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Cited by 80Neural dynamics and brain functionNeurobiology and Insect Physiology ResearchNeuroscience and Neuropharmacology Research

Phase maintenance in a rhythmic motor pattern during temperature changes in vivo

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Soofi, Wafa, Goeritz, Marie L., Kispersky, Tilman J., Prinz, Astrid A., Marder, Eve, Stein, Wolfgang·2014·Journal of Neurophysiology
DOI 10.1152/jn.00906.2013PMC PMC4044431
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Abstract

Central-pattern-generating neural circuits function reliably throughout an animal's life, despite constant molecular turnover and environmental perturbations. Fluctuations in temperature pose a problem to the nervous systems of poikilotherms because their body temperature follows the ambient temperature, thus affecting the temperature-dependent dynamics of various subcellular components that constitute neuronal circuits. In the crustacean stomatogastric nervous system, the pyloric circuit produces a triphasic rhythm comprising the output of the pyloric dilator, lateral pyloric, and pyloric constrictor neurons. In vitro, the phase relationships of these neurons are maintained over a fourfold change in pyloric frequency as temperature increases from 7°C to 23°C. To determine whether these temperature effects are also found in intact crabs, in the presence of sensory feedback and neuromodulator-rich environments, we measured the temperature dependence of the pyloric frequency and phases in vivo by implanting extracellular electrodes into Cancer borealis and Cancer pagurus and shifting tank water temperature from 11°C to 26°C. Pyloric frequency in the intact crab increased significantly with temperature (Q 10 = 2–2.5), while pyloric phases were generally conserved. For a subset of the C. borealis experiments, animals were subsequently dissected and the stomatogastric ganglion subjected to a similar temperature ramp in vitro. We found that the maximal frequency attained at high temperatures in vivo is lower than it is under in vitro conditions. Our results demonstrate that, over a wide temperature range, the phases of the pyloric rhythm in vivo are generally preserved, but that the frequency range is more restricted than it is in vitro.

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  • In initial studies of the effects of temperature on the pyloric rhythm of crabs, the rhythm increased in frequency in a permissive range, but then crashed or lost function at temperatures above 25-28°C.

    “In our initial studies of the effects of temperature on the pyloric rhythm of crabs, we found that the rhythm increased in frequency in a permissive range, but then 'crashed' or lost function at temperatures above 25-28 • C [41, 65,66].”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [65]

    The Results report that pyloric frequency increased as temperature rose from 11°C to 26°C and that motor patterns became more disrupted at higher temperatures. They do not establish that the rhythm generally crashed or lost function above 25–28°C: the experiments reached 26°C, and some animals retained regular bursts while others showed interruptions. The Discussion mentions LP-neuron failure approaching 27°C in prior in vitro work, not a general loss of the rhythm. (LLM, conf=0.87)

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Research works printed but not linked: 85

