Apoptotic Cell Death Under Hypoxia
Open accessAbstract
Eukaryotic life depends largely on molecular oxygen. During evolution, ingenious mechanisms have evolved that allow organisms to adapt when oxygen levels decrease. Many of these adaptional responses to low oxygen are orchestrated by the heterodimeric transcription factor hypoxia-inducible factor (HIF). Here, we review the link between HIF and apoptosis.
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When hypoxia is prolonged or adaptive capacity is exceeded, failure to restore oxygen homeostasis triggers programmed cell death pathways.
“When hypoxia is prolonged or adaptive capacity is exceeded, the failure to restore oxygen homeostasis triggers programmed cell death pathways”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [14]
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References 105 · Cited by 157
- Authors
- Sendoel, A., & Hengartner, M. O.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Hengartner, Michael O.
- ORCID
- Sendoel, Ataman
- Venue
- Physiology
- Publisher
- American Physiological Society
- Published
- 2014-05
- Volume
- 29
- Issue
- 3
- Pages
- 168-176
- ISSN
- 0886-1714 (ISSN-L)
- 1548-9213
- 1548-9221
- OpenAlex
- W2160448827
- Cited by
- 157
- References
- 105
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 21 · 2022: 19 · 2021: 36 · 2020: 18 · 2019: 14 · 2018: 5 · 2017: 12 · 2016: 7 · 2015: 7 · 2014: 3
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Physiology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- apoptosis, hypoxia, hypoxia-inducible factor, oxygen sensing, transcriptional regulation, low oxygen adaptation
- MeSH terms
- Adaptation, Physiological, Animals, Hypoxia, Humans, Oxygen, Cell Death, Apoptosis, Basic Helix-Loop-Helix Proteins
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