The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells
Abstract
Airway remodeling with smooth muscle cell (SMC) hyperplasia is a feature of chronic asthma. We investigated the potential for tryptase, the major secretory product of human mast cells, to act as a growth factor for human airway SMCs. Because this serine protease can activate proteinase-activated receptor-2 (PAR-2), we also examined the actions of SLIGKV, a peptide agonist of PAR-2. Incubation with lung tryptase provoked a twofold increase in [3 H]thymidine incorporation; a similar increase in cell numbers was found when we used the MTS assay. The effect was catalytic site dependent, being abolished by the protease inhibitors leupeptin and benzamidine and by heat inactivation of the enzyme. Tryptase-induced DNA synthesis was inhibited by preincubation of the cells with pertussis toxin, calphostin C, or genistein. Transduction mechanisms are thus likely to involve a pertussis toxin-sensitive G protein, protein kinase C, and tyrosine kinase. SLIGKV elicited a response on SMCs similar to that of tryptase. Tryptase could provide an important stimulus for SMC proliferation in asthmatic airways, by acting on PAR-2.
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Citations
Cites
Mast cell tryptase is a mitogen for cultured fibroblasts
Ruoss, S. J., Hartmann, T., & Caughey, G. H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115330 · Cited by 390
Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts
Cairns, J. A., & Walls, A. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119290 · Cited by 318
Self-citation
Cited by
Protease-Activated Receptors: Contribution to Physiology and Disease
OSSOVSKAYA, V. S., & BUNNETT, N. W. (2004) · Physiological Reviews · doi:10.1152/physrev.00028.2003 · Cited by 1,078
MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances
Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. M., & Tsai, M. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141025 · Cited by 1,017
The role of the mast cell in the pathophysiology of asthma
Bradding, P., Walls, A. F., & Holgate, S. T. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.02.039 · Cited by 573
Self-citationAirway remodeling in asthma: what really matters
Fehrenbach, H., Wagner, C., & Wegmann, M. (2017) · Cell and Tissue Research · doi:10.1007/s00441-016-2566-8 · Cited by 406
Airway remodeling contributes to the progressive loss of lung function in asthma: An overview
Pascual, R. M., & Peters, S. P. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.07.011 · Cited by 364
Metadata
- Authors
- Berger, P., Perng, D.-W., Thabrew, H., Compton, S. J., Cairns, J. A., McEuen, A. R., Marthan, R., Tunon De Lara, J.-M., & Walls, A. F.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2001-09-01
- Volume
- 91
- Issue
- 3
- Pages
- 1372-1379
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W59008486
- Cited by
- 173
- References
- 2
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Berger, P., Perng, D.-W., Thabrew, H., Compton, S. J., Cairns, J. A., McEuen, A. R., Marthan, R., Tunon De Lara, J.-M., & Walls, A. F. (2001). Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells. Journal of Applied Physiology. https://doi.org/10.1152/jappl.2001.91.3.1372
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