  1. Ausborn J, Stein W, Wolf H. Frequency control of motor patterning by negative sensory feedback. J Neurosci 27: 9319–9328, 2007 [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barrento S, Marques A, Vaz-Pires P, Nunes ML. Live shipment of immersed crabs Cancer pagurus from England to Portugal and recovery in stocking tanks: stress parameter characterization. ICES J Mar Sci 67: 435–443, 2010 [Google Scholar]
  3. Berkowitz A, Roberts A, Soffe SR. Roles for multifunctional and specialized spinal interneurons during motor pattern generation in tadpoles, zebrafish larvae, and turtles. Front Behav Neurosci 4: 36, 2010 [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bucher D, Prinz AA, Marder E. Animal-to-animal variability in motor pattern production in adults and during growth. J Neurosci 25: 1611–1619, 2005 [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Büschges A, Scholz H, El Manira A. New moves in motor control. Curr Biol 21: R513–R524, 2011 [DOI] [PubMed] [Google Scholar]
  6. Cao XJ, Oertel D. Temperature affects voltage-sensitive conductances differentially in octopus cells of the mammalian cochlear nucleus. J Neurophysiol 94: 821–832, 2005 [DOI] [PubMed] [Google Scholar]
  7. Caplan J, Williams AH, Marder E. Many parameter sets in a multicompartment model oscillator are robust to temperature perturbations. J Neurosci 34: 4963–4975, 2014 [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Chevallier S, Jan Ijspeert A, Ryczko D, Nagy F, Cabelguen JM. Organisation of the spinal central pattern generators for locomotion in the salamander: biology and modelling. Brain Res Rev 57: 147–161, 2008 [DOI] [PubMed] [Google Scholar]
  9. Cohen AH, Ermentrout GB, Kiemel T, Kopell N, Sigvardt KA, Williams TL. Modelling of intersegmental coordination in the lamprey central pattern generator for locomotion. Trends Neurosci 15: 434–438, 1992 [DOI] [PubMed] [Google Scholar]
  10. Daur N, Nadim F, Stein W. Regulation of motor patterns by the central spike-initiation zone of a sensory neuron. Eur J Neurosci 30: 808–822, 2009 [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Diehl F, White RS, Stein W, Nusbaum MP. Motor circuit-specific burst patterns drive different muscle and behavior patterns. J Neurosci 33: 12013–12029, 2013 [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Doherty JA. Temperature coupling and “trade-off” phenomena in the acoustic communication system of the cricket, Gryllus bimaculatus De Geer (Gryllidae). J Exp Biol 114: 17–35, 1985 [Google Scholar]
  13. Doi A, Ramirez JM. Neuromodulation and the orchestration of the respiratory rhythm. Respir Physiol Neurobiol 164: 96–104, 2008 [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Donahue MJ, Nichols A, Santamaria CA, League-Pike PE, Krediet CJ, Perez KO, Shulman MJ. Predation risk, prey abundance, and the vertical distribution of three brachyuran crabs on gulf of Maine shores. J Crustacean Biol 29: 523–531, 2009 [Google Scholar]
  15. Eisen JS, Marder E. A mechanism for production of phase shifts in a pattern generator. J Neurophysiol 51: 1375–1393, 1984 [DOI] [PubMed] [Google Scholar]
  16. El Manira A, Kyriakatos A, Nanou E. Beyond connectivity of locomotor circuitry-ionic and modulatory mechanisms. Prog Brain Res 187: 99–110, 2010 [DOI] [PubMed] [Google Scholar]
  17. Fee MS, Long MA. New methods for localizing and manipulating neuronal dynamics in behaving animals. Curr Opin Neurobiol 21: 693–700, 2011 [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Flamm RE, Harris-Warrick RM. Aminergic modulation in lobster stomatogastric ganglion. I. Effects on motor pattern and activity of neurons within the pyloric circuit. J Neurophysiol 55: 847–865, 1986 [DOI] [PubMed] [Google Scholar]
  19. Foster JA, Robertson RM. Temperature dependency of wing-beat frequency in intact and deafferented locusts. J Exp Biol 162: 295–312, 1992 [Google Scholar]
  20. Goodman L, Riley MA, Mitra S, Turvey MT. Advantages of rhythmic movements at resonance: minimal active degrees of freedom, minimal noise, and maximal predictability. J Mot Behav 32: 3–8, 2000 [DOI] [PubMed] [Google Scholar]
  21. Greenberg I, Manor Y. Synaptic depression in conjunction with A-current channels promote phase constancy in a rhythmic network. J Neurophysiol 93: 656–677, 2005 [DOI] [PubMed] [Google Scholar]
  22. Gutierrez GJ, Grashow RG. Cancer borealis stomatogastric nervous system dissection. J Vis Exp 25: 1207, 2009 [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Haddad SA, Marder E. Modulator induced changes in motor patterns are temperature compensated. Program No. 559.08. In: 2013 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2013 [Google Scholar]
