Pulmonary transit of agitated contrast is associated with enhanced pulmonary vascular reserve and right ventricular function during exercise
Abstract
Pulmonary transit of agitated contrast (PTAC) occurs to variable extents during exercise. We tested the hypothesis that the onset of PTAC signifies flow through larger-caliber vessels, resulting in improved pulmonary vascular reserve during exercise. Forty athletes and fifteen nonathletes performed maximal exercise with continuous echocardiographic Doppler measures [cardiac output (CO), pulmonary artery systolic pressure (PASP), and myocardial velocities] and invasive blood pressure (BP). Arterial gases and B-type natriuretic peptide (BNP) were measured at baseline and peak exercise. Pulmonary vascular resistance (PVR) was determined as the regression of PASP/CO and was compared according to athletic and PTAC status. At peak exercise, athletes had greater CO (16.0 ± 2.9 vs. 12.4 ± 3.2 l/min, P < 0.001) and higher PASP (60.8 ± 12.6 vs. 47.0 ± 6.5 mmHg, P < 0.001), but PVR was similar to nonathletes (P = 0.71). High PTAC (defined by contrast filling of the left ventricle) occurred in a similar proportion of athletes and nonathletes (18/40 vs. 10/15, P = 0.35) and was associated with higher peak-exercise CO (16.1 ± 3.4 vs. 13.9 ± 2.9 l/min, P = 0.010), lower PASP (52.3 ± 9.8 vs. 62.6 ± 13.7 mmHg, P = 0.003), and 37% lower PVR (P < 0.0001) relative to low PTAC. Right ventricular (RV) myocardial velocities increased more and BNP increased less in high vs. low PTAC subjects. On multivariate analysis, maximal oxygen consumption (VO(2max)) (P = 0.009) and maximal exercise output (P =…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
B-type natriuretic peptide release during intense exercise is associated with greater relative increases in right ventricular systolic pressures, but not left ventricular pressures.
“We have previously demonstrated that BNP release during intense exercise is associated with greater relative increases in RV systolic pressures, but not LV pressures.30”
From Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes (2012) · cites this paper as [30]
Trained athletes during intense exercise demonstrate considerable increases in pulmonary pressures.
“The considerable increases in pulmonary pressures demonstrated in trained athletes during intense exercise 29,30,34 suggest a similar physiological stress, albeit only transient.”
From Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes (2012) · cites this paper as [30]
The citation lists haven’t been fetched yet
References 51 · Cited by 168
- Authors
- La Gerche, A., MacIsaac, A. I., Burns, A. T., Mooney, D. J., Inder, W. J., Voigt, J.-U., Heidbüchel, H., & Prior, D. L.
- Affiliations
- Departments of 1Medicine and of
- The University of Melbourne (AU)
- KU Leuven (BE)
- ORCID
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2010-11
- Volume
- 109
- Issue
- 5
- Pages
- 1307-1317
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2145654497
- Cited by
- 168
- References
- 51
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 11 · 2018: 6 · 2017: 18 · 2016: 11 · 2015: 17 · 2014: 16 · 2013: 15 · 2012: 19
- FWCI
- 10.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Keywords
- pulmonary vascular resistance, right ventricular function, exercise hemodynamics, athletes, cardiac output, pulmonary artery systolic pressure, brain natriuretic peptide, VO2max, pulmonary artery catheterization
- MeSH terms
- Adaptation, Physiological, Adult, Blood Pressure, Cardiac Output, Contrast Media, Gelatin, Heart Ventricles, Hemodynamics, Humans, Lung, Myocardial Contraction, Oxygen, Oxygen Consumption, Partial Pressure, Physical Endurance, Predictive Value of Tests, Pulmonary Circulation, Succinates, Vascular Resistance, Echocardiography, Doppler, Biomarkers, Exercise, Ventricular Function, Right, Echocardiography, Doppler, Color, Echocardiography, Doppler, Pulsed, Natriuretic Peptide, Brain, Microbubbles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
