Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity
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Obesity and type 2 diabetes mellitus (T2DM) often occur together and affect a growing number of individuals in both the developed and developing worlds. Both are associated with a number of other serious illnesses that lead to increased rates of mortality. There is likely a polygenic mode of inheritance underlying both disorders, but it has become increasingly clear that the pre- and postnatal environments play critical roles in pushing predisposed individuals over the edge into a disease state. This review focuses on the many genetic and environmental variables that interact to cause predisposed individuals to become obese and diabetic. The brain and its interactions with the external and internal environment are a major focus given the prominent role these interactions play in the regulation of energy and glucose homeostasis in health and disease.
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Perturbation of gene expression or cell proliferation and differentiation during vulnerable periods by nutritional and other environmental influences can alter the structure and functional capacity of major organ systems for life, a process known as developmental programming.
“Perturbation of gene expression or cell proliferation and differentiation during vulnerable periods by nutritional and other environmental influences can alter the structure and functional capacity of major organ systems for life, a process known as developmental programming.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [56]
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References 591 · Cited by 157
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- Authors
- Bouret, S., Levin, B. E., & Ozanne, S. E.
- Affiliations
- The Saban Research Institute, Neuroscience Program, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California; Inserm U837, Jean-Pierre Aubert Research Center, University Lille 2, Lille, France; Neurology Service, Veterans Administration Medical Center, East Orange, New Jersey; Department of Neurology and Neurosciences, Rutgers, New Jersey Medical School, Newark, New Jersey; and University of Cambridge Institute of Metabolic Science and MRC Metabolic Diseases Unit,...
- University of Southern California (US)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2015-01
- Volume
- 95
- Issue
- 1
- Pages
- 47-82
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- PMC
- PMC4281588
- OpenAlex
- W2334739015
- Cited by
- 157
- References
- 591
- Citations by year
- 2026: 1 · 2025: 12 · 2024: 14 · 2023: 11 · 2022: 16 · 2021: 8 · 2020: 8 · 2019: 16 · 2018: 12 · 2017: 19 · 2016: 23 · 2015: 16 · 2014: 1
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiological Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs (RD83544101)
- British Heart Foundation (FS/09/029/27902)
- U.S. Public Health Service (R01 53181, R01 30066 AND)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK84142, R01DK084142)
- National Institute of Environmental Health Sciences (P01ES022845)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- gene-environment interaction, obesity, type 2 diabetes, energy homeostasis, glucose homeostasis, intrauterine environment, postnatal environment, polygenic inheritance, disease susceptibility
- MeSH terms
- Animals, Diabetes Mellitus, Energy Metabolism, Environment, Glucose, Homeostasis, Humans, Neuronal Plasticity, Obesity, Genetic Predisposition to Disease, Gene-Environment Interaction
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