Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism
Open accessAbstract
Lactate sensing and signaling is a relatively new and rapidly changing field. As a physiological signal lactate works both independently and in concert with other signals. Lactate operates via covalent binding and canonical signaling, redox change, and lactylation of DNA. Lactate can also serve as an element of feedback loops in cardiopulmonary regulation. From conception through aging lactate is not the only a myokine or exerkine, but it certainly deserves consideration as a physiological signal.
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References 252 · Cited by 171
- Authors
- Brooks, G. A., Osmond, A. D., Arevalo, J. A., Duong, J. J., Curl, C. C., Moreno-Santillan, D. D., & Leija, R. G.
- Affiliations
- University of California, Berkeley (US)
- Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States
- Corresponding author
- Brooks, George A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2023-03-01
- Volume
- 134
- Issue
- 3
- Pages
- 529-548
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- PMC
- PMC9970662
- OpenAlex
- W4315754627
- Cited by
- 171
- References
- 252
- Citations by year
- 2026: 50 · 2025: 61 · 2024: 36 · 2023: 23 · 2022: 1
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Journal of Applied Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of California Berkeley | Center for Research and Education on Aging (001)
- HHS | NIH | National Institute on Aging (R01AG059715)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- lactate, myokines, exerkines, lactate signaling, lactate sensing, lactylation, redox signaling, feedback loops, aging, exercise metabolism, physiological signals
- MeSH terms
- Humans, Muscles, Oxidation-Reduction, Exercise, Lactic Acid, Carcinogenesis
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