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Quantification of adult cerebral hemodynamics by near-infrared spectroscopy
Abstract
Near-infrared spectroscopy was used to measure global cerebral blood flow and volume in 10 healthy adult volunteers. High- and low-cerebral blood flow compartments were detected with mean flows for all 10 subjects of 59 +/- 21 (SD) and 11 +/- 4 ml.100 g-1.min-1, respectively. The mean cerebral blood volume of the group was 2.85 +/- 0.97 ml/100 g. Analysis of spontaneous changes in the cerebral concentrations of oxyhemoglobin and deoxyhemoglobin demonstrated strong correlations between respiratory rate and the oscillation frequency of cerebral oxyhemoglobin concentration (r = 0.99) and arterial oxygen saturation (SaO2) (r = 0.99). An estimate of the mean cerebral oxygen saturation for all subjects averaged 59.4 +/- 12.4% when their mean SaO2 was 91.8 +/- 2.4% (equivalent to 67.6 +/- 13.8% at a normoxic SaO2 of 98%). These results demonstrate that near-infrared spectroscopy can be used as a noninvasive bedside technique for both qualitative and quantitative evaluation of cerebral hemodynamics and oxygenation in adults.
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Cited by
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Cerebral blood flow and metabolism during exercise: implications for fatigue
Secher, N. H., Seifert, T., & Van Lieshout, J. J. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00853.2007 · Cited by 344
Fantini, S., Hueber, D., Franceschini, M. A., Gratton, E., Rosenfeld, W., Stubblefield, P. G., Maulik, D., & Stankovic, M. R. (1999) · Physics in Medicine and Biology · doi:10.1088/0031-9155/44/6/308 · Cited by 277
Mehagnoul‐Schipper, D. J., van der Kallen, B. F. W., Colier, W. N. J. M., van der Sluijs, M. C., van Erning, L. J. T. O., Thijssen, H. O. M., Oeseburg, B., Hoefnagels, W. H. L., & Jansen, R. W. M. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10026 · Cited by 264
Homma, S., Fukunaga, T., & Kagaya, A. (1996) · Journal of Biomedical Optics · doi:10.1117/12.252417 · Cited by 123
Metadata
- Authors
- Elwell, C. E., Cope, M., Edwards, A. D., Wyatt, J. S., Delpy, D. T., & Reynolds, E. O.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1994-12-01
- Volume
- 77
- Issue
- 6
- Pages
- 2753-2760
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1596077691
- Cited by
- 219
- References
- 0
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Elwell, C. E., Cope, M., Edwards, A. D., Wyatt, J. S., Delpy, D. T., & Reynolds, E. O. (1994). Quantification of adult cerebral hemodynamics by near-infrared spectroscopy. Journal of Applied Physiology. https://doi.org/10.1152/jappl.1994.77.6.2753
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