  24. Haefner PA. Aspects of the biology of the jonah crab, Cancer borealis Stimpson, 1859 in the mid-Atlantic Bight. J Nat Hist 11: 303–320, 1977 [Google Scholar]
  25. Harris-Warrick RM. Neuromodulation and flexibility in central pattern generator networks. Curr Opin Neurobiol 21: 685–692, 2011 [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Harris-Warrick RM, Johnson BR, Peck JH, Kloppenburg P, Ayali A, Skarbinski J. Distributed effects of dopamine modulation in the crustacean pyloric network. Ann N Y Acad Sci 860: 155–167, 1998 [DOI] [PubMed] [Google Scholar]
  27. Hartline DK, Maynard DM. Motor patterns in the stomatogastric ganglion of the lobster Panulirus argus. J Exp Biol 62: 405–420, 1975 [DOI] [PubMed] [Google Scholar]
  28. Hedrich UB, Diehl F, Stein W. Gastric and pyloric motor pattern control by a modulatory projection neuron in the intact crab Cancer pagurus. J Neurophysiol 105: 1671–1680, 2011 [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Hedrich UBS, Stein W. Characterization of a descending pathway: activation and effects on motor patterns in the brachyuran crustacean stomatogastric nervous system. J Exp Biol 211: 2624–2637, 2008 [DOI] [PubMed] [Google Scholar]
  30. Heinzel HG, Weimann JM, Marder E. The behavioral repertoire of the gastric mill in the crab, Cancer pagurus: an in situ endoscopic and electrophysiological examination. J Neurosci 13: 1793–1803, 1993 [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Hooper SL. Phase maintenance in the pyloric pattern of the lobster (Panulirus interruptus) stomatogastric ganglion. J Comput Neurosci 4: 191–205, 1997a [DOI] [PubMed] [Google Scholar]
  32. Hooper SL. The pyloric pattern of the lobster (Panulirus interruptus) stomatogastric ganglion comprises two phase-maintaining subsets. J Comput Neurosci 4: 207–219, 1997b [DOI] [PubMed] [Google Scholar]
  33. Hooper SL. Transduction of temporal patterns by single neurons. Nat Neurosci 1: 720–726, 1998 [DOI] [PubMed] [Google Scholar]
  34. Hooper SL, O'Neil MB, Wagner R, Ewer J, Golowasch J, Marder E. The innervation of the pyloric region of the crab, Cancer borealis: homologous muscles in decapod species are differently innervated. J Comp Physiol A 159: 227–240, 1986 [DOI] [PubMed] [Google Scholar]
  35. Izumo M, Johnson CH, Yamazaki S. Circadian gene expression in mammalian fibroblasts revealed by real-time luminescence reporting: temperature compensation and damping. Proc Natl Acad Sci U S A 100: 16089–16094, 2003 [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Johnson BR, Peck JH, Harris-Warrick RM. Elevated temperature alters the ionic dependence of amine-induced pacemaker activity in a conditional burster neuron. J Comp Physiol A 170: 201–209, 1992 [DOI] [PubMed] [Google Scholar]
  37. Johnson BR, Peck JH, Harris-Warrick RM. Temperature sensitivity of graded synaptic transmission in the lobster stomatogastric ganglion. J Exp Biol 156: 267–285, 1991 [DOI] [PubMed] [Google Scholar]
  38. Jorge-Rivera JC, Marder E. TNRNFLRFamide and SDRNFLRFamide modulate muscles of the stomatogastric system of the crab Cancer borealis. J Comp Physiol A 179: 741–751, 1996 [DOI] [PubMed] [Google Scholar]
  39. Katz PS. Evolution and development of neural circuits in invertebrates. Curr Opin Neurobiol 17: 59–64, 2007 [DOI] [PubMed] [Google Scholar]
  40. Katz PS, Eigg MH, Harris-Warrick RM. Serotonergic/cholinergic muscle receptor cells in the crab stomatogastric nervous system. I. Identification and characterization of the gastropyloric receptor cells. J Neurophysiol 62: 558–570, 1989 [DOI] [PubMed] [Google Scholar]
  41. Katz PS, Harris-Warrick RM. Neuromodulation of the crab pyloric central pattern generator by serotonergic/cholinergic proprioceptive afferents. J Neurosci 10: 1495–1512, 1990 [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Kiehn O. Locomotor circuits in the mammalian spinal cord. Annu Rev Neurosci 29: 279–306, 2006 [DOI] [PubMed] [Google Scholar]
  43. Krediet CJ, Donahue MJ. Growth-mortality trade-offs along a depth gradient in Cancer borealis. J Exp Mar Bio Ecol 373: 133–139, 2009 [Google Scholar]
  44. Lenz PH, Hower AE, Hartline DK. Temperature compensation in the escape response of a marine copepod, Calanus finmarchicus (Crustacea). Biol Bull 209: 75–85, 2005 [DOI] [PubMed] [Google Scholar]
