Cited by 612Muscle Physiology and DisordersExercise and Physiological ResponsesMuscle metabolism and nutrition

The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.

IL-6-induced skeletal muscle atrophy

Open access

Haddad, F., Zaldivar, F., Cooper, D. M., Adams, G. R.·2005·Journal of Applied Physiology

DOI 10.1152/japplphysiol.01026.2004

Open this paper in CoChat — free account

Abstract

Chronic, low-level elevation of circulating interleukin (IL)-6 is observed in disease states as well as in many outwardly healthy elderly individuals. Increased plasma IL-6 is also observed after intense, prolonged exercise. In the context of skeletal muscle, IL-6 has variously been reported to regulate carbohydrate and lipid metabolism, increase satellite cell proliferation, or cause muscle wasting. In the present study, we used a rodent local infusion model to deliver modest levels of IL-6, comparable to that present after exercise or with chronic low-level inflammation in the elderly, directly into a single target muscle in vivo. The aim of this study was to examine the direct effects of IL-6 on skeletal muscle in the absence of systemic changes in this cytokine. Data included cellular and molecular markers of cytokine and growth factor signaling (phosphorylation and mRNA content) as well as measurements to detect muscle atrophy. IL-6 infusion resulted in muscle atrophy characterized by a preferential loss of myofibrillar protein (−17%). IL-6 induced a decrease in the phosphorylation of ribosomal S6 kinase (−60%) and STAT5 (−33%), whereas that of STAT3 was increased approximately twofold. The changes seen in the IL-6-infused muscles suggest alterations in the balance of growth factor-related signaling in favor of a more catabolic profile. This suggests that downregulation of growth factor-mediated intracellular signaling may be a mechanism contributing to the development of muscle atrophy induced by elevated IL-6.

Integrity signals

Registry

Crossref · 10.1152/japplphysiol.01026.2004

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION
Gornall, A. G., Bardawill, C. J., & David, M. M. (1949) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57021-6 · Cited by 16,164
A simple, rapid, and sensitive DNA assay procedure
Labarca, C. G., & Paigen, K. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90165-7 · Cited by 4,870
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272
A good practice guide to the administration of substances and removal of blood, including routes and volumes
Diehl, K., Hull, R., Morton, D. B., Pfister, R., Rabemampianina, Y., Smith, D. W., Vidal, J., & Vorstenbosch, C. V. D. (2001) · Journal of Applied Toxicology · doi:10.1002/jat.727 · Cited by 1,570
Pro‐ and anti‐inflammatory cytokine balance in strenuous exercise in humans
Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.287ad.x · Cited by 1,014
Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875
Suppressors of cytokine signalling (SOCS) in the immune system
Alexander, W. S. (2002) · Nature reviews. Immunology · doi:10.1038/nri818 · Cited by 645
Searching for the exercise factor: is IL-6 a candidate?
Pedersen (2003) · Journal of Muscle Research and Cell Motility · doi:10.1023/a:1026070911202 · Cited by 564
Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.
De Benedetti, F., Alonzi, T., Moretta, A., Lazzaro, D., Costa, P., Poli, V, Martini, A., Ciliberto, G., & Fattori, E. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119207 · Cited by 529

Flagged first, then by citations

Show all 60 references

1 of the 60 references couldn’t be matched to a known paper.

