Calorie Restriction: Is AMPK a Key Sensor and Effector
Open accessAbstract
Dietary restriction can extend life span in most organisms tested to date, suggesting that mechanisms sensing nutrient and energy availability might regulate longevity. The AMP-activated protein kinase (AMPK) has emerged as a key energy sensor with the ability to transcriptionally reprogram the cell and metabolically adapt to external cues. In this review, we will discuss the possible role of AMPK in the beneficial effects of calorie restriction on health and life span.
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The cellular processes that mediate the benefits of calorie restriction on lifespan in mammalian species remain controversial, and there are caveats that limit a positive correlation in mammalian species versus more convincing evidence in lower eukaryotic organisms such as C. elegans.
“The cellular processes that mediate the benefits of calorie restriction on lifespan in mammalian species remain controversial and although it is tempting to assume an important role for AMPK as a key nutrient sensor, there are a number of caveats that limit a positive correlation in mammalian species versus more convincing evidence in lower eukaryotic organisms, such as C. elegans (219).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [219]
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References 123 · Cited by 282
- Authors
- Cantó, C., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Auwerx, Johan
- Venue
- Physiology
- Publisher
- American Physiological Society
- Published
- 2011-08
- Volume
- 26
- Issue
- 4
- Pages
- 214-224
- ISSN
- 0886-1714 (ISSN-L)
- 1548-9213
- 1548-9221
- PMC
- PMC3627048
- OpenAlex
- W2064405437
- Cited by
- 282
- References
- 123
- Citations by year
- 2026: 15 · 2025: 16 · 2024: 9 · 2023: 12 · 2022: 20 · 2021: 29 · 2020: 20 · 2019: 19 · 2018: 25 · 2017: 24 · 2016: 20 · 2015: 22 · 2014: 14 · 2013: 20 · 2012: 15
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-59820, P01DK059820)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- caloric restriction, AMPK, longevity, lifespan extension, energy sensing, nutrient sensing, metabolic adaptation, transcriptional reprogramming
- MeSH terms
- Animals, Humans, Longevity, Signal Transduction, Caloric Restriction, AMP-Activated Protein Kinases
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