abraham, William T., Schrier, Robert W.·1997·American Journal of Physiology-Renal Physiology
DOI 10.1152/ajprenal.1997.273.5.f777
Open this paper in CoChat — free account

Abstract

Blood pressure decreases during early pregnancy in association with a decrease in peripheral vascular resistance and increases in renal plasma flow and glomerular filtration rate. These early changes suggest a potential association with corpora lutea function. To determine whether peripheral vasodilation occurs following ovulation, we studied 16 healthy women in the midfollicular and midluteal phases of the menstrual cycle. A significant decrease in mean arterial pressure in the midluteal phase of the cycle (midfollicular of 81.7 ± 2.0 vs. midluteal of 75.4 ± 2.3 mmHg, P< 0.005) was found in association with a decrease in systemic vascular resistance and an increase in cardiac output. Renal plasma flow and glomerular filtration rate increased. Plasma renin activity and aldosterone concentration increased significantly in the luteal phase accompanied by a decrease in atrial natriuretic peptide concentration. Serum sodium, chloride, and bicarbonate concentrations and osmolarity also declined significantly in the midluteal phase of the menstrual cycle. Urinary adenosine 3′,5′-cyclic monophosphate (cAMP) excretion increased in the luteal compared with the follicular phase, whereas no changes in urinary cGMP or NO 2/NO 3 excretion were found. Thus peripheral vasodilation occurs in the luteal phase of the normal menstrual cycle in association with an increase in renal plasma flow and filtration. Activation of the renin-angiotensin-aldosterone axis is found in the luteal phase of the menstrual cycle. These changes are accompanied by an increase in urinary cAMP excretion indicating potential vasodilating mediators responsible for the observed hemodynamic changes.

Overview

Integrity signals

Registry

Crossref · 10.1152/ajprenal.1997.273.5.f777

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 39 references

Research works printed but not linked: 7

  1. Henrich W. L., 1978, Am. J. Physiol., 235, F46
  2. Longo L. D., 1984, Rev. Perinatal. Med., 5, 35
  3. Magness R. R., 1989, Am. J. Physiol., 256, E536
  4. Paller M. S., 1989, Am. J. Physiol., 257, R866
  5. Sorensen T. K., 1992, Obstet. Gynecol., 79, 661
  6. Taufield A. P., 1988, Clin. Res., 35, 433
  7. Vokes T. J., 1988, Am. J. Physiol., 254, R641

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Chapman, A. B., Zamudio, S., Woodmansee, W., Merouani, A., Osorio, F., Johnson, A., Moore, L. G., Dahms, T., Coffin, C., Abraham, W. T., & Schrier, R. W.
Affiliations
  • University of Colorado Health Sciences Center, Denver, Colorado 80262
  • University of Colorado Denver (US)
ORCID
Venue
American Journal of Physiology-Renal Physiology
Publisher
American Physiological Society
Published
1997-11-01
Volume
273
Issue
5
Pages
F777-F782
ISSN
  • 1522-1466 (ISSN-L)
  • 1931-857X
DOI
10.1152/ajprenal.1997.273.5.f777
OpenAlex
W1819411215
Cited by
201
References
39
Citations by year
2026: 5 · 2025: 6 · 2024: 1 · 2023: 8 · 2022: 11 · 2021: 9 · 2020: 4 · 2019: 12 · 2018: 8 · 2017: 10 · 2016: 6 · 2015: 4 · 2014: 13 · 2013: 11 · 2012: 10
FWCI
2.68
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Renal Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL-14985, P01HL014985)
  • National Center for Research Resources (MO1-RR-00051-3351, M01RR000051, MO1-RR00051)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
luteal phase, menstrual cycle, early pregnancy, peripheral vasodilation, systemic vascular resistance, renal plasma flow, glomerular filtration rate, mean arterial pressure, cardiac output, renin-angiotensin-aldosterone system, plasma renin activity, aldosterone, atrial natriuretic peptide, urinary cyclic AMP, nitric oxide, corpus luteum, osmolarity
MeSH terms
Cyclic AMP, Adult, Aldosterone, Bicarbonates, Blood Pressure, Blood Volume, Cardiac Output, Chlorides, Female, Follicular Phase, Glomerular Filtration Rate, Cyclic GMP, Heart Rate, Hemodynamics, Humans, Luteal Phase, Atrial Natriuretic Factor, Nitrates, Nitrites, Norepinephrine, Pregnancy, Reference Values, Regional Blood Flow, Renal Circulation, Renin, Renin-Angiotensin System, Sodium, Vascular Resistance, Vasodilation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review