Sorted by citations

Items 401–500 of 609

Molecular Changes in Sub-lesional Muscle Following Acute Phase of Spinal Cord Injury
Thakore, N. P., Samantaray, S., Park, S., Nozaki, K., Smith, J. A., Cox, A., Krause, J. S., & Banik, N. L. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1696-9 · Cited by 11
Restoration of pharyngeal dilator muscle force in dystrophin‐deficient (mdx) mice following co‐treatment with neutralizing interleukin‐6 receptor antibodies and urocortin 2
Burns, D. P., Rowland, J., Canavan, L., Murphy, K. H., Brannock, M., O’Malley, D., O’Halloran, K. D., & Edge, D. (2017) · Experimental Physiology · doi:10.1113/ep086232 · Cited by 11
Muscle‐specific differences in expression and phosphorylation of the Janus kinase 2/Signal Transducer and Activator of Transcription 3 following long‐term mechanical ventilation and immobilization in rats
Salah, H. A., Fury, W., Gromada, J., Bai, Y., Tchkonia, T., Kirkland, J. L., & Larsson, L. (2017) · Acta Physiologica · doi:10.1111/apha.12980 · Cited by 11
Skeletal Muscle as an Auto-, Para- and Endocrine Organ: The Role of Myokines in Muscle Metabolism and Other Metabolic Organs
Horváth, L., Pekár, M., Švagera, Z., Horká, V., Mráz, M., & Bužga, M. (2025) · Physiological Research · doi:10.33549/physiolres.935751 · Cited by 14
A comprehensive review on the risks assessment and treatment options for Sarcopenia in people with diabetes
Johri, N., Vengat, M., Kumar, D., Nagar, P., John, D., Dutta, S., & Mittal, P. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01262-w · Cited by 12
Improvement in muscle strength after an anterior cruciate ligament injury corresponds with a decrease in serum cytokines
Barker, T., Henriksen, V. T., Rogers, V. E., & Trawick, R. H. (2015) · Cytokine · doi:10.1016/j.cyto.2015.01.036 · Cited by 10
Correlations between the levels of acute infection markers and serum albumin in elderly patients with hip fracture
Shi, H., Na, Q., Zhang, X., & Jiang, X. (2016) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0585-7 · Cited by 11
Chronic Resistance Exercise Improves Functioning and Reduces Toll-Like Receptor Signaling in Elderly Patients With Postoperative Deconditioning
Yan-bing, W., Xiaohai, H., & Chen, L. (2020) · Journal of Manipulative and Physiological Therapeutics · doi:10.1016/j.jmpt.2020.01.001 · Cited by 10
Ganoderma microsporum immunomodulatory protein, GMI, promotes C2C12 myoblast differentiation in vitro via upregulation of Tid1 and STAT3 acetylation
Teo, W., Lo, J., Fann, Y., Huang, C., & Huang, T.-F. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244791 · Cited by 10
Aterosclerosis subclínica, un predictor de limitación funcional al año en ancianos con alto nivel funcional: estudio Albacete
Abizanda, P., Mellinas, G. P., Martín-Sebastiá, E., Moragón, L. C., Jiménez, E. L., & Martínez‐Sánchez, E. (2010) · Revista Española de Geriatría y Gerontología · doi:10.1016/j.regg.2009.09.005 · Cited by 10
Experimental Periodontitis in the Potentialization of the Effects of Immobilism in the Skeletal Striated Muscle
Leite, M. A., de Mattia, T. M., Kakihata, C. M. M., Bortolini, B. M., Rodrigues, P. H. D. C., Bertolini, G. R. F., Brancalhão, R. M. C., Ribeiro, L. D. F. C., Nassar, C. A., & Nassar, P. O. (2017) · Inflammation · doi:10.1007/s10753-017-0640-3 · Cited by 10
Strategic Approaches in Generation of Robust Microphysiological 3D Musculoskeletal Tissue System
Kim, J.-S., Kim, I. U., Lee, Z. F., Sim, G., & Jeon, J. S. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202410872 · Cited by 10
Cytokine networks in immune-mediated muscle regeneration
Dziki, J. L., Velayutham, M., Hussey, G. S., & Turnquist, H. R. (2018) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2018.03.001 · Cited by 9
Marked skeletal muscle deficits are associated with 6-minute walk distance in paediatric pulmonary hypertension
Avitabile, C. M., Saavedra, S., Sivakumar, N., Goldmuntz, E., Paridon, S. M., & Zemel, B. S. (2021) · Cardiology in the Young · doi:10.1017/s1047951121000342 · Cited by 9
