Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
Open accessAbstract
Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes involved in protecting cells from the damaging effects of ROS. ROS are produced in response to ultraviolet radiation, cigarette smoking, alcohol, nonsteroidal anti-inflammatory drugs, ischemia-reperfusion injury, chronic infections, and inflammatory disorders. Disruption of normal cellular homeostasis by redox signaling may result in cardiovascular, neurodegenerative diseases and cancer. ROS are produced within the gastrointestinal (GI) tract, but their roles in pathophysiology and disease pathogenesis have not been well studied. Despite the protective barrier provided by the mucosa, ingested materials and microbial pathogens can induce oxidative injury and GI inflammatory responses involving the epithelium and immune/inflammatory cells. The pathogenesis of various GI diseases including peptic ulcers, gastrointestinal cancers, and inflammatory bowel disease is in part due to oxidative stress. Unraveling the signaling events initiated at the cellular level by oxidative free radicals as well as the physiological responses to such stress is important to better understand disease pathogenesis and to develop new therapies to manage a variety of conditions for which current therapies are not always sufficient.
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Gastrointestinal problems involve Crohn's disease, reflux, esophagus cancer, and other disorders.
“GI problems involve Crohn’s disease, reflux, esophagus cancer, and other disorders (Bhattacharyya et al. 2014).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Bhattacharyya et al. 2014
Exogenous sources of ROS also involve consumption of smoked meat and intake of metal-containing drugs such as cyclosporine, bleomycin, and gentamycin.
“Exogenous sources of ROS also involve the consumption of smoked meat and intake of metal-containing drugs (cyclosporine, bleomycin, gentamycin, and others) (Bhattacharyya et al. 2014).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Bhattacharyya et al. 2014
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References 345 · Cited by 2,484
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- Authors
- Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E.
- Affiliations
- National Institute of Science Education and Research (IN)
- Corresponding author
- Crowe, Sheila E.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2014-04
- Volume
- 94
- Issue
- 2
- Pages
- 329-354
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- PMC
- PMC4044300
- OpenAlex
- W2155208388
- Cited by
- 2,484
- References
- 345
- Citations by year
- 2026: 186 · 2025: 290 · 2024: 342 · 2023: 308 · 2022: 266 · 2021: 259 · 2020: 195 · 2019: 152 · 2018: 198 · 2017: 164 · 2016: 87 · 2015: 28 · 2014: 9
- FWCI
- 9.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiological Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061769, R01 DK 61769)
- National Institute of Environmental Health Sciences (R01 ES 08457, R01ES008457)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- oxidative stress, reactive oxygen species, gastrointestinal mucosa, mucosal barrier, redox signaling, superoxide dismutase, glutathione peroxidase, catalase, peptic ulcer, gastrointestinal cancer, inflammatory bowel disease, oxidative damage, mucosal inflammation, pathogenesis
- MeSH terms
- Animals, Antioxidants, Gastric Mucosa, Gastrointestinal Diseases, Homeostasis, Humans, Intestinal Mucosa, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, Oxidative Stress
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