Two weeks of single-leg immobilization alters intramyocellular lipid storage characteristics in healthy, young women
Abstract
We report that the subcellular storage location of IMCL is altered by limb immobilization, highlighting the need to evaluate IMCL storage location when assessing the effects of disuse on IMCL content. We also found that AKT content increased during immobilization in our female population, contrary to studies in males finding that AKT decreases during disuse, highlighting that men and women may respond differently to disuse and the necessity to include women in all research.
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Muscle disuse leads to a shift away from lipid toward carbohydrate oxidation similar to that seen with old age, potentially compounding deficits in metabolic flexibility and leading to further intramyocellular lipid accumulation.
“Evidence suggests that muscle disuse leads to a shift away from lipid toward carbohydrate oxidation has been shown with muscle disuse [62, 72, 82] similar to that seen with old age, potentially compounding deficits in metabolic flexibility and leading to further IMCL accumulation.”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [72]
With imposed muscle disuse, normal resting lipid oxidation is disrupted and these conditions are associated with increased intramyocellular lipids.
“With imposed muscle disuse (e.g., bedrest, immobilization), normal resting lipid oxidation is disrupted and these conditions are also associated with increased IMCL [62, 72, 82].”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [72]
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References 58 · Cited by 6
- Authors
- Black, M. N., Wilkinson, J. A., Webb, E. K., Kamal, M., Bahniwal, R., McGlory, C., Phillips, S. M., & Devries, M. C.
- Affiliations
- University of Waterloo (CA)
- McMaster University (CA)
- Corresponding author
- Devries, Michaela C.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2021-04-01
- Volume
- 130
- Issue
- 4
- Pages
- 1247-1258
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W3129771908
- Cited by
- 6
- References
- 58
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NSERC graduate scholarship
- Canadian Institutes of Health Research
- NSERC Discovery Grant
- Diabetes Canada Postdoctoral Fellowship
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- intramyocellular lipid, limb immobilization, disuse, Akt, sex differences, skeletal muscle, young women
- MeSH terms
- Adult, Female, Humans, Immobilization, Insulin Resistance, Leg, Lipids, Male, Muscle, Skeletal, Lipid Metabolism, Glucose Transporter Type 4, Quadriceps Muscle, Young Adult
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