Elevated biomarkers of neural injury in older adults following head-down bed rest: links to cardio-postural deconditioning with spaceflight and aging
Blaber, A. P., Sadeghian, F., Divsalar, D. N., & Scarisbrick, I. A. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1208273 · Cited by 9
The Influence and Delivery of Cytokines and their Mediating Effect on Muscle Satellite Cells
Nederveen, J. P., Joanisse, S., Snijders, T., & Parise, G. (2017) · Current Stem Cell Reports · doi:10.1007/s40778-017-0089-1 · Cited by 10
mRNA expressions of peroxisome proliferator-activated receptor gamma coactivator 1α, tumor necrosis factor-α, and interleukin-6 in paraspinal muscles of patients with lumbar kyphosis: a preliminary study
Kudo, D., Miyakoshi, N., Hongo, M., Kasukawa, Y., Ishikawa, Y., Fujii, M., & Shimada, Y. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s172952 · Cited by 9
Neuregulin-1β modulates myogenesis in septic mouse serum-treated C2C12 myotubes in vitro through PPARγ/NF-κB signaling
Liu, L., Liu, X., Bai, Y., Tang, N., Li, J., Zhang, Y., Wu, J., Wang, X., & Wei, J. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4293-6 · Cited by 9
LPS-Induced Modifications in Macrophage Transcript and Secretion Profiles Are Linked to Muscle Wasting and Glucose Intolerance
Ryu, H., Jeong, H. H., Lee, S., Lee, M., Kim, M., & Lee, B. (2023) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2309.09037 · Cited by 8
Combined Treatment of Metformin and Resveratrol Promotes Myogenesis Through Increased Irisin Release in C2C12 Cells
Seong, E. J., Kim, Y., Su, Z., Kang, H., & Lee, J. H. (2025) · Pharmaceutical Research · doi:10.1007/s11095-025-03834-2 · Cited by 8
β-hydroxy-β-methylbutyrate supplementation mitigates muscle atrophy induced by inactivity and protein deprivation
He, X., Li, Y., Chen, J., Huang, Y., Zhou, Y., Yang, L., & Quan, J. (2025) · Biogerontology · doi:10.1007/s10522-025-10262-7 · Cited by 8
Mechanisms of Exercise in Improving Sarcopenia
Su, M., Shao, Y., Fang, Q., Li, Y., Qiu, F., Che, T., & Zhang, S. (2025) · Comprehensive physiology · doi:10.1002/cph4.70030 · Cited by 9
Unraveling the metabolic pathways between atherosclerosis and sarcopenia
Yu, M., Ge, L., Fu, C., & Zhao, R. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1762825 · Cited by 9
IMPORTANCE OF THE INNATE IMMUNE RESPONSE IN SKELETAL MUSCLE TO SEPSIS-INDUCED ALTERATIONS IN PROTEIN BALANCE
Lang, C. H. (2022) · Shock · doi:10.1097/shk.0000000000002029 · Cited by 8
Old muscle, new tricks: a clinician perspective on sarcopenia and where to next
Schütze, K., Schopp, M., Fairchild, T. J., & Needham, M. (2023) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001185 · Cited by 8
IL-6 Promotes Muscle Atrophy by Increasing Ubiquitin–Proteasome Degradation of Muscle Regeneration Factors After Cerebral Infarction in Rats
Chen, F., Fu, J., & Feng, H. (2025) · NeuroMolecular Medicine · doi:10.1007/s12017-024-08825-x · Cited by 8
Suppressor of Cytokine Signaling, Skeletal Muscle, and Chronic Health Conditions
Spangenburg, E. E. (2007) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3180a02fe6 · Cited by 8
The quasi-parallel lives of satellite cells and atrophying muscle
Biressi, S. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00140 · Cited by 9
Ascorbic Acid Attenuates Multifidus Muscles Injury and Atrophy After Posterior Lumbar Spine Surgery by Suppressing Inflammation and Oxidative Stress in a Rat Model
Tang, P., Zhu, R., Gu, Y. X., Gu, J., Xie, Z., Xu, J., Zhao, X., Huang, K., Wang, J., Jiang, X., et al. (2018) · Spine · doi:10.1097/brs.0000000000002669 · Cited by 8
Toxoplasma gondii Impairs Myogenesis in vitro, With Changes in Myogenic Regulatory Factors, Altered Host Cell Proliferation and Secretory Profile
Vieira, P. D. C., Waghabi, M. C., Beghini, D. G., Predes, D., Abreu, J. G., Mouly, V., Butler-Browne, G. S., Barbosa, H. S., & Adesse, D. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00395 · Cited by 8