  45. Long MA, Fee MS. Using temperature to analyse temporal dynamics in the songbird motor pathway. Nature 456: 189–194, 2008 [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Manor Y, Bose A, Booth V, Nadim F. Contribution of synaptic depression to phase maintenance in a model rhythmic network. J Neurophysiol 90: 3513–3528, 2003 [DOI] [PubMed] [Google Scholar]
  47. Marder E, Bucher D. Understanding circuit dynamics using the stomatogastric nervous system of lobsters and crabs. Annu Rev Physiol 69: 291–316, 2007 [DOI] [PubMed] [Google Scholar]
  48. Marder E, Calabrese RL. Principles of rhythmic motor pattern generation. Physiol Rev 76: 687–717, 1996 [DOI] [PubMed] [Google Scholar]
  49. Marder E, Eisen JS. Electrically coupled pacemaker neurons respond differently to same physiological inputs and neurotransmitters. J Neurophysiol 51: 1362–1374, 1984 [DOI] [PubMed] [Google Scholar]
  50. Marder E, Weimann J. Modulatory control of multiple task processing in the stomatogastric nervous system. In: Neurobiology of Motor Programme Selection: New Approaches to the Study of Behavioural Choice, edited by Kien J, McCrohan C, Winlow W. New York: Pergamon, 1992 [Google Scholar]
  51. Maynard DM, Dando MR. The structure of the stomatogastric neuromuscular system in Callinectes sapidus, Homarus americanus and Panulirus argus (Decapoda Crustacea). Philos Trans R Soc Lond B Biol Sci 268: 161–220, 1974 [DOI] [PubMed] [Google Scholar]
  52. Maynard DM, Selverston AI. Organization of the stomatogastric ganglion of the spiny lobster IV: the pyloric system. J Comp Physiol 100: 161–182, 1975 [Google Scholar]
  53. Metzger R, Sartoris FJ, Langenbuch M, Portner HO. Influence of elevated CO(2) concentrations on thermal tolerance of the edible crab Cancer pagurus. J Therm Biol 32: 144–151, 2007 [Google Scholar]
  54. Meyrand P, Marder E. Matching neural and muscle oscillators: control by FMRFamide-like peptides. J Neurosci 11: 1150–1161, 1991 [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Moran MM, Xu H, Clapham DE. TRP ion channels in the nervous system. Curr Opin Neurobiol 14: 362–369, 2004 [DOI] [PubMed] [Google Scholar]
  56. Morris J, Maynard DM. Recordings from the stomatogastric nervous system in intact lobsters. Comparative Biochem and Physiol 33: 969–974, 1970 [Google Scholar]
  57. Morris LG, Hooper SL. Mechanisms underlying stabilization of temporally summated muscle contractions in the lobster (Panulirus) pyloric system. J Neurophysiol 85: 254–268, 2001 [DOI] [PubMed] [Google Scholar]
  58. Morris LG, Thuma JB, Hooper SL. Muscles express motor patterns of non-innervating neural networks by filtering broad-band input. Nat Neurosci 3: 245–250, 2000 [DOI] [PubMed] [Google Scholar]
  59. Myers BR, Sigal YM, Julius D. Evolution of thermal response properties in a cold-activated TRP channel. PLos One 4: e5741, 2009 [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Nadim F, Booth V, Bose A, Manor Y. Short-term synaptic dynamics promote phase maintenance in multi-phasic rhythms. Neurocomputing 52: 79–87, 2003 [Google Scholar]
  61. Nusbaum MP, Beenhakker MP. A small-systems approach to motor pattern generation. Nature 417: 343–350, 2002 [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Pearson KG, Wolf H. Comparison of motor patterns in the intact and deafferented flight system of the locust. J Comp Physiol A 160: 259–268, 1987 [Google Scholar]
  63. Preuss T, Faber DS. Central cellular mechanisms underlying temperature-dependent changes in the goldfish startle-escape behavior. J Neurosci 23: 5617–5626, 2003 [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Rathbun MJ. The cancroid crabs of America of the families Euryalidae, Portunidae, Atelecyclidao, Cancridao and Xanthidae. In: US National Museum Bulletin.Washington, DC: Smithsonian Institute, 1930, p. 193 [Google Scholar]
  65. Rezer E, Moulins M. Expression of the crustacean pyloric pattern generator in the intact animal. J Comp Physiol 153: 17–28, 1983 [Google Scholar]
  66. Rezer E, Moulins M. Humoral induction of pyloric rhythmic output in lobster stomatogastric ganglion: in vivo and in vitro studies. J Exp Biol 163: 209–230, 1992 [DOI] [PubMed] [Google Scholar]
  67. Rinberg A, Taylor AL, Marder E. The effects of temperature on the stability of a neuronal oscillator. PLoS Comput Biol 9: e1002857, 2013 [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Robertson RM, Money TGA. Temperature and neuronal circuit function: compensation, tuning and tolerance. Curr Opin Neurobiol 22: 724–734, 2012 [DOI] [PubMed] [Google Scholar]
  69. Robertson RM, Xu H, Shoemaker KL, Dawson-Scully K. Exposure to heat shock affects thermosensitivity of the locust flight system. J Neurobiol 29: 367–383, 1996 [DOI] [PubMed] [Google Scholar]
