Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Van Remmen, Holly; Ikeno, Yuji; Hamilton, Michelle; Pahlavani, Mohammad; Wolf, Norman; Thorpe, Suzanne R.; Alderson, Nathan L.; Baynes, John W.; Epstein, Charles J.; Huang, Ting-Ting; Nelson, James; Strong, Randy; Richardson, Arlan

doi:10.1152/physiolgenomics.00122.2003

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Mice heterozygous for the Sod2 gene ( Sod2 +/− mice) have been used to study the phenotype of life-long reduced Mn-superoxide dismutase (MnSOD) activity. The Sod2 +/− mice have reduced MnSOD activity (∼50%) in all tissues throughout life. The Sod2 +/− mice have increased oxidative damage as demon…