Corticotropin releasing factor-overexpressing mouse is a model of chronic stress-induced muscle atrophy
Kang, W., Tong, T., & Park, T. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229048 · Cited by 10
Direct and acute effects of advanced glycation end products on proteostasis in isolated mouse skeletal muscle
Zhao, H., Iyama, R., Kurogi, E., Hayashi, T., & Egawa, T. (2024) · Physiological Reports · doi:10.14814/phy2.16121 · Cited by 8
Post-translational dysregulation of glucose uptake during exhaustive cycling exercise in vastus lateralis muscle of healthy homozygous carriers of the ACE deletion allele
Flück, M., Vaughan, D. A., Rittweger, J., & Giraud, M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.933792 · Cited by 7
Mechanism of muscle atrophy in a normal-weight rat model of type 2 diabetes established by using a soft-pellet diet
Akieda‐Asai, S., Ma, H., Han, W., Nagata, J., Yamaguchi, F., & Date, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-57727-2 · Cited by 7
Protective action of ultrasound-guided electrolysis technique on the muscle damage induced by notexin in rats
Jorda, A., Campos-Campos, J., Aldasoro, C., Campo-Palacio, I., Alvarez-Gamez, K., Blasco, M. C., Aldasoro, M., & Vallés, S. L. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276634 · Cited by 10
Ameliorative Effects of Cumin Extract-Encapsulated Chitosan Nanoparticles on Skeletal Muscle Atrophy and Grip Strength in Streptozotocin-Induced Diabetic Rats
Wu, Y.-C., Su, M.-C., Wu, C.-S., Chen, P.-Y., Chen, I., Lin, F., & Kuo, S. (2023) · Antioxidants · doi:10.3390/antiox13010006 · Cited by 7
Biochemical Interaction Between Muscle and Bone: A Physiological Reality?
Jaspers, R. T., & Bravenboer, N. (2014) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-014-9156-7 · Cited by 7
Polymorphism of The Regulatory Region of the ITGAM Gene (-323G>A) as a Novel Predictor of a Poor Nutritional Status in Head and Neck Cancer Patients Subjected to Intensity-Modulated Radiation Therapy
Mazurek, M., Mlak, R., Homa‐Mlak, I., Powrózek, T., Brzozowska, A., Gołębiowski, P., & Malecka-Massalska, T. J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9124041 · Cited by 7
Association between vitamin D deficiency and exercise capacity in patients with CKD, a cross-sectional analysis
Watson, E. L., Wilkinson, T. J., O’Sullivan, T. F., Baker, L. A., Gould, D. W., Xenophontos, S., Graham-Brown, M. P. M., Major, R., Jenkinson, C., Hewison, M., et al. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105861 · Cited by 7
The impact of N‐acetylcysteine on lactate, biomarkers of oxidative stress, immune response, and muscle damage: A systematic review and meta‐analysis
Sadowski, M., Zawieja, E. E., & Chmurzyńska, A. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70198 · Cited by 11
Ruxolitinib alleviated muscle atrophy in cancer cachexia by inhibiting IL-6/JAK/STAT3 signaling pathway in mice
Li, C., Gu, X., Zhu, Z., Pan, X., Fan, M., Liu, X., & Zhang, X. (2025) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgaf073 · Cited by 6
Role of PPARα in inflammatory response of C2C12 myotubes
Shimizu, Y., Hamada, K., Guo, T., Hasegawa, C., Kuga, Y., Takeda, K., Yagi, T., Koyama, H., Takagi, H., Aotani, D., et al. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149413 · Cited by 6
Methods for diagnosing malnutrition in patients with esophageal cancer, and the association with nutritional and inflammatory indices: A cross‑sectional study
Kong, X., Liu, P., Wang, G., Sun, S., & Li, L. (2025) · Oncology Letters · doi:10.3892/ol.2025.14969 · Cited by 6
Unresolved intramuscular inflammation, not diminished skeletal muscle regenerative capacity, is at the root of rheumatoid cachexia: insights from a rat CIA model
Ollewagen, T., Powrie, Y. S. L., Myburgh, K. H., & Smith, C. (2021) · Physiological Reports · doi:10.14814/phy2.15119 · Cited by 5
Nativity differences in the relationship between handgrip strength and cognitive impairment in older Mexican Americans over 20 years of follow-up
