The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
L-Type Calcium Channels: The Low Down
Abstract
L-type calcium channels couple membrane depolarization in neurons to numerous processes including gene expression, synaptic efficacy, and cell survival. To establish the contribution of L-type calcium channels to various signaling cascades, investigators have relied on their unique pharmacological sensitivity to dihydropyridines. The traditional view of dihydropyridine-sensitive L-type calcium channels is that they are high-voltage–activating and have slow activation kinetics. These properties limit the involvement of L-type calcium channels to neuronal functions triggered by strong and sustained depolarizations. This review highlights literature, both long-standing and recent, that points to significant functional diversity among L-type calcium channels expressed in neurons and other excitable cells. Past literature contains several reports of low-voltage–activated neuronal L-type calcium channels that parallel the unique properties of recently cloned Ca V 1.3 L-type channels. The fast kinetics and low activation thresholds of Ca V 1.3 channels stand in stark contrast to criteria currently used to describe L-type calcium channels. A more accurate view of neuronal L-type calcium channels encompasses a broad range of activation thresholds and recognizes their potential contribution to signaling cascades triggered by subthreshold depolarizations.
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Cites
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Binder, M. D., Powers, R. K., & Heckman, C. J. (2020) · Physiology · doi:10.1152/physiol.00026.2019 · Cited by 136
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Metadata
- Authors
- Lipscombe, D., Helton, T. D., & Xu, W.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2004-11
- Volume
- 92
- Issue
- 5
- Pages
- 2633-2641
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2163435696
- Cited by
- 425
- References
- 117
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- closed
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