  70. Selverston AI, Miller JP. Mechanisms underlying pattern generation in lobster stomatogastric ganglion as determined by selective inactivation of identified neurons. I. Pyloric system. J Neurophysiol 44: 1102–1121, 1980 [DOI] [PubMed] [Google Scholar]
  71. Skinner FK, Mulloney B. Intersegmental coordination in invertebrates and vertebrates. Curr Opin Neurobiol 8: 725–732, 1998 [DOI] [PubMed] [Google Scholar]
  72. Smarandache CR, Daur N, Hedrich UBS, Stein W. Regulation of motor pattern frequency by reversals in proprioceptive feedback. Eur J Neurosci 28: 460–474, 2008 [DOI] [PubMed] [Google Scholar]
  73. Soofi W, Archila S, Prinz AA. Co-variation of ionic conductances supports phase maintenance in stomatogastric neurons. J Comput Neurosci 33: 77–95, 2012 [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Stehlik LL, Mackenzie CL, Morse WW. Distribution and abundance of four brachyuran crabs on the northwest Atlantic shelf. Fish Bull 89: 473–492, 1991 [Google Scholar]
  75. Stein W. Modulation of stomatogastric rhythms. J Comp Physiol A 195: 989–1009, 2009 [DOI] [PubMed] [Google Scholar]
  76. Tang LS, Goeritz ML, Caplan JS, Taylor AL, Fisek M, Marder E. Precise temperature compensation of phase in a rhythmic motor pattern. PLoS Biol 8: e1000469, 2010 [DOI] [PMC free article] [PubMed] [Google Scholar]
  77. Tang LS, Taylor AL, Rinberg A, Marder E. Robustness of a rhythmic circuit to short- and long-term temperature changes. J Neurosci 32: 10075–10085, 2012 [DOI] [PMC free article] [PubMed] [Google Scholar]
  78. Thompson SM, Masukawa LM, Prince DA. Temperature dependence of intrinsic membrane properties and synaptic potentials in hippocampal CA1 neurons in vitro. J Neurosci 5: 817–824, 1985 [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Thuma JB, Hobbs KH, Burstein HJ, Seiter NS, Hooper SL. Temperature sensitivity of the pyloric neuromuscular system and its modulation by dopamine. PLos One 8: e67930, 2013 [DOI] [PMC free article] [PubMed] [Google Scholar]
  80. Thuma JB, Morris LG, Weaver AL, Hooper SL. Lobster (Panulirus interruptus) pyloric muscles express the motor patterns of three neural networks, only one of which innervates the muscles. J Neurosci 23: 8911–8920, 2003 [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Weigeldt D, Böhm H, Heinzel HG. Sensory feedback in the operating stomatogastric nervous system of the crab ( Cancer pagurus). In: The Crustacean Nervous System, edited by Wiese K. Berlin: Springer-Verlag, 2002 [Google Scholar]
  82. Weimann JM, Marder E, Evans B, Calabrese RL. The effects of SDRNFLRFamide and TNRNFLRFamide on the motor patterns of the stomatogastric ganglion of the crab Cancer borealis. J Exp Biol 181: 1–26, 1993 [DOI] [PubMed] [Google Scholar]
  83. Whelan PJ, Pearson KG. Comparison of the effects of stimulating extensor group I afferents on cycle period during walking in conscious and decerebrate cats. Exp Brain Res 117: 444–452, 1997 [DOI] [PubMed] [Google Scholar]
  84. Yamaguchi A, Gooler D, Herrold A, Patel S, Pong WW. Temperature-dependent regulation of vocal pattern generator. J Neurophysiol 100: 3134–3143, 2008 [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. Zhurov Y, Brezina V. Temperature compensation of neuromuscular modulation in aplysia. J Neurophysiol 94: 3259–3277, 2005 [DOI] [PMC free article] [PubMed] [Google Scholar]

Cited by

Sorted by citations

Authors
Soofi, W., Goeritz, M. L., Kispersky, T. J., Prinz, A. A., Marder, E., & Stein, W.
Affiliations
  • Georgia Institute of Technology (US)
  • Brandeis University (US)
  • Emory University (US)
  • Universität Ulm (DE)
Corresponding author
Stein, Wolfgang
ORCID
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
2014-06-15
Volume
111
Issue
12
Pages
2603-2613
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.00906.2013
PMC
PMC4044431
OpenAlex
W1995818426
Cited by
80
References
0
Citations by year
2026: 8 · 2025: 2 · 2024: 18 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 5
FWCI
2.73
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS081013)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
pyloric rhythm, stomatogastric ganglion, pyloric circuit, temperature dependence, central pattern generator, Cancer borealis, Cancer pagurus, crustacean neuromodulation, in vivo and in vitro comparison, ectotherms, rhythmic motor patterns
MeSH terms
Animals, Biological Clocks, Brachyura, Electrodes, Implanted, Motor Activity, Species Specificity, Stomach, Temperature, Ganglia, Invertebrate, Tissue Culture Techniques

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