Ventura, J., Downer, B. G., Li, C., & Snih, S. A. (2022) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2022.104903 · Cited by 5
Which vertebral level should be used to calculate sarcopenia in covid-19 patients? A systematic review and meta-analysis
Sumbal, R., Sumbal, A., & Baig, M. M. A. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.04.022 · Cited by 5
Modulation of macrophage transcript and secretion profiles by Sargassum Serratifolium extract is associated with the suppression of muscle atrophy
Ryu, H., Jeong, H. H., Kim, M., Lee, S., Jung, W., & Lee, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-63146-0 · Cited by 5
Leucine and perindopril to improve physical performance in people over 70 years with sarcopenia: the LACE factorial RCT
Witham, M. D., Adamson, S., Avenell, A., Band, M. M., Bashir, T., Donnan, P. T., Casella, G., Hapca, A., Hume, C., Kemp, P. R., et al. (2022) · Efficacy and Mechanism Evaluation · doi:10.3310/llbx6901 · Cited by 5
Mammalian models of pathogen-associated muscle degeneration
Nas, J. S., Galang, T. J., Bacod, A., Cervantes, C. A., Estrilles, J. I., Esguera, R., Milleza, R. M., Servino, P. A., & Lacorte, L. H. (2022) · Exploratory Animal and Medical Research · doi:10.52635/eamr/12.2.134-148 · Cited by 5
The Association of Carbohydrate Antigen (CA) 19-9 Levels and Low Skeletal Muscle Mass in Healthy Adults
Lee, J. H., Kim, D., Lee, M. Y., Lim, H.-S., Kwon, M., Lee, Y., Yoon, K. J., & Park, C. (2023) · Nutrients · doi:10.3390/nu15153394 · Cited by 5
Interleukin-6: Unravelling its role in sarcopenia pathogenesis and exploring therapeutic avenues
Assyov, Y. S., Ganeva, I., Ikonomov, S., Nedeva, I., Velikov, T., Kamenov, Z. A., & Velikova, T. V. (2023) · Pharmacia · doi:10.3897/pharmacia.70.e115762 · Cited by 5
Daily Eicosapentaenoic Acid Infusion in IUGR Fetal Lambs Reduced Systemic Inflammation, Increased Muscle ADRβ2 Content, and Improved Myoblast Function and Muscle Growth
Beer, H. N., Lacey, T. A., Gibbs, R. L., Most, M. S., Hicks, Z. M., Grijalva, P. C. C., Marks-Nelson, E. S., Schmidt, T. B., Petersen, J. L., & Yates, D. T. (2024) · Metabolites · doi:10.3390/metabo14060340 · Cited by 5
What Is Frailty?
Ko, F., & Walston, J. D. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-3796-7.00063-x · Cited by 5
Respiratory and skeletal muscles in chronic obstructive pulmonary disease
Gayan‐Ramirez, G., Koulouris, N. G., Roca, J., & Decramer, M. (2006) · European Respiratory Society eBooks · doi:10.1183/1025448x.00038011 · Cited by 5
Impact of Patient Characteristics on the Outcomes of Patients with Gastrointestinal Cancers Treated with Immune Checkpoint Inhibitors
Ohm, H., & Abdel-Rahman, O. M. (2023) · Current Oncology · doi:10.3390/curroncol30010060 · Cited by 5
Facioscapulohumeral muscular dystrophy: Do neurotrophins play a role?
Angelucci, F., & Colantoni, L. (2009) · Muscle & Nerve · doi:10.1002/mus.21505 · Cited by 5
Exercise promotes IL‐6 release from legs in older men with minor response to unilateral immobilization
Reihmane, D., Gram, M., Vigelsø, A., Helge, J. W., & Dela, F. (2015) · European Journal of Sport Science · doi:10.1080/17461391.2015.1111939 · Cited by 5
Modulation of Wnt/β‐Catenin Signaling by STAT3 Inhibition Restores Myogenic Capacity in Sarcopenia
Zhang, S., Tao, X., Fu, M., Li, Y., Tu, G., Zhang, D., & Yin, L. (2025) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.70340 · Cited by 5
Can Myokines Serve as Supporters of Muscle–Brain Connectivity in Obesity and Type 2 Diabetes? Potential of Exercise and Nutrition Interventions
Lee, H., & Lim, Y. (2025) · Nutrients · doi:10.3390/nu17223615 · Cited by 5
Gut microbiota, sarcopenia, and type 2 diabetes: a triangular pathophysiological network
Jawed, F., Aziz, R., Mir, S. U. I., & Khan, S. A. (2026) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-026-01857-z · Cited by 4
How Inflamed Is the Horse in Training? Insights into Exercise-Induced Acute Phase Response in Endurance Horses
Rakowska, A., Biazik, A. K., Sobuś, M., & Cywińska, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052328 · Cited by 4
