Modulation of glucose transport in skeletal muscle by reactive oxygen species
Abstract
Glucose transport is an essential physiological process that is characteristic of all eukaryotic cells, including skeletal muscle. In skeletal muscle, glucose transport is mediated by the GLUT-4 protein under conditions of increased carbohydrate utilization. The three major physiological stimuli of glucose transport in muscle are insulin, exercise/contraction, and hypoxia. Here, the role of reactive oxygen species (ROS) in modulating glucose transport in skeletal muscle is reviewed. Convincing evidence for ROS involvement in insulin- and hypoxia-mediated transport in muscle is lacking. Recent experiments, based on pharmacological and genetic approaches, support a role for ROS in contraction-mediated glucose transport. During contraction, endogenously produced ROS appear to mediate their effects on glucose transport via AMP-activated protein kinase.
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ROS show insulin-like effects, stimulating skeletal muscle glucose uptake during muscle contraction via the activation of AMPK and the induction of PGC-1α expression in vitro and in vivo.
“ROS show insulin-like effects, stimulating SkM glucose uptake during muscle contraction *via* the activation of AMPK ([81](#B81)) and the induction of PGC-1α expression *in vitro* and *in vivo* ([57](#B57), [79](#B79)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [81]
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References 81 · Cited by 65
- Authors
- Katz, A.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Katz, Abram
- ORCID
- Katz, Abram
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2007-04
- Volume
- 102
- Issue
- 4
- Pages
- 1671-1676
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2083357037
- Cited by
- 65
- References
- 81
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 4 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 6
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- glucose transport, skeletal muscle, reactive oxygen species, GLUT4, insulin signaling, hypoxia, muscle contraction, AMPK, physical activity
- MeSH terms
- Glucose, Homeostasis, Models, Biological, Muscle Contraction, Reactive Oxygen Species, Muscle, Skeletal, Glucose Transporter Type 4
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