Variability in vastus lateralis fiber type distribution, fiber size, and myonuclear content along and between the legs
Open accessAbstract
This study provides a comprehensive analysis of the variability of key human skeletal muscle fiber characteristics in multiple sites along and between the musculus vastus lateralis of healthy and active individuals. We found a notable but nonsystematic variability in fiber type and size, whereas myonuclear content was distinctively less variable, and the prevalence of type IIX fibers was random and very low. These data are important to consider when designing and interpreting studies including musculus vastus lateralis biopsies.
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The variation in observed prepost correlations may reflect small differences in biopsy site, tissue handling and weighing, muscle fiber-type composition, and/or individual differences in substrate utilization.
“This variation may re fl ect small differences in biopsy site, tissue handling and weighing, muscle fi ber-type composition, and/or individual differences in substrate utilization (81 -83).”
From Carbohydrate ingestion during prolonged exercise and net skeletal muscle glycogen utilization: A meta-analysis. (2026) · cites this paper as [81]
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References 65 · Cited by 87
- Authors
- Horwath, O., Envall, H., Röja, J., Emanuelsson, E. B., Sanz, G., Ekblom, B., Apró, W., & Moberg, M.
- Affiliations
- Swedish School of Sport and Health Sciences (SE)
- Karolinska Institutet (SE)
- Department of Physiology, Nutrition and Biomechanics, Åstrand Laboratory, Swedish School of Sport and Health Sciences, Stockholm, Sweden
- Corresponding author
- Moberg, Marcus
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2021-07-01
- Volume
- 131
- Issue
- 1
- Pages
- 158-173
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W3162007925
- Cited by
- 87
- References
- 65
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 20 · 2023: 18 · 2022: 15 · 2021: 2
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- green
- urn.kb.se
- Licence
- other-oa
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- Funders
- Swedish National Centre for Research in Sports (D2017-0012, D2019-0050, 2017-0038, 2019-0061)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- vastus lateralis, fiber diameter, type IIx fibers, interindividual variability, muscle biopsy, human skeletal muscle
- MeSH terms
- Humans, Leg, Muscle, Skeletal, Muscle Fibers, Skeletal, Myosin Heavy Chains, Quadriceps Muscle
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