Influence of aspirin on aging skeletal muscle: Insights from a cross‐sectional cohort of septuagenarians
Fountain, W. A., Naruse, M., Finch, W. H., Claiborne, A., Trappe, S. W., & Trappe, T. A. (2023) · Physiological Reports · doi:10.14814/phy2.15669 · Cited by 4
Effectiveness and clinical application of multidisciplinary combined exercise and nutrition intervention for sarcopenic older adults with metabolic syndrome: study protocol for a multicentre randomised controlled trial
Lee, S. Y., Beom, J., Choi, J. H., Jang, H. C., Kim, E. Y., Kim, K., Kim, M., Shim, G. Y., Won, C. W., & Lim, J. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-070252 · Cited by 5
Intracellular and intercellular crosstalk between exosomes and autophagy
Li, Q., Chen, S., Yin, Y., Han, M., Shi, H., Gong, Y. L., Duan, X., Wang, Y., Guo, Q., Duan, Y., et al. (2025) · The Innovation Life · doi:10.59717/j.xinn-life.2025.100132 · Cited by 4
Intramuscular BoNT/A injections cause an inflammatory response in the muscle tissue of rats
Pingel, J., Pacolet, A., Elfving, B., & Ledri, L. N. (2021) · European Journal of Inflammation · doi:10.1177/20587392211039942 · Cited by 4
Novel intrathecal and subcutaneous catheter delivery systems in the mouse
Oladosu, F. A., Ciszek, B. P., O’Buckley, S. C., & Nackley, A. G. (2016) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2016.03.006 · Cited by 4
Cytokines and the Pathophysiology of Skeletal Muscle Atrophy
Baracos, V. E. (2005) · CRC Press eBooks · doi:10.1201/9780849333798.ch6 · Cited by 4
Effects of Alpha-hydroxy-isocaproic acid upon Body Composition in a Type I Diabetic Patient with Muscle Atrophy - A Case Study.
Teixeira, F. J., Matias, C. N., Monteiro, C. P., Howell, S. L., & KONES, R. J. (2018) · Europe PMC (PubMed Central) · Cited by 4
Early skeletal muscle loss and clinical outcomes in critically ill patients in the medical intensive care unit: A retrospective cohort study
Kim, S.-Y., Kang, D. H., Kim, D. K., Ahn, S. Y., Lee, M. R., & Lee, S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0338315 · Cited by 3
Dual Roles of Adipose Tissue in Skeletal Muscle Regeneration: Pro‐Regenerative Versus Maladaptive
Lu, C., Lu, F., & Cai, J. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70269 · Cited by 3
Dynamic model assuming mutually inhibitory biomarkers of frailty suggests bistability with contrasting mobility phenotypes
Schaumburger, N., Pally, J., Moraru, I. I., Kositsawat, J., Kuchel, G. A., & Blinov, M. L. (2023) · Frontiers in Network Physiology · doi:10.3389/fnetp.2023.1079070 · Cited by 3
Gingival bleeding as a predictor of handgrip strength—an observational study and a pilot randomized clinical trial
Roth, J. V. S., Guarenghi, G. G., Ferro, R. M., Valenga, H. M., Haas, A. N., Prates, R. C., & Steffens, J. P. (2024) · Clinical Oral Investigations · doi:10.1007/s00784-024-05507-7 · Cited by 3
Myokines Produced by Cultured Bovine Satellite Cells Harvested from 3- and 11-Month-Old Angus Steers
Shira, K. A., Murdoch, B. M., Thornton, K. J., Reichhardt, C. C., Becker, G. M., Chibisa, G. E., & Murdoch, G. K. (2024) · Animals · doi:10.3390/ani14050709 · Cited by 3
Association of tissue oxygen saturation levels with skeletal muscle injury in the critically ill
Sugiya, R., Arizono, S., Higashimoto, Y., Kimoto, Y., Shiraishi, M., Mizusawa, H., Tawara, Y., Shigeoka, H., Bakker, J., & Shinozaki, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-55118-1 · Cited by 3
Individual muscle hypertrophy response is affected by the overload progression model and is associated with changes in satellite cell content
Scarpelli, M. C., Bergamasco, J. G. A., Godwin, J. S., Mesquita, P. H. C., Chaves, T. S., da Silva, D. G., Bittencourt, D., Dias, N. F., Medalha, R. A., Filho, P. C. C., et al. (2025) · European Journal of Applied Physiology · doi:10.1007/s00421-025-05817-y · Cited by 4
Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells
Caputo, L., Stamenkovic, C., Tierney, M. T., Cecchini, A., Nicolau, M., Guarnaccia, G., Barajas, J. R., Falzarano, M. S., Bassel‐Duby, R., Ferlini, A., et al. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102692 · Cited by 3
Clinical outcomes of multidimensional association of type 2 diabetes mellitus, COVID-19 and sarcopenia: an algorithm and scoping systematic evaluation
Al‐Taie, A., Arueyingho, O., Khoshnaw, J., & Hafeez, A. (2022) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2022.2086265 · Cited by 3
The ameliorating effects of Tinospora species on the formation of advanced glycation end-products (AGEs) and associated oxidative stress
Singa, T. A., Okechukwu, P. N., Amit, Z., Ibrahim, M. J., Капитонова, М. Ю., & Froemming, G. R. A. (2022) · Medicinal Plants - International Journal of Phytomedicines and Related Industries · doi:10.5958/0975-6892.2022.00044.2 · Cited by 3
Bone marrow-derived dendritic cells play a role in attenuating inflammation on Bothrops jararacussu venom muscle damage.
Néry, N. M., Ferreira, A. F., Santana, H. M., Serrath, S. N., Reis, V., Paloschi, M. V., Silva, M. D. S., Magalhães, J. G. S., Cruz, L. F., Shibayama, T. Y., et al. (2024) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2024.11.014 · Cited by 3
New Strategies to Fight against Sarcopenia at Old Age
Meynial‐Denis, D., Guérin, O., Schneider, S. M., Volkert, D., & Sieber, C. C. (2012) · Journal of Aging Research · doi:10.1155/2012/676042 · Cited by 5
1,25-Dihydroxyvitamin D3 Inhibits Lipopolysaccharide-Induced Interleukin-6 Production by C2C12 Myotubes
Nonaka, K., Akiyama, J., Yoshikawa, Y., Une, S., & Ito, K. (2020) · Medicina · doi:10.3390/medicina56090450 · Cited by 3
Does inflammation markers or treatment type moderate exercise intensity effects on changes in muscle strength in cancer survivors participating in a 6-month combined resistance- and endurance exercise program? Results from the Phys-Can trial
Henriksson, A., Strandberg, E., Stenling, A., Mazzoni, A., Sjövall, K., Börjeson, S., Raastad, T., Demmelmaier, I., Berntsen, S., & Nordin, K. (2023) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-023-00617-3 · Cited by 3
Cytokines and the Pathophysiology of Skeletal Muscle Atrophy
Baracos, V. E. (2005) · CRC Press eBooks · doi:10.1201/9781420048957.ch6 · Cited by 3
Mechanisms of muscle atrophy in type 2 diabetes mellitus: factors dysregulating muscle protein synthesis and breakdown
Jeong, M., McColl, T. J., & Clarke, D. C. (2025) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2025-0017 · Cited by 4
Local injection of particles for retinoic acid drug delivery improves muscle structure and modulates inflammation in mice recovering from cast immobilization
Cheung, C. V., Searcy, R. A., Atube, K. J., Colonna, N. A., Krusen, K. E., Coppage, K. J., Holly, K. M., Pratz, R. P. W., Fournier, J. H., Sikirzhytski, V., et al. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00097.2025 · Cited by 2
Evaluation of the antidiabetic effects of green lipped mussel oil and its combination with low molecular weight fucoidan extracted from Undaria pinnatifida
Ebrahimi, B., Lessa, R. C., Lu, S., Baroutian, S., Suresh, V., Zhou, Q., Liu, J., & Lu, J. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117525 · Cited by 3
Muscle–immune metabolic crosstalk: shared pathways in cachexia and exercise
Westermann, S., Bennühr, B., Fumo, A. R., Rohm, M., & Hiller, K. (2026) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2026.103455 · Cited by 2
A randomized clinical trial of triamcinolone acetonide injection for suppression of inflammation after blepharoptosis surgery
Mimura, M., Matsuura, T., Takagi, M., Taki, K., Sato, Y., Fujita, Y., Oku, H., & Ikeda, T. (2021) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2021.11.084 · Cited by 2
The Relationship between Low-Grade Inflammation and Muscle Mass, Strength, and Physical Performance in a Geriatric Out-Patient Population
Rahbek, C., Kamper, R. S., Haddock, B., Andersen, H., Jørgensen, N., & Suetta, C. (2021) · Journal of Geriatric Medicine and Gerontology · doi:10.23937/2469-5858/1510119 · Cited by 2
