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Staggered Development of GABAergic and Glycinergic Transmission in the MNTB
Abstract
Maturation of some brain stem and spinal inhibitory systems is characterized by a shift from GABAergic to glycinergic transmission. Little is known about how this transition is expressed in terms of individual axonal inputs and synaptic sites. We have explored this issue in the rat medial nucleus of the trapezoid body (MNTB). Synaptic responses at postnatal days 5-7 (P5-P7) were small, slow, and primarily mediated by GABA(A) receptors. By P8-P12, an additional, faster glycinergic component emerged. At these ages, GABA(A), glycine, or both types of receptors mediated transmission, even at single synaptic sites. Thereafter, glycinergic development greatly accelerated. By P25, evoked inhibitory postsynaptic currents (IPSCs) were 10 times briefer and 100 times larger than those measured in the youngest group, suggesting a proliferation of synaptic inputs activating fast-kinetic receptors. Glycinergic miniature IPSCs (mIPSCs) increased markedly in size and decay rate with age. GABAergic mIPSCs also accelerated, but declined slightly in amplitude. Overall, the efficacy of GABAergic inputs showed little maturation between P5 and P20. Although gramicidin perforated-patch recordings revealed that GABA or glycine depolarized P5-P7 cells but hyperpolarized P14-P15 cells, the young depolarizing inputs were not suprathreshold. In addition, vesicle-release properties of inhibitory axons also matured: GABAergic responses in immature rats were highly asynchronous, while in older rats, precise, phasic glycinergic IPSCs could transmit even with 500-Hz stimuli. Thus development of inhibition is characterized by coordinated modifications to transmitter systems, vesicle release kinetics, Cl- gradients, receptor properties, and numbers of synaptic inputs. The apparent switch in GABA/glycine transmission was predominantly due to enhanced glycinergic function.
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“By adulthood, both transmitters are inhibitory, activating their cognate chloride permeable ligand-gated ion channels, and hyperpolarizing their postsynaptic targets.48”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [48]
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Cites
Excitatory actions of gaba during development: the nature of the nurture
Ben-Ari, Y. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn920 · Cited by 2,448
Giant synaptic potentials in immature rat CA3 hippocampal neurones.
Ben‐Ari, Y., Cherubini, E., Corradetti, R., & Gaiarsa, J. L. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017762 · Cited by 1,317
Corelease of Two Fast Neurotransmitters at a Central Synapse
Jonas, P., Bischofberger, J., & Sandkühler, J. (1998) · Science · doi:10.1126/science.281.5375.419 · Cited by 784
Ganguly, K., Schinder, A. F., Wong, S. T., & Poo, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00341-5 · Cited by 719
Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain.
Malosio, M. L., Marquèze‐Pouey, B., Kuhse, J., & Betz, H. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07779.x · Cited by 557
Two components of transmitter release at a central synapse.
Goda, Y., & Stevens, C. F. (1994) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.91.26.12942 · Cited by 529
Taschenberger, H., & von Gersdorff, H. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09162.2000 · Cited by 486
Optimizing Synaptic Architecture and Efficiency for High-Frequency Transmission
Taschenberger, H., Leão, R. M., Rowland, K. C., Spirou, G. A., & von Gersdorff, H. (2002) · Neuron · doi:10.1016/s0896-6273(02)01137-6 · Cited by 389
Short-term plasticity at the calyx of held
von Gersdorff, H., & Borst, J. G. G. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn705 · Cited by 388
Glycine receptor heterogeneity in rat spinal cord during postnatal development.
