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Cited by 142Spinal Cord Injury ResearchStroke Rehabilitation and RecoveryNerve injury and regeneration

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Early Locomotor Training With Clonidine in Spinal Cats

Chau, Connie, Barbeau, Hugues, Rossignol, Serge·1998·Journal of Neurophysiology
DOI 10.1152/jn.1998.79.1.392
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Abstract

Clonidine, a noradrenergic alpha-2 agonist, can initiate locomotion early after spinalization in cats. Because this effect lasts 4-6 h, we have injected clonidine daily, intraperitoneally or intrathecally, and intensively trained five spinal cats to perform hindlimb walking on a treadmill starting at day 3 and continuing until 10 days posttransection. Each day, clonidine was injected to induce locomotor activity and cats were trained to walk with as much weight support as possible and at different speeds during multiple (1-5) locomotor training sessions, each lasting from 10 to 20 min, until the effects of clonidine wore off. Electromyographic (EMG) activity synchronized to video images of the hindlimbs were recorded before and after each clonidine injection. The results showed, first, a day-to-day change of the locomotor pattern induced by clonidine from the 3rd to the 11th day including an increase in the duration of the step cycle, an increase in the duration of extensor EMG activity, and an increase in total angular excursion of the hip, knee, and ankle joints. Second, after 6-11 days of this regimen, there was an emergence of a coordinated locomotor pattern with weight support of the hindquarters that was visible even before that day's clonidine injection. The results suggested that daily injection of clonidine followed by early and daily interactive locomotor training can enhance the recovery of locomotion in spinal cats.

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Crossref · 10.1152/jn.1998.79.1.392

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Research works printed but not linked: 6

  1. Barbeau H., 1992, Restorative Neurol. Neurosci., 12, 93
  2. Carrier L., 1992, Soc. Neurosci. Abstr., 18, 861
  3. Giroux N., 1995, Soc. Neurosci. Abstr., 21, 926
  4. Philippson M., 1905, Trav. Lab. Physiol. Inst. Solvay (Bruxelles), 7, 1
  5. Rossignol S., 1982, Soc. Neurosci. Abstr., 8, 163
  6. Wolpaw J. R., 1993, Adv. Neurol., 59, 163

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Metadata

Authors
Chau, C., Barbeau, H., & Rossignol, S.
Affiliations
  • Université de Montréal (CA)
  • McGill University (CA)
ORCID
Rossignol, Serge
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
1998-01-01
Volume
79
Issue
1
Pages
392-409
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.1998.79.1.392
OpenAlex
W2258205771
Cited by
142
References
42
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 5 · 2012: 6
FWCI
7.72
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
clonidine, spinal cord transection, treadmill training, alpha-2 adrenergic agonists, locomotion patterns, body weight support, electromyography
MeSH terms
Animals, Cats, Clonidine, Electromyography, Female, Laminectomy, Locomotion, Male, Motor Activity, Spinal Cord, Time Factors, Muscle, Skeletal

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