The therapeutic potential of angiotensin-converting enzyme inhibitor enalapril to ameliorate muscle atrophy in a murine model
Seifi, S., Nazari, S. E., Avan, A., Khalili‐Tanha, N., Asgharzadeh, F., Babaei, F., Khalili‐Tanha, G., Asghari, S. Z., Darroudi, M., Ferns, G. A., et al. (2023) · EXCLI journal · doi:10.17179/excli2023-6822 · Cited by 2
Effect of Porphyromonas gingivalis Infection on Healing of Skeletal Muscle Injury: An In Vivo Study
Shimizu, S., Hayashi, K., Takeuchi, Y., Tanabe, G., Churei, H., Kobayashi, H., Ueno, T., & Fueki, K. (2024) · Dentistry Journal · doi:10.3390/dj12110346 · Cited by 2
Angiotensin II Type 1 Receptor Blocker Usage Prevents Oxidative Stress and Muscle Dysfunction in HIV
Deminice, R., Cella, P. S., Borsari, A. L., Padilha, C. S., & Oliveira, V. H. F. (2025) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.70016 · Cited by 2
Skeletal Muscle Homeostasis and Aging in Drosophila
Puppa, M., & Demontis, F. (2015) · Healthy ageing and longevity · doi:10.1007/978-3-319-18326-8_5 · Cited by 2
Functional Capacity and Inflammatory Mediators in Elderly Residents of Counties with Different Human Development Index
Lustosa, L. P., Xavier, D. R., Ribeiro-Samora, G. A., Pereira, D. S., Parentoni, A. N., Thomasini, R. L., & Pereira, L. S. M. (2020) · Journal of Aging Research · doi:10.1155/2020/9250929 · Cited by 2
Effects of Essential Amino Acid Supplementation on Muscular Adaptations to 3 Weeks of Combined Unilateral Glenohumeral & Radiohumeral Joints Immobilisation
Bostock, E. L. (2013) · Journal of Athletic Enhancement · doi:10.4172/2324-9080.1000116 · Cited by 2
G-CSF treatment can attenuate dexamethasone-induced reduction in C2C12 myotube protein synthesis
Wright, C. R., Brown, E. L., Ward, A. C., & Russell, A. P. (2015) · Cytokine · doi:10.1016/j.cyto.2015.01.012 · Cited by 2
Systemic inflammation and physical function in community elderly women
(2014) · Inflammation and Cell Signaling · doi:10.14800/ics.368 · Cited by 2
RISK FACTORS FOR DEVELOPING DIABETIC MYOPATHY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS
Chudova, N. I., & Pashkovа, O. Y. (2021) · World Science · doi:10.31435/rsglobal_ws/30052021/7587 · Cited by 2
Nutrigenomics, Inflammaging, and Osteoarthritis
Mobasheri, A., Barrett‐Jolley, R., Staunton, C. A., Ford, C., & Henrotin, Y. E. (2015) · Wiley eBooks · doi:10.1002/9781118930458.ch7 · Cited by 2
Low power infrared laser in pulsed emission mode modulates mRNA levels from pro-inflammatory and anti-inflammatory cytokines favoring repair process in injured muscle
Trajano, L. A. D. S. N., Trajano, E. T. L., Freire, T., Mencalha, A. L., Stumbo, A. C., & da Fonseca, A. D. S. (2018) · Laser Physics · doi:10.1088/1555-6611/aac29a · Cited by 1

Authors: Haddad, F., Zaldivar, F., Cooper, D. M., & Adams, G. R.
Affiliations: University of California, Irvine (US)
ORCID: Haddad, F.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2005-03
Volume: 98
Issue: 3
Pages: 911-917
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.01026.2004
OpenAlex: W2121311831
Cited by: 612
References: 60
Citations by year: 2026: 27 · 2025: 34 · 2024: 39 · 2023: 37 · 2022: 43 · 2021: 34 · 2020: 37 · 2019: 35 · 2018: 40 · 2017: 17 · 2016: 28 · 2015: 43 · 2014: 20 · 2013: 32 · 2012: 26
FWCI: 4.26
Type: journal article
Language: en
Open access: green
escholarship.org
Licence: cc-by
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders: National Institutes of Health (5r01ar045594-05)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-45594)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: interleukin-6, skeletal muscle atrophy, myofibrillar protein degradation, RSK, STAT5, STAT3, cytokine signaling, muscle atrophy, muscle catabolism, satellite cells, aging, physical activity
MeSH terms: Animals, Female, Muscle Proteins, Muscular Atrophy, Signal Transduction, Interleukin-6, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

IL-6-induced skeletal muscle atrophy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks