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Ventilatory response to sustained hypoxia in normal adults
Abstract
We examined the ventilatory response to moderate (arterial O2 saturation 80%), sustained, isocapnic hypoxia in 20 young adults. During 25 min of hypoxia, inspiratory minute ventilation (VI) showed an initial brisk increase but then declined to a level intermediate between the initial increase and resting room air VI. The intermediate level of VI was a plateau that did not change significantly when hypoxia was extended up to 1 h. The relation between the amount of initial increase and subsequent decrease in ventilation during constant hypoxia was not random; the magnitude of the eventual decline correlated confidently with the degree of initial hyperventilation. Evaluation of breathing pattern revealed that during constant hypoxia there was little alteration in respiratory timing and that the changes in VI were related to significant alterations in tidal volume and mean inspiratory flow (VT/TI). None of the changes was reproduced during a sham control protocol, in which room air was substituted for the period of low fractional concentration of inspired O2. We conclude that ventilatory response to hypoxia in adults is not sustained; it exhibits some biphasic features similar to the neonatal hypoxic response.
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“Sustained hyperoxia (>60% oxygen) normally results in pulmonary and ocular toxicity due to oxidative damage to endothelial and epithelial cells.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [201]
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“However, long‐term respiratory hyperoxia may have adverse effects on multiple organ systems exposed to O2 > 60%.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [201]
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The pathophysiology of ‘happy’ hypoxemia in COVID-19
Dhont, S., Derom, E., Braeckel, E. V., Depuydt, P. O., & Lambrecht, B. N. (2020) · Respiratory Research · doi:10.1186/s12931-020-01462-5 · Cited by 563
“In healthy subjects, the respiratory drive shifts minimally in mild hypoxemia (PaO2 60–65mmHg), such as resulting from stays at high altitude or experimental hypoxic chambers [11, 26].”
BackgroundThe Ventilatory Response to Hypoxia in Mammals: Mechanisms, Measurement, and Analysis
Teppema, L. J., & Dahan, A. (2010) · Physiological Reviews · doi:10.1152/physrev.00012.2009 · Cited by 395
Exposure to hypoxia produces long-lasting sympathetic activation in humans
Xie, A., Skatrud, J. B., Puleo, D. S., & Morgan, B. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.4.1555 · Cited by 306
“This “roll-off” phenomenon for V̇E, which has been described by previous investigators (3, 22, 44), was not accompanied by a parallel decrease in sympathetic activity.”
Invited Review: Physiological and pathophysiological responses to intermittent hypoxia
Neubauer, J. A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.4.1593 · Cited by 306
Respiratory Drive in Critically Ill Patients. Pathophysiology and Clinical Implications
Vaporidi, K., Akoumianaki, E., Telías, I., Goligher, E. C., Brochard, L. J., & Georgopoulos, D. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201903-0596so · Cited by 273
Metadata
- Authors
- Easton, P. A., Slykerman, L. J., & Anthonisen, N. R.
- ORCID
- Easton, P. A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1986-09-01
- Volume
- 61
- Issue
- 3
- Pages
- 906-911
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1950707731
- Cited by
- 278
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 10 · 2021: 13 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- hypoxic ventilatory response, sustained hypoxia, isocapnic hypoxia, hyperventilation, tidal volume, inspiratory flow, respiratory timing, arterial oxygen saturation
- MeSH terms
- Adult, Hypoxia, Female, Humans, Inspiratory Capacity, Male, Respiration, Respiratory System, Tidal Volume, Time Factors
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