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Cited by 134Cardiovascular Syncope and Autonomic DisordersRenin-Angiotensin System StudiesBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Effect of standing on neurohumoral responses and plasma volume in healthy subjects

Jacob, Giris, Ertl, Andrew C., Shannon, John R., Furlan, Raffaello, Robertson, Rose Marie, Robertson, David·1998·Journal of Applied Physiology
DOI 10.1152/jappl.1998.84.3.914
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Abstract

Upright posture leads to rapid pooling of blood in the lower extremities and shifts plasma fluid into surrounding tissues. This results in a decrease in plasma volume (PV) and in hemoconcentration. There has been no integrative evaluation of concomitant neurohumoral and PV shifts with upright posture in normal subjects. We studied 10 healthy subjects after 3 days of stable Na+and K+intake. PV was assessed by the Evans blue dye method and by changes in hematocrit. Norepinephrine (NE), NE spillover, epinephrine (Epi), vasopressin, plasma renin activity, aldosterone, osmolarity, and kidney response expressed by urine osmolality and by Na+and K+excretion of the subjects in the supine and standing postures were all measured. We found that PV fell by 13% (375 ± 35 ml plasma) over ∼14 min, after which time it remained relatively stable. There was a concomitant decrease in systolic blood pressure and an increase in heart rate that peaked at the time of maximal decrease in PV. Plasma Epi and NE increased rapidly to this point. Epi approached baseline by 20 min of standing. NE spillover increased 80% and clearance decreased 30% with 30 min of standing. The increase in plasma renin activity correlated with an increase in aldosterone. Vasopressin increased progressively, but there was no change in plasma osmolarity. The kidney response showed a significant decrease in Na+and an increase in K+excretion with upright posture. We conclude that a cascade of neurohumoral events occurs with upright posture, some of which particularly coincide with the decrease in PV. Plasma Epi levels may contribute to the increment in heart rate with maintained upright posture.

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Crossref · 10.1152/jappl.1998.84.3.914

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Research works printed but not linked: 4

  1. Allen T. H., 1975, Metabolism, 5, 328
  2. Borst C., 1982, Am. J. Physiol., 243, H676
  3. Campbell T. J., 1958, J. Lab. Clin. Med., 52, 768
  4. Fujii Y., 1990, Am. J. Physiol., 259, F40

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Metadata

Authors
Jacob, G., Ertl, A. C., Shannon, J. R., Furlan, R., Robertson, R. M., & Robertson, D.
Affiliations
Vanderbilt University (US)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1998-03-01
Volume
84
Issue
3
Pages
914-921
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1998.84.3.914
OpenAlex
W2157236879
Cited by
134
References
37
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 3 · 2012: 5
FWCI
4.81
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5u01ns033460-03)
  • National Heart, Lung, and Blood Institute (P01HL056693, P01 HL-56693)
  • National Institute of Neurological Disorders and Stroke (NS 33460)
  • National Center for Research Resources (RR00095)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
standing posture, upright posture, plasma volume, neurohumoral response, norepinephrine spillover, epinephrine, vasopressin, plasma renin activity, aldosterone, hemoconcentration, blood pressure, heart rate, sodium excretion, potassium excretion, urine osmolality, plasma osmolarity, renal response
MeSH terms
Adult, Aldosterone, Arginine Vasopressin, Blood Pressure, Blood Volume, Catecholamines, Diet, Female, Heart Rate, Humans, Kidney, Male, Middle Aged, Plasma Volume, Posture, Reference Values, Renin, Supine Position, Neurotransmitter Agents

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