Becker, C., Hoch, W., & Betz, H. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03255.x · Cited by 379
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Nakamura, P. A., & Cramer, K. S. (2013) · Neural Development · doi:10.1186/1749-8104-8-2 · Cited by 6
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Reyes‐Haro, D., Rosas‐Arellano, A., González‐González, M. A., Mora-Loyola, E., Miledi, R., & Martínez‐Torres, A. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.10.024 · Cited by 6
Kim, S. E., Lee, S. Y., Blanco, C. L., & Kim, J. H. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4734-13.2014 · Cited by 6
Alhadas, É. D. S. E., Correa, A. M., Naves, L. A., & Kushmerick, C. (2019) · Synapse · doi:10.1002/syn.22137 · Cited by 5
Regulation of Neurotransmitter Release by Presynaptic Receptors
Frerking, M. E., & Wondolowski, J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-481-0_14 · Cited by 5
Hruskova, B., Trojanova, J., Králíková, M., Melichar, A., Suchankova, S., Bartošová, J., Burianova, J. S., Popelář, J., Syka, J., & Tureček, R. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.01.058 · Cited by 5
Noguchi, T., Nakamura, S., Nakayama, K., Mochizuki, A., Dantsuji, M., Ihara, Y., Takahashi, K., & Inoue, T. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147753 · Cited by 3
Reyes‐Méndez, M. E., Osuna‐López, F., Herrera-Zamora, J. M., Navarro‐Polanco, R. A., Moreno-Galindo, E. G., & Alamilla, J. (2019) · Journal of Biological Rhythms · doi:10.1177/0748730419886990 · Cited by 3
The Use of Multiple Neurotransmitters at Synapses
Aldrich, S. B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815320-8.00021-1 · Cited by 3
Zhou, M., Yuan, J., Yan, Z., Dai, J., Wang, X., Xu, T., Xu, Q., Wang, N., & Liu, J. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.12.001 · Cited by 4
Therapeutic Potential of Nonpsychoactive Cannabinoids by Targeting at Glycine Receptors
Zhang, L. (2016) · InTech eBooks · doi:10.5772/63360 · Cited by 2
Developmental profile of microglia distribution in nuclei of the superior olivary complex
Zacher, A., Hohaus, K., Felmy, F., & Pätz, C. (2023) · The Journal of Comparative Neurology · doi:10.1002/cne.25547 · Cited by 4
GABA, Glycine, and Glutamate Co-Release at Developing Inhibitory Synapses
Gillespie, D. C., & Kandler, K. (2008) · Springer eBooks · doi:10.1007/978-0-387-09622-3_5 · Cited by 1
Amplitude modulation in the stellate microcircuit of the cochlear nucleus
Eager, M., Grayden, D. B., Hamish Meffin, A., & Burkitt, A. N. (2011) · International Conference on Intelligent Sensors, Sensor Networks and Information Processing · doi:10.1109/issnip.2011.6146619 · Cited by 1
Postsynaptic Determinants of Inhibitory Transmission at Mixed GABAergic/Glycinergic Synapses
Dieudonné, S., & Diana, M. A. (2008) · Springer eBooks · doi:10.1007/978-0-387-09622-3_7 · Cited by 1
Perinatal Development of the Medial Nucleus of the Trapezoid Body
Sivaramakrishnan, S., Brandebura, A. N., Holcomb, P. S., Heller, D., Kolson, D. R., Jackson, D., Mathers, P. H., & Spirou, G. A. (2018) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190849061.013.22 · Cited by 1
REFINEMENT OF INHIBITORY CIRCUITS DURING DEVELOPMENT OF THE MAMMALIAN AUDITORY BRAINSTEM
Kim, G. (2004) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1
Inhibitory Neurons in the Auditory Brainstem
Trussell, L. O. (2011) · Springer handbook of auditory research · doi:10.1007/978-1-4419-9517-9_7
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Gibbons, I., Sundaram, V., Adogwa, A., & Odekunle, A. (2020) · Brazilian Journal of Biology · doi:10.1590/1519-6984.230316
Benites, N. M., Rodrigues, B., da Silveira, C. H., & Leão, R. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.06.459172
Role of GABA /glycine depolarization and hyperpolarization in neonatal circuit development
Lee, H. (2007) · D-Scholarship@Pitt (University of Pittsburgh)
(2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_14
Benites, N. M. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2022.tde-03012023-123521
Simacek, C. A., Kirischuk, S., & Mittmann, T. (2025) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-025-03101-8
Heller, D. T., Benites, N. M., Amick, E. M., Dagostin, A., Young, S. M., von Gersdorff, H., & Spirou, G. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.28.672917
Dopamine–Glutamate and Dopamine–GABA Co-release
Scimemi, A. (2025) · Advances in neurobiology · doi:10.1007/978-3-031-96364-3_8
Lee, J., Brockway, B., & Kandler, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.01.691682
Lee, J., Brockway, B., & Kandler, K. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2520749123
Spécification fonctionnelle dans un système inhibiteur mixte GABA-glycine du cortex cérébelleux
Dumontier, D. (2019) · theses.fr (ABES) · doi:10.70675/e43294b6z4303z4c75z9888z74edae0778a6
Tanmy, T. T., Wang, H., & Lu, Y. (2026) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-026-01066-8
The developmental regulation of local and descending control of dorsal horn neurons in the rat
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Metadata
- Authors
- Awatramani, G. B., Turecek, R., & Trussell, L. O.
- Affiliations
- Oregon Health & Science University (US)
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2005-02
- Volume
- 93
- Issue
- 2
- Pages
- 819-828
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2025066952
- Cited by
- 138
- References
- 63
- Citations by year
- 2026: 2 · 2025: 5 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 10 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 14 · 2013: 11 · 2012: 3
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (DC04450, R01DC004450)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- medial nucleus of the trapezoid body, GABAergic neurotransmission, glycinergic transmission, inhibitory postsynaptic currents, miniature IPSCs, synapse maturation, GABAA receptor, glycine receptor, chloride gradient, postnatal development
- MeSH terms
- Age Factors, Animals, Brain Stem, gamma-Aminobutyric Acid, Glycine, Synaptic Transmission, Receptors, GABA-A, Rats, Wistar, Receptors, Glycine, Rats, GABA-A Receptor Agonists, In Vitro Techniques
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