The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach
Abstract
We have used methamphetamine treatment of rats as an animal model for psychotic mania. Specific brain regions were analyzed comprehensively for changes in gene expression using oligonucleotide GeneChip microarrays. The data was cross-matched against human genomic loci associated with either bipolar disorder or schizophrenia. Using this convergent approach, we have identified several novel candidate genes (e.g., signal transduction molecules, transcription factors, metabolic enzymes) that may be involved in the pathogenesis of mood disorders and psychosis. Furthermore, for one of these genes, G protein-coupled receptor kinase 3 (GRK3), we found by Western blot analysis evidence for decreased protein levels in a subset of patient lymphoblastoid cell lines that correlated with disease severity. Finally, the classification of these candidate genes into two prototypical categories, psychogenes and psychosis-suppressor genes, is described.
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Cites
Subgenual prefrontal cortex abnormalities in mood disorders
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Piecing together the Puzzle of Basal Forebrain Anatomy
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“These brain regions were chosen based on the extensive literature demonstrating their central role in cognition and emotion (24, 36).”
Localization of the Squalene Synthase Gene (FDFT1) to Human Chromosome 8p22-p23.1
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Cited by
Physiological Roles of G Protein–Coupled Receptor Kinases and Arrestins
Premont, R. T., & Gainetdinov, R. R. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.022405.154731 · Cited by 494
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Self-citationSuggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder
Nievergelt, C. M., Kripke, D. F., Barrett, T. B., Burg, E., Remick, R. A., Sadovnick, A. D., McElroy, S. L., Keck, P. E., Schork, N. J., & Kelsoe, J. R. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30252 · Cited by 294
Self-citationBiomarker Identification by Feature Wrappers
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Metadata
- Authors
- NICULESCU, A. B., SEGAL, D. S., KUCZENSKI, R., BARRETT, T., HAUGER, R. L., & KELSOE, J. R.
- Venue
- Physiological Genomics
- Publisher
- American Physiological Society
- Published
- 2000-11-09
- Volume
- 4
- Issue
- 1
- Pages
- 83-91
- ISSN
- 1094-8341 (ISSN-L)
- 1531-2267
- OpenAlex
- W1853587966
- Cited by
- 206
- References
- 5
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- NICULESCU, A. B., SEGAL, D. S., KUCZENSKI, R., BARRETT, T., HAUGER, R. L., & KELSOE, J. R. (2000). Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiological Genomics. https://doi.org/10.1152/physiolgenomics.2000.4.1.83
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
